DK1079856T3 - Humanized antibodies for recognition of verotoxin II as well as cell line for production of same - Google Patents
Humanized antibodies for recognition of verotoxin II as well as cell line for production of sameInfo
- Publication number
- DK1079856T3 DK1079856T3 DK99924395T DK99924395T DK1079856T3 DK 1079856 T3 DK1079856 T3 DK 1079856T3 DK 99924395 T DK99924395 T DK 99924395T DK 99924395 T DK99924395 T DK 99924395T DK 1079856 T3 DK1079856 T3 DK 1079856T3
- Authority
- DK
- Denmark
- Prior art keywords
- verotoxin
- humanized antibodies
- recognition
- production
- well
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The invention provides humanized antibodies that specifically bind to, and preferably, neutralize, verotoxin II (VT2). The antibodies are useful for treating patients suffering from, or at risk of suffering, toxic effects of verotoxin.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8657098P | 1998-05-20 | 1998-05-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1079856T3 true DK1079856T3 (en) | 2006-12-04 |
Family
ID=22199443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99924395T DK1079856T3 (en) | 1998-05-20 | 1999-05-19 | Humanized antibodies for recognition of verotoxin II as well as cell line for production of same |
Country Status (20)
Country | Link |
---|---|
US (1) | US7846435B1 (en) |
EP (1) | EP1079856B1 (en) |
JP (1) | JP4044733B2 (en) |
KR (1) | KR100548167B1 (en) |
CN (1) | CN1330375C (en) |
AT (1) | ATE335504T1 (en) |
AU (1) | AU748852B2 (en) |
BR (1) | BR9910589A (en) |
CA (1) | CA2328485C (en) |
DE (1) | DE69932719T2 (en) |
DK (1) | DK1079856T3 (en) |
ES (1) | ES2270598T3 (en) |
HK (1) | HK1036215A1 (en) |
IL (2) | IL139571A0 (en) |
NO (1) | NO326197B1 (en) |
NZ (1) | NZ508119A (en) |
PT (1) | PT1079856E (en) |
RU (1) | RU2217166C2 (en) |
WO (1) | WO1999059629A1 (en) |
ZA (1) | ZA200006370B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7910096B2 (en) | 1996-11-15 | 2011-03-22 | Trustees Of Tufts College | Human neutralizing antibodies against hemolytic uremic syndrome |
AU2007240614B2 (en) | 2006-04-20 | 2013-09-12 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine Incorporated | Methods and compositions based on Shiga toxin type 1 protein |
CA2748873C (en) | 2009-01-23 | 2017-09-12 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods and compositions based on shiga toxin type 2 protein |
JP6674603B2 (en) * | 2013-05-27 | 2020-04-01 | イムノヴァ エス.エー.Inmunova S.A. | Chimera of Brucella lumazine synthase and B subunit of AB5 toxin |
AU2015206002B2 (en) * | 2014-01-16 | 2020-06-11 | Mario Umberto Francesco MONDELLI | Neutralizing human monoclonal antibodies against Hepatitis B Virus surface antigen |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
JP3236667B2 (en) | 1991-06-28 | 2001-12-10 | 三菱化学株式会社 | Human monoclonal antibody and gene encoding the same, hybridoma and antitumor agent |
GB9125979D0 (en) | 1991-12-06 | 1992-02-05 | Wellcome Found | Antibody |
AU667533B2 (en) | 1992-03-26 | 1996-03-28 | Microcarb, Inc. | Monospecific polyclonal antibodies to shiga-like toxins |
CA2078716A1 (en) | 1992-09-21 | 1994-03-22 | Joyce De Azavedo | Attaching and effacing protein of enterohemorrhagic e. coli |
US5747272A (en) | 1994-02-14 | 1998-05-05 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Detection of shiga-like toxins of enterohemoragic Escherichia coli |
CA2116179C (en) | 1994-02-22 | 2008-01-08 | C. A. Lingwood | Verotoxin pharmaceutical compositions and medical treatments therewith |
EP0817647A4 (en) | 1995-03-24 | 2002-10-30 | Promega Corp | Treatment for verotoxin-producing escherichia coli |
CA2163716C (en) | 1995-11-24 | 2009-05-19 | Clifford A. Lingwood | Verotoxin pharmaceutical compositions and medical treatments therewith |
DE19641466A1 (en) | 1996-10-09 | 1998-04-16 | Biotest Pharma Gmbh | Oral use of an immunoglobulin preparation for the prevention of hemolytic uremic syndrome and a preparation therefor |
WO1998020903A1 (en) * | 1996-11-15 | 1998-05-22 | Trustees Of Tufts College | Humanized neutralizing antibodies against hemolytic uremic syndrome |
US20030170248A1 (en) * | 1997-12-23 | 2003-09-11 | Jeffrey R. Stinson | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
-
1999
- 1999-05-19 CA CA2328485A patent/CA2328485C/en not_active Expired - Fee Related
- 1999-05-19 DK DK99924395T patent/DK1079856T3/en active
- 1999-05-19 RU RU2000132226/14A patent/RU2217166C2/en not_active IP Right Cessation
- 1999-05-19 WO PCT/US1999/011179 patent/WO1999059629A1/en active IP Right Grant
- 1999-05-19 DE DE69932719T patent/DE69932719T2/en not_active Expired - Lifetime
- 1999-05-19 IL IL13957199A patent/IL139571A0/en unknown
- 1999-05-19 KR KR1020007012995A patent/KR100548167B1/en not_active IP Right Cessation
- 1999-05-19 ES ES99924395T patent/ES2270598T3/en not_active Expired - Lifetime
- 1999-05-19 AU AU40904/99A patent/AU748852B2/en not_active Ceased
- 1999-05-19 BR BR9910589-6A patent/BR9910589A/en not_active IP Right Cessation
- 1999-05-19 PT PT99924395T patent/PT1079856E/en unknown
- 1999-05-19 EP EP99924395A patent/EP1079856B1/en not_active Expired - Lifetime
- 1999-05-19 NZ NZ508119A patent/NZ508119A/en not_active IP Right Cessation
- 1999-05-19 CN CNB998063835A patent/CN1330375C/en not_active Expired - Fee Related
- 1999-05-19 JP JP2000549293A patent/JP4044733B2/en not_active Expired - Fee Related
- 1999-05-19 AT AT99924395T patent/ATE335504T1/en active
- 1999-05-19 US US09/700,851 patent/US7846435B1/en not_active Expired - Fee Related
-
2000
- 2000-11-07 ZA ZA200006370A patent/ZA200006370B/en unknown
- 2000-11-09 IL IL139571A patent/IL139571A/en not_active IP Right Cessation
- 2000-11-17 NO NO20005833A patent/NO326197B1/en not_active IP Right Cessation
-
2001
- 2001-09-07 HK HK01106324A patent/HK1036215A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP4044733B2 (en) | 2008-02-06 |
WO1999059629A1 (en) | 1999-11-25 |
CN1330375C (en) | 2007-08-08 |
JP2002515230A (en) | 2002-05-28 |
IL139571A0 (en) | 2002-02-10 |
NZ508119A (en) | 2003-06-30 |
US7846435B1 (en) | 2010-12-07 |
DE69932719T2 (en) | 2007-09-13 |
AU4090499A (en) | 1999-12-06 |
CN1301175A (en) | 2001-06-27 |
KR100548167B1 (en) | 2006-01-31 |
CA2328485C (en) | 2011-05-03 |
NO20005833D0 (en) | 2000-11-17 |
DE69932719D1 (en) | 2006-09-21 |
EP1079856B1 (en) | 2006-08-09 |
EP1079856A4 (en) | 2002-03-13 |
EP1079856A1 (en) | 2001-03-07 |
KR20010052367A (en) | 2001-06-25 |
ZA200006370B (en) | 2001-08-22 |
RU2217166C2 (en) | 2003-11-27 |
HK1036215A1 (en) | 2001-12-28 |
ES2270598T3 (en) | 2007-04-01 |
BR9910589A (en) | 2001-01-16 |
NO20005833L (en) | 2001-01-15 |
NO326197B1 (en) | 2008-10-13 |
PT1079856E (en) | 2006-12-29 |
ATE335504T1 (en) | 2006-09-15 |
CA2328485A1 (en) | 1999-11-25 |
AU748852B2 (en) | 2002-06-13 |
IL139571A (en) | 2009-09-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NZ594466A (en) | Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies | |
TR200103756T2 (en) | Treatment with humanized anti-ErbB2 antibodies and anti-ErbB2 antibodies. | |
RS80704A (en) | ANTI- av?6.ANTIBODIES | |
DE50106127D1 (en) | USE OF TRIFUNCTIONAL BISPEQIFIC AND TRISPECTIVE ANTIBODIES FOR THE TREATMENT OF MALIGNEM ASZITES | |
EP2363404A3 (en) | PSMA antibodies | |
ATE477273T1 (en) | HUMANIZED ANTIBODIES AGAINST GAMMA INTERFERON | |
TR200200472T2 (en) | Dosages for treatment with anti-Erb B2 antibodies | |
DK1951759T3 (en) | Anti-EGFR antibodies | |
EA201070695A1 (en) | MOLECULES OF HUMANIZED ANTIBODIES SPECIFIC TO IL-31 | |
MX2008007502A (en) | Anti-mn antibodies and methods of using same. | |
DE60135029D1 (en) | USE OF SOLUBLE CTLA4 MUTANTS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS | |
GEP20094829B (en) | Fully human antibodies against human 4-1bb (cd137) | |
ATE373719T1 (en) | HUMANIZED ANTIBODIES AGAINST CCR2 AND METHOD OF USE THEREOF | |
BRPI0506679A (en) | Methods of Treating Osteoarthritis with IL-6 Antagonists | |
RS53984B1 (en) | Ip-10 antibodies and their uses | |
DE69638269D1 (en) | HIGH-AFFINE HUMAN ANTIBODY AGAINST TUMORANTIGENE | |
MXPA05005925A (en) | Antibodies directed to phospholipase a2 and uses thereof. | |
EA200500232A1 (en) | METHODS OF DIAGNOSTICS AND TREATMENT OF PREECLAMPSIA OR ECLAMPSIA | |
PT1572087E (en) | Antibodies against cancer antigen tmeff2 and uses thereof | |
AU2002951409A0 (en) | Methods for regulating cancer | |
WO2002074251A3 (en) | Monoclonal antibody therapy for pancreas cancer | |
DK1079856T3 (en) | Humanized antibodies for recognition of verotoxin II as well as cell line for production of same | |
WO2004053102A3 (en) | Antibodies to treat cancer | |
WO2003072727A3 (en) | EGFRvIII SPECIFIC MONOCLONAL ANTIBODY AND EGFRvIII RIBOZYMES AND USE TO DETECT, TREAT OR PREVENT EGFRvIII ASSOCIATED CANCER | |
ATE296316T1 (en) | MONOCLONAL ANTIBODIES DIRECTED AGAINST HUMAN MCM3 PROTEIN, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE |