DK150512C - Analogifremgangsmaade til fremstilling af 3-quino-lincarboxylsyrederivater eller syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af 3-quino-lincarboxylsyrederivater eller syreadditionssalte deraf

Info

Publication number
DK150512C
DK150512C DK056077A DK56077A DK150512C DK 150512 C DK150512 C DK 150512C DK 056077 A DK056077 A DK 056077A DK 56077 A DK56077 A DK 56077A DK 150512 C DK150512 C DK 150512C
Authority
DK
Denmark
Prior art keywords
quino
analogue
preparation
addition salts
lincarboxylic
Prior art date
Application number
DK056077A
Other languages
Danish (da)
English (en)
Other versions
DK150512B (da
DK56077A (da
Inventor
Andre Allais
Francois Clemence
Roger Deraedt
Odile Le Martret
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of DK56077A publication Critical patent/DK56077A/da
Publication of DK150512B publication Critical patent/DK150512B/da
Application granted granted Critical
Publication of DK150512C publication Critical patent/DK150512C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
DK056077A 1976-02-11 1977-02-10 Analogifremgangsmaade til fremstilling af 3-quino-lincarboxylsyrederivater eller syreadditionssalte deraf DK150512C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7603754A FR2340735A1 (fr) 1976-02-11 1976-02-11 Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR7603754 1976-02-11

Publications (3)

Publication Number Publication Date
DK56077A DK56077A (da) 1977-08-12
DK150512B DK150512B (da) 1987-03-16
DK150512C true DK150512C (da) 1987-11-16

Family

ID=9168994

Family Applications (1)

Application Number Title Priority Date Filing Date
DK056077A DK150512C (da) 1976-02-11 1977-02-10 Analogifremgangsmaade til fremstilling af 3-quino-lincarboxylsyrederivater eller syreadditionssalte deraf

Country Status (19)

