DK1353929T3 - Streptogramin derivatives, their preparation and preparations containing the derivatives - Google Patents

Streptogramin derivatives, their preparation and preparations containing the derivatives

Info

Publication number
DK1353929T3
DK1353929T3 DK01995738T DK01995738T DK1353929T3 DK 1353929 T3 DK1353929 T3 DK 1353929T3 DK 01995738 T DK01995738 T DK 01995738T DK 01995738 T DK01995738 T DK 01995738T DK 1353929 T3 DK1353929 T3 DK 1353929T3
Authority
DK
Denmark
Prior art keywords
derivatives
streptogramin
preparation
preparations containing
bond
Prior art date
Application number
DK01995738T
Other languages
Danish (da)
Inventor
Eric Bacque
Jean-Claude Barriere
Pascal Desmazeau
Baptiste Ronan
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of DK1353929T3 publication Critical patent/DK1353929T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention concerns group A streptogramin derivatives of general formula (I) wherein: R1 represents cyano or ethynyl radicals; R2 represents a hydrogen atom or a methyl or ethyl radical; -the bond-- represents a single bond (stereochemistry 27R) or a double bond. Said derivatives are particularly interesting antibacterial agents.
DK01995738T 2000-12-21 2001-12-19 Streptogramin derivatives, their preparation and preparations containing the derivatives DK1353929T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0016804A FR2818645B1 (en) 2000-12-21 2000-12-21 STREPTOGRAMIN DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
PCT/FR2001/004060 WO2002050084A2 (en) 2000-12-21 2001-12-19 Streptogramin derivatives preparation thereof and compositions containing same
CA002431560A CA2431560A1 (en) 2000-12-21 2003-06-11 Derivatives of streptogramins, their preparation and compositions containing them

Publications (1)

Publication Number Publication Date
DK1353929T3 true DK1353929T3 (en) 2005-06-27

Family

ID=34227246

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01995738T DK1353929T3 (en) 2000-12-21 2001-12-19 Streptogramin derivatives, their preparation and preparations containing the derivatives

Country Status (10)

Country Link
EP (1) EP1353929B1 (en)
JP (2) JP4282323B2 (en)
AT (1) ATE291027T1 (en)
CA (1) CA2431560A1 (en)
DE (1) DE60109496T2 (en)
DK (1) DK1353929T3 (en)
ES (1) ES2240563T3 (en)
FR (1) FR2818645B1 (en)
PT (1) PT1353929E (en)
WO (1) WO2002050084A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2818645B1 (en) * 2000-12-21 2003-01-31 Aventis Pharma Sa STREPTOGRAMIN DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242938A (en) * 1992-08-27 1993-09-07 Merck & Co., Inc. Derivatives of virginiamycin M1
GB2301821B (en) * 1993-02-17 1997-07-09 Rhone Poulenc Rorer Sa Group A component of streptogramins
FR2766489B1 (en) * 1997-07-28 1999-08-27 Rhone Poulenc Rorer Sa STREPTOGRAMIN DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
FR2818645B1 (en) * 2000-12-21 2003-01-31 Aventis Pharma Sa STREPTOGRAMIN DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
ES2240563T3 (en) 2005-10-16
EP1353929A2 (en) 2003-10-22
EP1353929B1 (en) 2005-03-16
PT1353929E (en) 2005-07-29
JP2009149627A (en) 2009-07-09
FR2818645B1 (en) 2003-01-31
ATE291027T1 (en) 2005-04-15
WO2002050084A2 (en) 2002-06-27
FR2818645A1 (en) 2002-06-28
DE60109496T2 (en) 2006-03-02
JP2004520313A (en) 2004-07-08
CA2431560A1 (en) 2004-12-11
WO2002050084A3 (en) 2002-11-07
JP4282323B2 (en) 2009-06-17
DE60109496D1 (en) 2005-04-21

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