DK141096B - Analogifremgangsmåde til fremstilling af substituerede xanthon-2-carboxylsyrer eller farmaceutisk acceptable, ikke-toxiske estere, amider eller salte deraf. - Google Patents
Analogifremgangsmåde til fremstilling af substituerede xanthon-2-carboxylsyrer eller farmaceutisk acceptable, ikke-toxiske estere, amider eller salte deraf. Download PDFInfo
- Publication number
- DK141096B DK141096B DK347772A DK347772A DK141096B DK 141096 B DK141096 B DK 141096B DK 347772 A DK347772 A DK 347772A DK 347772 A DK347772 A DK 347772A DK 141096 B DK141096 B DK 141096B
- Authority
- DK
- Denmark
- Prior art keywords
- carboxylic acid
- alkyl
- compound
- acid
- mixture
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims description 9
- 231100000252 nontoxic Toxicity 0.000 title claims description 5
- 230000003000 nontoxic effect Effects 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title description 16
- 238000000034 method Methods 0.000 title description 15
- 150000002148 esters Chemical class 0.000 title description 10
- 150000001408 amides Chemical class 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims description 51
- 239000002253 acid Substances 0.000 claims description 23
- -1 phenethyl-substituted amides Chemical class 0.000 claims description 19
- 238000011282 treatment Methods 0.000 claims description 13
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims description 7
- 241000700198 Cavia Species 0.000 claims description 6
- 229940047135 glycate Drugs 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 5
- SZGPJHJDNRNHIP-UHFFFAOYSA-N [Cr].[Na].[Na] Chemical compound [Cr].[Na].[Na] SZGPJHJDNRNHIP-UHFFFAOYSA-N 0.000 claims description 4
- 229960001340 histamine Drugs 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 150000002314 glycerols Chemical class 0.000 claims description 3
- 125000002252 acyl group Chemical group 0.000 claims description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 2
- 206010003591 Ataxia Diseases 0.000 claims 1
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- 239000000203 mixture Substances 0.000 description 43
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 42
- 238000006243 chemical reaction Methods 0.000 description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 29
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 24
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 23
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- 239000000243 solution Substances 0.000 description 17
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- 239000002585 base Substances 0.000 description 10
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- 239000000284 extract Substances 0.000 description 5
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- 241001465754 Metazoa Species 0.000 description 3
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- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
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- 239000000443 aerosol Substances 0.000 description 3
- 208000030961 allergic reaction Diseases 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 3
- 229910052794 bromium Inorganic materials 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 229960004592 isopropanol Drugs 0.000 description 3
- BWHLPLXXIDYSNW-UHFFFAOYSA-N ketorolac tromethamine Chemical compound OCC(N)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 BWHLPLXXIDYSNW-UHFFFAOYSA-N 0.000 description 3
- DWYSGMAREQOQEG-UHFFFAOYSA-N methyl 9h-xanthene-2-carboxylate Chemical compound C1=CC=C2CC3=CC(C(=O)OC)=CC=C3OC2=C1 DWYSGMAREQOQEG-UHFFFAOYSA-N 0.000 description 3
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- JNELGWHKGNBSMD-UHFFFAOYSA-N xanthone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3OC2=C1 JNELGWHKGNBSMD-UHFFFAOYSA-N 0.000 description 3
- AVQQQNCBBIEMEU-UHFFFAOYSA-N 1,1,3,3-tetramethylurea Chemical compound CN(C)C(=O)N(C)C AVQQQNCBBIEMEU-UHFFFAOYSA-N 0.000 description 2
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 2