Country Link
US (1) US4107310A (US08063081-20111122-C00044.png)
JP (1) JPS52116479A (US08063081-20111122-C00044.png)
AU (1) AU508345B2 (US08063081-20111122-C00044.png)
BE (1) BE851306A (US08063081-20111122-C00044.png)
CA (1) CA1089464A (US08063081-20111122-C00044.png)
CH (1) CH620437A5 (US08063081-20111122-C00044.png)
DD (1) DD129552A5 (US08063081-20111122-C00044.png)
DE (1) DE2705446A1 (US08063081-20111122-C00044.png)
DK (1) DK150512C (US08063081-20111122-C00044.png)
ES (1) ES455804A1 (US08063081-20111122-C00044.png)
FR (1) FR2340735A1 (US08063081-20111122-C00044.png)
GB (1) GB1572482A (US08063081-20111122-C00044.png)
IE (1) IE44879B1 (US08063081-20111122-C00044.png)
IL (1) IL51413A (US08063081-20111122-C00044.png)
LU (1) LU76742A1 (US08063081-20111122-C00044.png)
NL (1) NL7701398A (US08063081-20111122-C00044.png)
SE (1) SE441528B (US08063081-20111122-C00044.png)
SU (1) SU867299A3 (US08063081-20111122-C00044.png)
ZA (1) ZA77787B (US08063081-20111122-C00044.png)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4190659A (en) * 1973-08-27 1980-02-26 Sandoz, Inc. Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters
US4187309A (en) * 1977-06-20 1980-02-05 Sandoz, Inc. 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
US4281131A (en) 1977-06-20 1981-07-28 Sandoz, Inc. 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
US4273930A (en) * 1977-06-20 1981-06-16 Sandoz, Inc. 4-Hydroxy-2-quinolinone-3-carboxylic acid esters
US4221797A (en) * 1978-08-14 1980-09-09 Sandoz, Inc. Dihydroquinoline-one derivatives
FR2443467A1 (fr) * 1978-12-08 1980-07-04 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2482596A1 (fr) * 1980-05-19 1981-11-20 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament
US4266050A (en) * 1980-07-02 1981-05-05 American Home Products Corporation 1,2-Dihydro-4-hydroxy-2-imino-N-substituted-3-quinolinecarboxamide derivatives
IE52670B1 (en) * 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
HU190796B (en) * 1981-06-12 1986-11-28 Roussel Uclaf,Fr Process for producing n-dihydrothiazolyl-3-quinoline-carboxamide derivatives
FR2507602A1 (fr) * 1981-06-12 1982-12-17 Roussel Uclaf Nouveau derive dihydrothiazole de la quinoleine, ses sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2523130A1 (fr) * 1982-03-15 1983-09-16 Roussel Uclaf Nouveaux derives de la n-dihydrothiazolyl-3-quinoleine carboxamide, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2509728A1 (fr) * 1981-07-17 1983-01-21 Roussel Uclaf Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2537139B2 (fr) * 1982-03-15 1985-09-20 Roussel Uclaf Nouveau derive de la n-dihydrothiazolyl 3-quinoleine carboxamide, procede de preparation, application a titre de medicament et compositions le renfermant
FR2530633A1 (fr) * 1982-06-03 1984-01-27 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, et les compositions les renfermant
FR2551437B2 (fr) * 1982-06-03 1985-10-25 Roussel Uclaf Nouveaux derives de l'acide 4-oh 3-quinoleine carboxylique substitues en 2, nouveau procede de preparation, leur application comme medicament et les compositions les renfermant et produits necessaires a leur preparation
FR2532939A1 (fr) * 1982-09-13 1984-03-16 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus
FR2537140B1 (fr) * 1982-12-07 1986-07-18 Roussel Uclaf Nouveaux derives de la 4-hydroxy-3-quinoleine carboxamide, leur sels, procede de preparation, application a titre de medicaments, et compositions les renfermant
SE452170B (sv) * 1983-10-03 1987-11-16 Boliden Ab Forfarande for utvinning av metall ur koppar och/eller edelmetall innehallande material som innehaller antimon och vismut
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
US4602014A (en) * 1984-07-09 1986-07-22 Ciba-Geigy Corporation Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodiazepine receptor modulators
JPH0358559A (ja) * 1989-07-26 1991-03-13 Sekisui Chem Co Ltd 電話システム
US5175151A (en) * 1990-09-07 1992-12-29 Schering Corporation Antiviral compounds and antihypertensive compounds
DE69128481T2 (de) * 1990-09-07 1998-04-09 Schering Corp Antivirale und antihypertensive verbindungen
US5179093A (en) * 1991-05-10 1993-01-12 Schering Corporation Quinoline-diones
DE4138820A1 (de) * 1991-11-26 1993-05-27 Basf Ag Chinolin-3-carbonsaeureamide, deren herstellung und verwendung
SE9201076L (sv) * 1992-04-06 1993-10-07 Shimon Slavin Användningen av gamla läkemedel för behandling av diabetes
SE9400810D0 (sv) * 1994-03-10 1994-03-10 Pharmacia Ab New use of Quinoline-3-carboxamide compounds
SE9400809D0 (sv) * 1994-03-10 1994-03-10 Pharmacia Ab New use of quinoline-3-carboxamide compounds
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
SE0400235D0 (sv) * 2004-02-06 2004-02-06 Active Biotech Ab New composition containing quinoline compounds
US8314124B2 (en) * 2004-02-06 2012-11-20 Active Biotech Ab Crystalline salts of quinoline compounds and methods for preparing them
RU2525115C2 (ru) * 2004-06-24 2014-08-10 Вертекс Фармасьютикалз Инкорпорейтед Способ модуляции транспортеров атф-связывающей кассеты
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
CN101006076B (zh) 2004-06-24 2010-09-29 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的调控剂
WO2006087830A1 (ja) * 2005-02-18 2006-08-24 Kanebo, Ltd. 帯状織物構造体およびその製法
NZ567088A (en) * 2005-10-19 2012-06-29 Teva Pharma Crystals of laquinimod sodium, and process for the manufacture thereof
JP2009521468A (ja) * 2005-12-24 2009-06-04 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｂｃ輸送体の調節因子としてのキノリン−４−オン誘導体
DK3219705T3 (da) 2005-12-28 2020-04-14 Vertex Pharma Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid
KR101495327B1 (ko) * 2006-06-12 2015-02-24 테바 파마슈티컬 인더스트리즈 리미티드 안정한 라퀴니모드 제제
US20080221161A1 (en) * 2007-02-09 2008-09-11 Kalypsys, Inc. Heterocyclic modulators of tgr5 for treatment of disease
WO2009082471A1 (en) * 2007-12-20 2009-07-02 Teva Pharmaceutical Industries, Ltd. Stable laquinimod preparations
WO2010028015A2 (en) * 2008-09-03 2010-03-11 Auspex Pharmaceuticals, Inc 2-oxo-1,2-dihydro-quinoline modulators of immune function
PT2408750E (pt) 2009-03-20 2015-10-15 Vertex Pharma Processo para a produção de modeladores do regulador de condutância transmembranar da fibrose cística
MX2012001333A (es) * 2009-07-30 2012-06-01 Teva Pharma Tratamiento de la enfermedad de crohn con la laquinimod.
EP3064206B1 (en) * 2009-08-10 2019-03-20 Active Biotech AB Treatment of huntington's disease using laquinimod
AU2011223697B2 (en) * 2010-03-03 2016-07-14 Teva Pharmaceutical Industries Ltd. Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate
NZ602512A (en) * 2010-03-03 2014-07-25 Teva Pharma Treatment of lupus arthritis using laquinimod
EA201290837A1 (ru) * 2010-03-03 2013-05-30 Тева Фармасьютикал Индастриз Лтд. Лечение волчаночного нефрита с применением лаквинимода
CN102267984B (zh) * 2010-06-04 2014-07-30 中国人民解放军军事医学科学院毒物药物研究所 4-羟基喹啉-3-酰胺衍生物及其制备方法和用途
BR112013007850A2 (pt) 2010-10-14 2016-06-07 Immunahr Ab 1,2-diidro-4-hidróxi-2-oxo-quinolina-3-carboxanilidas como ativadores de ahr
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
EP2537517A1 (en) * 2011-06-22 2012-12-26 Active Biotech AB Deuterium-enriched 4-hydroxy-5-methoxy-n,1-dimethyl-2-oxo-n-[(4-trifluoro-methyl)phenyl]-1,2-dihydroquinoline-3-carboxamide
BR112014008731A2 (pt) 2011-10-12 2017-04-25 Teva Pharma tratamento de esclerose múltipla com combinação de laquinimode e fingolimode
JP2015505564A (ja) 2012-02-03 2015-02-23 テバ ファーマシューティカル インダストリーズ リミティド 第一選択の抗ＴＮＥα療法に失敗したクローン病患者を治療するためのラキニモドの使用
EP2819670A1 (en) 2012-02-27 2015-01-07 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administration thereof
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
MX2015005632A (es) 2012-11-07 2016-02-05 Teva Pharma Sales de amina de laquinimod.
SG11201505952WA (en) 2013-01-31 2015-08-28 Vertex Pharma Quinoline and quinazoline amides as modulators of sodium channels
NZ630427A (en) 2013-03-14 2017-06-30 Teva Pharma Crystals of laquinimod sodium and improved process for the manufacture thereof
EP3137092A4 (en) 2014-04-29 2017-10-11 Teva Pharmaceutical Industries Ltd. Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status
RU2749213C2 (ru) 2014-10-07 2021-06-07 Вертекс Фармасьютикалз Инкорпорейтед Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL289475A (US08063081-20111122-C00044.png) * 1962-03-01
US3749731A (en) * 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
FR2281761A1 (fr) * 1974-08-13 1976-03-12 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament

