DK1035127T3 - Process for Preparation of N- [5- (Diphenylphosphinoylmethyl) -4- (4-fluorophenyl) -6-isopropylpyrimidin-2-yl] -N-methylmethanesulfonamide - Google Patents

Process for Preparation of N- [5- (Diphenylphosphinoylmethyl) -4- (4-fluorophenyl) -6-isopropylpyrimidin-2-yl] -N-methylmethanesulfonamide

Info

Publication number
DK1035127T3
DK1035127T3 DK00105011T DK00105011T DK1035127T3 DK 1035127 T3 DK1035127 T3 DK 1035127T3 DK 00105011 T DK00105011 T DK 00105011T DK 00105011 T DK00105011 T DK 00105011T DK 1035127 T3 DK1035127 T3 DK 1035127T3
Authority
DK
Denmark
Prior art keywords
fluorophenyl
diphenylphosphinoylmethyl
isopropylpyrimidin
methylmethanesulfonamide
preparation
Prior art date
Application number
DK00105011T
Other languages
Danish (da)
Inventor
Walter Dr Brieden
Ulrich Dr Veith
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Application granted granted Critical
Publication of DK1035127T3 publication Critical patent/DK1035127T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

N-(5-(diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6- isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide (I) is prepared by reaction of (4-(4- fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonyl-aminopyrimidin- 2-yl)methanol (II) with chlorodiphenylphosphine (III). Preparation of N-(5-(diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6- isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide of formula (I) comprises the reaction of (4-(4- fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonyl-aminopyrimidin- 2-yl)methanol of formula (II) with (III). Ph = phenyl; and Ph' = 4-fluorophenyl.
DK00105011T 1999-03-10 2000-03-09 Process for Preparation of N- [5- (Diphenylphosphinoylmethyl) -4- (4-fluorophenyl) -6-isopropylpyrimidin-2-yl] -N-methylmethanesulfonamide DK1035127T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99104786 1999-03-10
EP99104785 1999-03-10

Publications (1)

Publication Number Publication Date
DK1035127T3 true DK1035127T3 (en) 2003-11-03

Family

ID=26152921

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00105011T DK1035127T3 (en) 1999-03-10 2000-03-09 Process for Preparation of N- [5- (Diphenylphosphinoylmethyl) -4- (4-fluorophenyl) -6-isopropylpyrimidin-2-yl] -N-methylmethanesulfonamide

Country Status (16)

Country Link
EP (1) EP1035127B1 (en)
JP (1) JP4438167B2 (en)
KR (1) KR100586664B1 (en)
CN (1) CN1126755C (en)
AT (1) ATE251633T1 (en)
CA (1) CA2300243C (en)
CZ (1) CZ298235B6 (en)
DE (1) DE50003959D1 (en)
DK (1) DK1035127T3 (en)
ES (1) ES2208167T3 (en)
HK (1) HK1029996A1 (en)
HU (1) HU224967B1 (en)
NO (1) NO324982B1 (en)
PL (1) PL195166B1 (en)
PT (1) PT1035127E (en)
SK (1) SK284027B6 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0311195A (en) * 2002-05-21 2005-02-22 Ranbaxy Lab Ltd Rosuvastatin Preparation Process
US7341743B2 (en) 2004-10-28 2008-03-11 Revlon Consumer Products Corporation Color cosmetic compositions
WO2009143776A1 (en) 2008-05-27 2009-12-03 常州制药厂有限公司 Preparation method of rosuvastatin calcium and its intermediates

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2648897B2 (en) * 1991-07-01 1997-09-03 塩野義製薬株式会社 Pyrimidine derivatives

