DK152210C - Analogifremgangsmaade til fremstilling af 2-allyl-6,7-dihydroxy-8-halogen-4-(p-hydroxyphenyl)-1,2,3,4-tetra-hydroisoquinoliner - Google Patents

Analogifremgangsmaade til fremstilling af 2-allyl-6,7-dihydroxy-8-halogen-4-(p-hydroxyphenyl)-1,2,3,4-tetra-hydroisoquinoliner

Info

Publication number
DK152210C
DK152210C DK300081A DK300081A DK152210C DK 152210 C DK152210 C DK 152210C DK 300081 A DK300081 A DK 300081A DK 300081 A DK300081 A DK 300081A DK 152210 C DK152210 C DK 152210C
Authority
DK
Denmark
Prior art keywords
hydroxyphenyl
allyl
hydroisoquinolines
dihydroxy
tetra
Prior art date
Application number
DK300081A
Other languages
Danish (da)
English (en)
Other versions
DK152210B (da
DK300081A (da
Inventor
L Martin Brenner
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of DK300081A publication Critical patent/DK300081A/da
Publication of DK152210B publication Critical patent/DK152210B/da
Application granted granted Critical
Publication of DK152210C publication Critical patent/DK152210C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK300081A 1980-07-08 1981-07-07 Analogifremgangsmaade til fremstilling af 2-allyl-6,7-dihydroxy-8-halogen-4-(p-hydroxyphenyl)-1,2,3,4-tetra-hydroisoquinoliner DK152210C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/166,933 US4340601A (en) 1980-07-08 1980-07-08 Dopaminergic isoquinolines
US16693380 1980-07-08

Publications (3)

Publication Number Publication Date
DK300081A DK300081A (da) 1982-01-09
DK152210B DK152210B (da) 1988-02-08
DK152210C true DK152210C (da) 1988-06-20

Family

ID=22605270

Family Applications (1)

Application Number Title Priority Date Filing Date
DK300081A DK152210C (da) 1980-07-08 1981-07-07 Analogifremgangsmaade til fremstilling af 2-allyl-6,7-dihydroxy-8-halogen-4-(p-hydroxyphenyl)-1,2,3,4-tetra-hydroisoquinoliner

Country Status (8)

Country Link
US (1) US4340601A (cs)
EP (1) EP0043729B1 (cs)
JP (1) JPS5762260A (cs)
AT (1) ATE6061T1 (cs)
DE (1) DE3162114D1 (cs)
DK (1) DK152210C (cs)
GR (1) GR74324B (cs)
IE (1) IE51371B1 (cs)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4876261A (en) * 1987-03-27 1989-10-24 Akihiro Tanaka Substituted tetrahydroisoquinoline compounds and composition containing them
US5204468A (en) * 1987-03-27 1993-04-20 Yamanouchi Pharmaceutical Co., Ltd. Substituted 4,5,6,7-tetrahydrothiens[2,3-C]pyridine compounds
EP1113007A1 (en) * 1999-12-24 2001-07-04 Pfizer Inc. Tetrahydroisoquinoline compounds as estrogen agonists/antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2813872A (en) * 1957-11-19 New sympatholytic allyl amine com-
US3947456A (en) * 1970-01-06 1976-03-30 Hoffman-La Roche Inc. Substituted 4-phenyl isoquinolines
US3666763A (en) * 1970-01-06 1972-05-30 Hoffmann La Roche 4-phenyl isoquinolines and process for preparing same
GB1386076A (en) * 1971-06-03 1975-03-05 Wyeth John & Brother Ltd Isoquinoline derivatives
US4042697A (en) * 1972-10-19 1977-08-16 Allen & Hanburys Limited Isoquinolium compounds for treating diabetes
US4197297A (en) * 1976-11-17 1980-04-08 Smithkline Corporation 6-Halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines
US4251525A (en) * 1979-05-25 1981-02-17 Smithkline Corporation 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives

Also Published As

Publication number Publication date
JPS5762260A (en) 1982-04-15
US4340601A (en) 1982-07-20
DK152210B (da) 1988-02-08
DE3162114D1 (de) 1984-03-08
IE51371B1 (en) 1986-12-10
DK300081A (da) 1982-01-09
ATE6061T1 (de) 1984-02-15
EP0043729B1 (en) 1984-02-01
EP0043729A1 (en) 1982-01-13
GR74324B (cs) 1984-06-22
IE811520L (en) 1982-01-08

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Legal Events

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PBP Patent lapsed