Also Published As

Publication number Publication date
DE2705446C2 (US08063081-20111122-C00044.png) 1989-10-12
NL7701398A (nl) 1977-08-15
ES455804A1 (es) 1978-01-16
IE44879L (en) 1977-08-11
SE7700804L (sv) 1977-08-12
LU76742A1 (US08063081-20111122-C00044.png) 1977-08-19
US4107310A (en) 1978-08-15
JPS623152B2 (US08063081-20111122-C00044.png) 1987-01-23
CA1089464A (fr) 1980-11-11
GB1572482A (en) 1980-07-30
CH620437A5 (US08063081-20111122-C00044.png) 1980-11-28
DE2705446A1 (de) 1977-08-18
IE44879B1 (en) 1982-05-05
DK150512B (da) 1987-03-16
DD129552A5 (de) 1978-01-25
AU508345B2 (en) 1980-03-20
IL51413A0 (en) 1977-04-29
BE851306A (fr) 1977-08-10
FR2340735A1 (fr) 1977-09-09
SE441528B (sv) 1985-10-14
JPS52116479A (en) 1977-09-29
IL51413A (en) 1980-09-16
DK56077A (da) 1977-08-12
SU867299A3 (ru) 1981-09-23
AU2221877A (en) 1978-08-17
FR2340735B1 (US08063081-20111122-C00044.png) 1978-11-03
ZA77787B (en) 1978-03-29

