DK1403278T3 - Synthesis procedure for N - [(S) -1-ethoxycarbonylbutyl] - (S) -alanine and its use in the synthesis of perindopril - Google Patents
Synthesis procedure for N - [(S) -1-ethoxycarbonylbutyl] - (S) -alanine and its use in the synthesis of perindoprilInfo
- Publication number
- DK1403278T3 DK1403278T3 DK03292404T DK03292404T DK1403278T3 DK 1403278 T3 DK1403278 T3 DK 1403278T3 DK 03292404 T DK03292404 T DK 03292404T DK 03292404 T DK03292404 T DK 03292404T DK 1403278 T3 DK1403278 T3 DK 1403278T3
- Authority
- DK
- Denmark
- Prior art keywords
- synthesis
- ethoxycarbonylbutyl
- perindopril
- alanine
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/06—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
- C07C251/08—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton being acyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03292404A EP1403278B1 (en) | 2003-09-30 | 2003-09-30 | Process for the synthesis of N-((S)-1-(ethoxycarbonyl)butyl)-(S)-alanine and use in the synthese of perindopril |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1403278T3 true DK1403278T3 (en) | 2005-10-03 |
Family
ID=31970535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03292404T DK1403278T3 (en) | 2003-09-30 | 2003-09-30 | Synthesis procedure for N - [(S) -1-ethoxycarbonylbutyl] - (S) -alanine and its use in the synthesis of perindopril |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1403278B1 (en) |
AR (1) | AR045849A1 (en) |
AT (1) | ATE297407T1 (en) |
DE (1) | DE60300806T2 (en) |
DK (1) | DK1403278T3 (en) |
ES (1) | ES2240926T3 (en) |
MY (1) | MY137391A (en) |
PT (1) | PT1403278E (en) |
SI (1) | SI1403278T1 (en) |
WO (1) | WO2005033127A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI21800A (en) | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | New procedure of synthesis of perindopril |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2807037B1 (en) * | 2000-03-31 | 2002-05-10 | Adir | NOVEL PROCESS FOR SYNTHESIS OF N - [(s) -1- CARBOXYBUTYL] - (S) -ALANINE ESTERS AND APPLICATION TO THE SYNTHESIS OF PERINDOPRIL |
FR2807430B1 (en) * | 2000-04-11 | 2002-05-17 | Adir | NOVEL PROCESS FOR THE SYNTHESIS OF N - [(S) -1- CARBOXYBUTYL] - (S) -ALANINE ESTERS AND APPLICATION TO THE SYNTHESIS OF PERINDOPRIL |
-
2003
- 2003-09-30 SI SI200330047T patent/SI1403278T1/en unknown
- 2003-09-30 AT AT03292404T patent/ATE297407T1/en active
- 2003-09-30 DE DE60300806T patent/DE60300806T2/en not_active Expired - Lifetime
- 2003-09-30 PT PT03292404T patent/PT1403278E/en unknown
- 2003-09-30 DK DK03292404T patent/DK1403278T3/en active
- 2003-09-30 ES ES03292404T patent/ES2240926T3/en not_active Expired - Lifetime
- 2003-09-30 EP EP03292404A patent/EP1403278B1/en not_active Expired - Lifetime
-
2004
- 2004-09-29 AR ARP040103525A patent/AR045849A1/en unknown
- 2004-09-29 MY MYPI20043999A patent/MY137391A/en unknown
- 2004-09-29 WO PCT/FR2004/002463 patent/WO2005033127A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP1403278B1 (en) | 2005-06-08 |
AR045849A1 (en) | 2005-11-16 |
PT1403278E (en) | 2005-09-30 |
DE60300806T2 (en) | 2006-03-23 |
DE60300806D1 (en) | 2005-07-14 |
EP1403278A1 (en) | 2004-03-31 |
ATE297407T1 (en) | 2005-06-15 |
ES2240926T3 (en) | 2005-10-16 |
SI1403278T1 (en) | 2005-10-31 |
MY137391A (en) | 2009-01-30 |
WO2005033127A1 (en) | 2005-04-14 |
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