DK140594A - Prevention and treatment of sepsis and sepsis-related clotting disorders - Google Patents

Prevention and treatment of sepsis and sepsis-related clotting disorders

Info

Publication number
DK140594A
DK140594A DK140594A DK140594A DK140594A DK 140594 A DK140594 A DK 140594A DK 140594 A DK140594 A DK 140594A DK 140594 A DK140594 A DK 140594A DK 140594 A DK140594 A DK 140594A
Authority
DK
Denmark
Prior art keywords
sepsis
prevention
treatment
clotting disorders
related clotting
Prior art date
Application number
DK140594A
Other languages
Danish (da)
Inventor
George J Broze
Original Assignee
Searle & Co
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co, Monsanto Co filed Critical Searle & Co
Publication of DK140594A publication Critical patent/DK140594A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK140594A 1992-06-11 1994-12-08 Prevention and treatment of sepsis and sepsis-related clotting disorders DK140594A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89713592A 1992-06-11 1992-06-11
US2047293A 1993-02-22 1993-02-22
PCT/US1993/005409 WO1993025230A1 (en) 1992-06-11 1993-06-11 Prophylaxis and treatment of sepsis and sepsis-associated coagulation disorders

Publications (1)

Publication Number Publication Date
DK140594A true DK140594A (en) 1994-12-08

Family

ID=26693480

Family Applications (1)

Application Number Title Priority Date Filing Date
DK140594A DK140594A (en) 1992-06-11 1994-12-08 Prevention and treatment of sepsis and sepsis-related clotting disorders

Country Status (4)

Country Link
KR (1) KR950701820A (en)
AU (1) AU4408493A (en)
DK (1) DK140594A (en)
WO (1) WO1993025230A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212091A (en) * 1992-03-02 1993-05-18 Monsanto Company Method of producing tissue factor pathway inhibitor
US20030171292A1 (en) 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
CA2194443A1 (en) * 1994-07-07 1996-01-25 Dana R. Abendschein Method of attenuating arterial stenosis
US5824644A (en) * 1994-07-07 1998-10-20 G. D. Searle & Co. Method of attenuating arterial stenosis
US5589359A (en) * 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
US5914316A (en) * 1994-12-16 1999-06-22 Washington University Method of inhibiting intimal hyperplasia
US6242414B1 (en) 1995-06-07 2001-06-05 Chiron Corporation Regulation of cytokine synthesis and release
US5888968A (en) * 1995-06-07 1999-03-30 Chiron Corporation TFPI formulation
AU759412B2 (en) * 1995-06-07 2003-04-17 G.D. Searle & Co. Method of solubilizing, purifying and refolding protein and compositions comprising proteins and solubilizing agents
WO1996040784A2 (en) 1995-06-07 1996-12-19 Chiron Corporation Method of solubilizing, purifying, and refolding protein
AU2003200506B2 (en) * 1995-06-07 2007-01-18 G.D. Searle Llc Method of solubilizing, purifying and refolding protein and compositions comprising proteins and solubilizing agents
US5772629A (en) * 1995-10-23 1998-06-30 Localmed, Inc. Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels
JP2002533124A (en) 1998-12-31 2002-10-08 カイロン コーポレイション Improved expression of HIV polypeptide and generation of virus-like particles
US6939716B2 (en) 2001-09-19 2005-09-06 Washington University Method for detecting conditions indicative of sepsis
IL161408A0 (en) 2001-10-15 2004-09-27 Chiron Corp Treatment of sepsis by low dose administration of tissue factor pathway inhibitor (tfpi)
US7851433B2 (en) 2003-08-13 2010-12-14 Novartis Vaccines And Diagnostics, Inc. Method of purifying TFPI and TFPI analogs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK148890D0 (en) * 1990-06-19 1990-06-19 Novo Nordisk As PHARMACEUTICAL PREPARATION

Also Published As

Publication number Publication date
WO1993025230A1 (en) 1993-12-23
KR950701820A (en) 1995-05-17
AU4408493A (en) 1994-01-04

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment