DK1156830T3 - Use of an oil-in-water emulsion for the manufacture of a drug - Google Patents

Use of an oil-in-water emulsion for the manufacture of a drug

Info

Publication number
DK1156830T3
DK1156830T3 DK00914043T DK00914043T DK1156830T3 DK 1156830 T3 DK1156830 T3 DK 1156830T3 DK 00914043 T DK00914043 T DK 00914043T DK 00914043 T DK00914043 T DK 00914043T DK 1156830 T3 DK1156830 T3 DK 1156830T3
Authority
DK
Denmark
Prior art keywords
disease
chronic
acute
water emulsion
oil
Prior art date
Application number
DK00914043T
Other languages
Danish (da)
Inventor
Heinrich Exner
Peter Klose
Original Assignee
Heinrich Exner
Peter Klose
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heinrich Exner, Peter Klose filed Critical Heinrich Exner
Application granted granted Critical
Publication of DK1156830T3 publication Critical patent/DK1156830T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an oil-in-water emulsion having the following composition: 0.01-30 % polydimethylsiloxane that has a degree of polymerisation of n = 20-400 and kinematic viscosity of 20-1,300 mm<2>/s, 0.01-15 % hydrophile emulgator, 45-99 % biocompatible saline solution and 0.01-10 % dimethylsulfoxide. The inventive oil-in-water emulsion can be used for producing a medicament against systemic inflammation, intensive care, virus diseases such as hepatitis C and aids, ulcerative colitis, Chron's disease, Parkinson's disease, Alzheimer's disease, multiple sclerosis, infectious hospitalism and/or infections of viral and/or bacterial genesis, bronchial asthma, infections of the kidneys and the urinary tract, migraine, rheumatoid arthritis, Sudeck's syndrome, acute and chronic inflammations, phlebitis, arteritis, acute and chronic states of exhaustion, tumours, muscular dystrophy and/or atrophy, haemorrhoids, chronic ischaemic heart disease, hypertonia, aging processes, acute and chronic pain, spasticities, polyneuropathies, prostate neoplasia, psilosis, impotence, neurodermitis, cervical syndrome, tissue traumatism or for the treatment thereof.
DK00914043T 1999-02-24 2000-02-23 Use of an oil-in-water emulsion for the manufacture of a drug DK1156830T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19910161 1999-02-24

Publications (1)

Publication Number Publication Date
DK1156830T3 true DK1156830T3 (en) 2006-05-29

Family

ID=7900130

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00914043T DK1156830T3 (en) 1999-02-24 2000-02-23 Use of an oil-in-water emulsion for the manufacture of a drug

Country Status (10)

Country Link
EP (1) EP1156830B1 (en)
JP (1) JP4383678B2 (en)
AT (1) ATE315408T1 (en)
AU (1) AU3550400A (en)
CA (1) CA2364606C (en)
DE (2) DE10080402D2 (en)
DK (1) DK1156830T3 (en)
ES (1) ES2255988T3 (en)
PT (1) PT1156830E (en)
WO (1) WO2000050085A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10113284A1 (en) * 2001-03-16 2002-10-02 Heinrich Exner Adjuvant emulsion and method of using it
DE10313196A1 (en) * 2003-03-19 2004-10-07 Exner, Heinrich, Dr.med.vet. Use of an emulsion comprising silicone, emulsifier, salt solution and dimethyl sulfoxide for treating or preventing diseases, e.g. resulting from the accumulation of harmful metabolites
JP2005075752A (en) * 2003-08-29 2005-03-24 Nippon Inst For Biological Science Vaccine preparation for porcine reproduction and respiratory syndrom
DE10353792A1 (en) * 2003-11-13 2005-06-23 Exner, Heinrich, Dr.med.vet. Ointment for treating or preventing inflammatory reactions comprises an ointment base and an emulsion comprising silicone, emulsifier, salt solution and dimethyl sulfoxide
DE102005009515A1 (en) 2005-02-25 2006-09-07 Exner, Heinrich, Dr. A process for preparing a preparation of a DMSO-containing solid silicone oil emulsion for binding reactive oxygen compounds in the body of humans and animals
DE102007007698A1 (en) * 2007-02-09 2008-08-21 Exner, Heinrich, Dr. Use of a highly emulsified silicone oil emulsion (HSE) for the manufacture of a medicament

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4499552C1 (en) * 1993-12-09 1997-07-17 Heinrich Dr Exner New incomplete and complete adjuvants for antigens
DE4445074A1 (en) * 1993-12-09 1995-06-29 Exner Heinrich Dr Med Vet Adjuvant for antigens, method of manufacture and use

Also Published As

Publication number Publication date
JP4383678B2 (en) 2009-12-16
JP2002537359A (en) 2002-11-05
WO2000050085A3 (en) 2000-12-28
EP1156830A2 (en) 2001-11-28
ATE315408T1 (en) 2006-02-15
CA2364606C (en) 2012-02-14
WO2000050085A2 (en) 2000-08-31
EP1156830B1 (en) 2006-01-11
PT1156830E (en) 2006-05-31
AU3550400A (en) 2000-09-14
CA2364606A1 (en) 2000-08-31
DE50012052D1 (en) 2006-04-06
DE10080402D2 (en) 2002-05-08
ES2255988T3 (en) 2006-07-16

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