DK1240310T3 - Method of inactivating microorganisms - Google Patents

Method of inactivating microorganisms

Info

Publication number
DK1240310T3
DK1240310T3 DK00993526T DK00993526T DK1240310T3 DK 1240310 T3 DK1240310 T3 DK 1240310T3 DK 00993526 T DK00993526 T DK 00993526T DK 00993526 T DK00993526 T DK 00993526T DK 1240310 T3 DK1240310 T3 DK 1240310T3
Authority
DK
Denmark
Prior art keywords
microorganism
inactivant
cross
linking agent
inactivating microorganisms
Prior art date
Application number
DK00993526T
Other languages
Danish (da)
Inventor
Simon Johannes Barteling
Original Assignee
Agricultural Research Council
Inst Animal Science And Health
Simon Johannes Barteling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agricultural Research Council, Inst Animal Science And Health, Simon Johannes Barteling filed Critical Agricultural Research Council
Application granted granted Critical
Publication of DK1240310T3 publication Critical patent/DK1240310T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A61K39/135—Foot- and mouth-disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32161—Methods of inactivation or attenuation
    • C12N2770/32163—Methods of inactivation or attenuation by chemical treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Fertilizers (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

This invention provides methods of inactivating a microorganism and preparing a vaccine including the step of applying to said microorganism a cross-linking agent simultaneously with a separate inactivant. This invention further relates to vaccines prepared by such methods and a kit including such inactivated microorganism. The cross-linking agent is typically formaldehyde (FA) and the inactivant typically binary ethyleneimine (BEI).
DK00993526T 1999-12-20 2000-12-18 Method of inactivating microorganisms DK1240310T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA997757 1999-12-20
PCT/ZA2000/000254 WO2001046390A2 (en) 1999-12-20 2000-12-18 Method of inactivating microorganisms

Publications (1)

Publication Number Publication Date
DK1240310T3 true DK1240310T3 (en) 2008-05-26

Family

ID=25588046

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00993526T DK1240310T3 (en) 1999-12-20 2000-12-18 Method of inactivating microorganisms

Country Status (14)

Country Link
US (1) US6673349B2 (en)
EP (1) EP1240310B1 (en)
JP (1) JP2003517834A (en)
AT (1) ATE384786T1 (en)
AU (1) AU782907B2 (en)
BR (1) BR0016563A (en)
CA (1) CA2394946C (en)
CY (1) CY1107420T1 (en)
DE (1) DE60037907T2 (en)
DK (1) DK1240310T3 (en)
ES (1) ES2300286T3 (en)
PT (1) PT1240310E (en)
TR (1) TR200202104T2 (en)
WO (1) WO2001046390A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1734992T3 (en) * 2004-01-21 2011-12-05 Merial Ltd Enhanced inactivated FCV vaccines
AU2009327837A1 (en) * 2008-12-19 2011-07-28 Kabushiki Kaisha Saiwai Medical Method for preparing comprehensive anti-surface antibody using microorganism immobilized as antigen with protein crosslinking and immobilization reagent
WO2010144797A2 (en) 2009-06-12 2010-12-16 Vaccine Technologies, Incorporated Influenza vaccines with enhanced immunogenicity and uses thereof
CN102406931B (en) * 2011-11-25 2014-02-05 成都康华生物制品有限公司 Pandemic influenza virus split vaccine
CN105056225B (en) * 2015-07-30 2018-01-16 成都天邦生物制品有限公司 A kind of preparation method of inactivated vaccine
AU2017207076B2 (en) 2016-01-15 2021-04-29 Km Biologics Co., Ltd. Vaccine containing immobilized virus particles
CN114540317A (en) * 2022-03-17 2022-05-27 新疆方牧生物科技有限公司 Suspension culture process for inactivating orohoof virus

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1924303A1 (en) 1969-05-13 1970-12-17 Bayer Ag AEthylaethyleneimine as inactivating agent
US5069901A (en) * 1988-02-03 1991-12-03 Jones Elaine V Preparation of a recombinant subunit vaccine against pseudorabies infection
US5242686A (en) * 1990-11-07 1993-09-07 American Home Products Corporation Feline vaccine compositions and method for preventing chlamydia infections or diseases using the same
GB9110808D0 (en) * 1991-05-17 1991-07-10 Retroscreen Ltd Aids vaccine and method for its production
ES2152304T3 (en) * 1993-02-08 2001-02-01 Bayer Ag PROCEDURE FOR THE GROWTH OF VIRUS REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS AND ITS USE IN VACCINES.
KR19990077187A (en) * 1996-02-23 1999-10-25 데이비드 엠 모이어 Disinfection composition

Also Published As

Publication number Publication date
TR200202104T2 (en) 2002-12-23
PT1240310E (en) 2008-05-05
AU2979601A (en) 2001-07-03
BR0016563A (en) 2002-09-10
US6673349B2 (en) 2004-01-06
WO2001046390A3 (en) 2001-12-20
US20030035811A1 (en) 2003-02-20
DE60037907T2 (en) 2009-07-09
ATE384786T1 (en) 2008-02-15
CY1107420T1 (en) 2012-12-19
CA2394946C (en) 2010-12-14
ES2300286T3 (en) 2008-06-16
WO2001046390A2 (en) 2001-06-28
CA2394946A1 (en) 2001-06-28
AU782907B2 (en) 2005-09-08
DE60037907D1 (en) 2008-03-13
JP2003517834A (en) 2003-06-03
EP1240310B1 (en) 2008-01-23
EP1240310A2 (en) 2002-09-18

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