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- 206010002198 Anaphylactic reaction Diseases 0.000 description 2
- VGCXGMAHQTYDJK-UHFFFAOYSA-N Chloroacetyl chloride Chemical compound ClCC(Cl)=O VGCXGMAHQTYDJK-UHFFFAOYSA-N 0.000 description 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
- C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
- C07D311/86—Oxygen atoms, e.g. xanthones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK373274A DK134699B (da) | 1971-07-14 | 1974-07-11 | Analogifremgangsmåde til fremstilling af xanthon-2-carboxylsyreforbindelser. |
| DK339376A DK339376A (da) | 1971-07-14 | 1976-07-28 | Analogifremgangsmade til fremstilling af substituerede xanthon-2-carboxylsyrer eller farmaceutisk acceptable, ikke-toxiske estere, amider eller salte deraf |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16269671A | 1971-07-14 | 1971-07-14 | |
| US16269671 | 1971-07-14 | ||
| US217383A US3873714A (en) | 1971-07-14 | 1972-01-12 | Xanthone carboxylic acids and derivatives |
| US21738372 | 1972-01-12 | ||
| US00259853A US3818042A (en) | 1972-01-12 | 1972-06-05 | Xanthone carboxylic acids and derivatives |
| US25985372 | 1972-06-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK141096B true DK141096B (da) | 1980-01-14 |
| DK141096C DK141096C (show.php) | 1980-07-14 |
Family
ID=27388786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK347772A DK141096B (da) | 1971-07-14 | 1972-07-12 | Analogifremgangsmåde til fremstilling af substituerede xanthon-2-carboxylsyrer eller farmaceutisk acceptable, ikke-toxiske estere, amider eller salte deraf. |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | AT326121B (show.php) |
| BE (1) | BE786169A (show.php) |
| CH (1) | CH580093A5 (show.php) |
| DE (1) | DE2234256A1 (show.php) |
| DK (1) | DK141096B (show.php) |
| ES (6) | ES404786A1 (show.php) |
| FR (1) | FR2145654B1 (show.php) |
| GB (1) | GB1386436A (show.php) |
| IL (1) | IL39890A (show.php) |
| NL (1) | NL7209628A (show.php) |
| SE (1) | SE388421B (show.php) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4242267A (en) | 1980-02-04 | 1980-12-30 | Roussel Uclaf | Process for preparing 5-alkyl-7-(S-alkyl-sulfonimidoyl)-xanthone-2-carboxylic acids |
| US4585876A (en) * | 1982-11-25 | 1986-04-29 | Ciba-Geigy Corporation | Novel xanthones and thioxanthones |
-
0
- BE BE786169D patent/BE786169A/xx unknown
-
1972
- 1972-07-12 AT AT599372A patent/AT326121B/de not_active IP Right Cessation
- 1972-07-12 DE DE19722234256 patent/DE2234256A1/de active Pending
- 1972-07-12 SE SE919672A patent/SE388421B/xx unknown
- 1972-07-12 NL NL7209628A patent/NL7209628A/xx unknown
- 1972-07-12 DK DK347772A patent/DK141096B/da unknown
- 1972-07-12 ES ES404786A patent/ES404786A1/es not_active Expired
- 1972-07-12 IL IL3989072A patent/IL39890A/en unknown
- 1972-07-12 FR FR7225353A patent/FR2145654B1/fr not_active Expired
- 1972-07-12 GB GB3253372A patent/GB1386436A/en not_active Expired
- 1972-07-12 CH CH1045672A patent/CH580093A5/xx not_active IP Right Cessation
-
1975
- 1975-03-15 ES ES435671A patent/ES435671A1/es not_active Expired
- 1975-03-15 ES ES435669A patent/ES435669A1/es not_active Expired
- 1975-03-15 ES ES435673A patent/ES435673A1/es not_active Expired
- 1975-03-15 ES ES435670A patent/ES435670A1/es not_active Expired
- 1975-03-15 ES ES435672A patent/ES435672A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES435671A1 (es) | 1977-05-01 |
| DE2234256A1 (de) | 1973-01-25 |
| AU4445672A (en) | 1974-01-17 |
| GB1386436A (en) | 1975-03-05 |
| CH580093A5 (show.php) | 1976-09-30 |
| AT326121B (de) | 1975-11-25 |
| ES404786A1 (es) | 1976-01-01 |
| ES435672A1 (es) | 1977-05-01 |
| NL7209628A (show.php) | 1973-01-16 |
| IL39890A (en) | 1976-02-29 |
| BE786169A (fr) | 1973-01-12 |
| ATA599372A (de) | 1975-02-15 |
| DK141096C (show.php) | 1980-07-14 |
| SE388421B (sv) | 1976-10-04 |
| ES435673A1 (es) | 1977-07-01 |
| FR2145654A1 (show.php) | 1973-02-23 |
| ES435669A1 (es) | 1977-05-01 |
| ES435670A1 (es) | 1977-05-01 |
| FR2145654B1 (show.php) | 1975-06-20 |
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