Similar Documents

Publication Publication Date Title
DK150512C (da) Analogifremgangsmaade til fremstilling af 3-quino-lincarboxylsyrederivater eller syreadditionssalte deraf
DK144010C (da) Analogifremgangsmaade til fremstilling af 2-piperazinyl-6,7-dimethoxyquinazoliner eller syreadditionssalte deraf
DK149111C (da) Analogifremgangsmaade til fremstilling af histidinderivater eller syreadditionssalte deraf
DK143275C (da) Analogifremgangsmaade til fremstilling af 1-(3-dimethylaminopropyl)-phthalanderivater eller syreadditionssalte deraf
DK145119C (da) Analogifremgangsmaade til fremstilling af phenolethere eller syreadditionssalte deraf
DK147362C (da) Analogifremgangsmaade til fremstilling af ergolen- eller ergolin-derivater eller syreadditionssalte deraf
DK149594C (da) Analogifremgangsmaade til fremstilling af dipeptidderivater eller syreadditionssalte heraf
DK462380A (da) Analogifremgangsmaade til fremstilling af 2,4-diaminoquinazolin-forbindelser eller syreadditionssalte deraf
DK145260C (da) Analogifremgangsmaade til fremstilling af 4-acylamino-phenyl-ethanolaminer eller syreadditionssalte heraf
DK149609C (da) Analogifremgangsmaade til fremstilling af hydroxyamino-alkan- eller -alkenphosphonsyrederivater eller estere eller salte deraf
DK147858C (da) Analogifremgangsmaade til fremstilling af 5'-deoxy-5-fluorcytidin eller 5'-deoxy-5-fluoruridin eller fysiologisk tolerable syreadditionssalte dera
DK146592C (da) Analogifremgangsmaade til fremstilling af n-substituerede benzensulfonamider eller syreadditionssalte deraf
DK392877A (da) Fremgangsmaade til fremstilling af phenylethylaminer eller syreadditionssalte heraf
DK147942C (da) Analogifremgangsmaade til fremstilling af kanamycin a- eller kanamycin b-derivater eller syreadditionssalte deraf
DK144127C (da) Analogifremgangsmaade til fremstilling af lysergsyre- eller 9,10-dihydrolysergsyreamider eller syreadditionssalte deraf
DK146281C (da) Analogifremgangsmaade til fremstilling af 2-brom-6-fluor-n-2-imidazolidinyliden-benzamin eller syreadditionssalte heraf
DK159079A (da) Fremgangsmaade til fremstilling af derivater af 4-amino-2-piperidinoquinazolin eller syreadditionssalte deraf
DK140695B (da) Analogifremgangsmaade til fremstilling af 2,4-diamo-6,7-dimethoxyquinazolinderivater eller syreadditionssalte heraf
DK149077C (da) Analogifremgangsmaade til fremstilling af encephalin-analoge pentapeptidamidderivater eller farmaceutisk acceptable syreadditionssalte deraf
DK149841C (da) Analogifremgangsmaade til fremstilling af alfa-fluor-methyl-alfa-aminoalkansyrer eller farmaceutisk acceptable syreadditionssalte deraf
DK148281C (da) Analogifremgangsmaade til fremstilling af 8a-substituerede 8,8a-desoxy-8,8a-dihydrooleandomycin-forbindelser eller farmaceutiskacceptable syreadditionssalte deraf
DK144793C (da) Analogifremgangsmaade til fremstilling af dihydro- eller tetrahydroiminothiaziner eller farmaceutisk acceptable syreadditionssalte deraf
DK146886C (da) Analogifremgangsmaade til fremstilling af basisk substituerede o-propylerede oximer eller fysiologisk acceptable syreadditionssalte deraf
DK149628C (da) Analogifremgangsmaade til fremstilling af 8-substitueret-4ae-amino-makrolider eller syreadditionssalte deraf
DK151629C (da) Analogifremgangsmaade til fremstilling af 3-amino-1-benzoxepin-5(2h)-on-derivater eller syreadditionssalte deraf

Legal Events

Date Code Title Description
PBP Patent lapsed