Also Published As

Publication number Publication date
CZ2000837A3 (en) 2000-10-11
CZ298235B6 (en) 2007-08-01
HUP0001127A3 (en) 2003-07-28
NO20001228D0 (en) 2000-03-09
JP4438167B2 (en) 2010-03-24
CA2300243A1 (en) 2000-09-10
PT1035127E (en) 2004-02-27
KR100586664B1 (en) 2006-06-07
NO20001228L (en) 2000-09-11
CA2300243C (en) 2009-12-29
HK1029996A1 (en) 2001-04-20
KR20010006773A (en) 2001-01-26
JP2000309595A (en) 2000-11-07
CN1126755C (en) 2003-11-05
DE50003959D1 (en) 2003-11-13
HU0001127D0 (en) 2000-05-28
SK284027B6 (en) 2004-08-03
EP1035127B1 (en) 2003-10-08
HUP0001127A2 (en) 2001-06-28
HU224967B1 (en) 2006-04-28
ES2208167T3 (en) 2004-06-16
EP1035127A1 (en) 2000-09-13
NO324982B1 (en) 2008-01-14
PL338944A1 (en) 2000-09-11
PL195166B1 (en) 2007-08-31
SK3322000A3 (en) 2000-10-09
ATE251633T1 (en) 2003-10-15
CN1272499A (en) 2000-11-08

Similar Documents

Publication Publication Date Title
ATE195938T1 (en) 2-(1',2',4'-TRIAZOLE-3'YLOXYMETHYLENE)-ANILIDES AND THEREOF USE AS PESTOPTIC AGENTS
PE20050018A1 (en) HETEROAROMATIC PENTACYCLIC COMPOUND AS INHIBITOR OF PROTEIN TYROSINE PHOSPHATASE 1B (PTB1B)
TR200401772T4 (en) substituted oxazole and thiazole derivatives as hPPAR alpha activators.
ATE211735T1 (en) 1-PHENYL-PYRAZOLE DERIVATIVES AND USE THEREOF AS PEST CONTROLS
TR200102957T2 (en) Method for the preparation of citalopram.
TR199901653T2 (en) Phthalazinones.
CO5271690A1 (en) PIRIMIDINE DERIVATIVES
ATE270278T1 (en) PHTHALAZINONE PDE III/IV INHIBITORS
ES8401031A1 (en) N-(3-substituted aminophenyl) tetrahydrophthalimides and herbicidal composition.
HUP0300649A2 (en) Fungicidal 5-phenyl substituted 2-(cyanoamino)pyrimidines, preparation and use thereof
NZ503912A (en) Piperidinylaminomethyl trifluoromethyl cyclic ether compounds and their use as substance P antagonists
AR026720A1 (en) URACILO COMPOUNDS AND APPLICATION OF THE SAME.
NO20022976L (en) 2- (1H-indol-3yl) -2-oxoacetamides with antitumor activity
EP1357124A4 (en) Heterocyclic compounds and cerebral function improvers containing the same as the active ingredient
DK1035127T3 (en) Process for Preparation of N- [5- (Diphenylphosphinoylmethyl) -4- (4-fluorophenyl) -6-isopropylpyrimidin-2-yl] -N-methylmethanesulfonamide
TR200302288T2 (en) New compounds and methods for therapy.
DK1377574T3 (en) 6-phenylbenzonaphthyridines
ATE266026T1 (en) BENZOFURANCARBOXAMIDES AND THEIR THERAPEUTIC USE
FI962768A (en) N- (2-phthalimidoethyl) substituted trans-piperidine-2,5-dicarboxylates
TR200103215T2 (en) 6 - [[(aryl and heteroaryl) oxy] methyl] naphthalene-2-carboxyimidamide derivatives, their preparation and therapeutic applications
HUP0204168A2 (en) Butyne diol derivatives, pharmaceutical composition containing the same and its preparation
ATE274508T1 (en) AMINOPHENOL DERIVATIVES
NO20020886L (en) Novel integrin <alfa> v <beta> 3 inhibitors
DE69836427D1 (en) Heterocyclic ketones as NPY Y5 antagonists
DE59814233D1 (en) Indolmethyl-N, N'-bisacylpiperazines as neurokinin receptor antagonists