DK1435239T3 - Stabiliseret og let forarbejdeligt granulat af amlodipin--maleat - Google Patents

Stabiliseret og let forarbejdeligt granulat af amlodipin--maleat

Info

Publication number
DK1435239T3
DK1435239T3 DK02293275T DK02293275T DK1435239T3 DK 1435239 T3 DK1435239 T3 DK 1435239T3 DK 02293275 T DK02293275 T DK 02293275T DK 02293275 T DK02293275 T DK 02293275T DK 1435239 T3 DK1435239 T3 DK 1435239T3
Authority
DK
Denmark
Prior art keywords
stabilized
amlodipine maleate
easily processable
granules
processable granules
Prior art date
Application number
DK02293275T
Other languages
Danish (da)
English (en)
Inventor
Pawan Seth
Original Assignee
Cimex Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cimex Pharma Ag filed Critical Cimex Pharma Ag
Application granted granted Critical
Publication of DK1435239T3 publication Critical patent/DK1435239T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK02293275T 2002-12-31 2002-12-31 Stabiliseret og let forarbejdeligt granulat af amlodipin--maleat DK1435239T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02293275A EP1435239B1 (de) 2002-12-31 2002-12-31 Stabilisiertes und verarbeitungsleichtes Granulat von Amlodipin Maleat

Publications (1)

Publication Number Publication Date
DK1435239T3 true DK1435239T3 (da) 2006-07-31

Family

ID=32479830

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02293275T DK1435239T3 (da) 2002-12-31 2002-12-31 Stabiliseret og let forarbejdeligt granulat af amlodipin--maleat

Country Status (7)

Country Link
EP (1) EP1435239B1 (de)
AT (1) ATE324891T1 (de)
CY (1) CY1105278T1 (de)
DE (1) DE60211192T2 (de)
DK (1) DK1435239T3 (de)
ES (1) ES2263754T3 (de)
PT (1) PT1435239E (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050019395A1 (en) * 2003-04-14 2005-01-27 Gabor Pragai Formulations of amlodipine maleate
KR100825039B1 (ko) * 2005-01-21 2008-04-24 대원제약주식회사 안정성이 개선된 암로디핀 말레이트염 정제
CA2785860A1 (en) * 2009-12-29 2011-07-28 Impax Laboratories, Inc. Gastroretentive solid oral dosage forms with swellable hydrophilic polymer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT5874U1 (de) * 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
GB0114709D0 (en) * 2001-06-15 2001-08-08 Pfizer Ltd Stabilised formulations of amlodipine maleate

Also Published As

Publication number Publication date
EP1435239A1 (de) 2004-07-07
EP1435239B1 (de) 2006-05-03
ES2263754T3 (es) 2006-12-16
CY1105278T1 (el) 2010-03-03
PT1435239E (pt) 2006-07-31
ATE324891T1 (de) 2006-06-15
DE60211192T2 (de) 2007-02-15
DE60211192D1 (de) 2006-06-08

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