DK1010694T3 - Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamine reuptake blockers - Google Patents

Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamine reuptake blockers

Info

Publication number
DK1010694T3
DK1010694T3 DK99403189T DK99403189T DK1010694T3 DK 1010694 T3 DK1010694 T3 DK 1010694T3 DK 99403189 T DK99403189 T DK 99403189T DK 99403189 T DK99403189 T DK 99403189T DK 1010694 T3 DK1010694 T3 DK 1010694T3
Authority
DK
Denmark
Prior art keywords
derivatives
spiroimidazoline
alpha2
monoamine reuptake
adrenergic antagonists
Prior art date
Application number
DK99403189T
Other languages
Danish (da)
Inventor
Alex Cordi
Mark Millan
Adrian Newman-Tancredi
Mauricette Brocco
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of DK1010694T3 publication Critical patent/DK1010694T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Spiro(imidazoline-anthracene) derivatives (I) are new. Spiro(imidazoline-anthracene) derivatives of formula (I) and their base or acid addition salts are new. R1-R4 = H, 1-6C alkyl, 1-6C alkoxy, OH, 1-6C polyhalogenoalkyl, cyano, nitro, amino, 1-6C alkylamino, di (1-6C) alkylamino, 1-6C thioalkyl, 1-6C sulfonylalkyl, 1-6C sulfinylalkyl, carboxy, 1-6C alkoxycarbonyl, 1-6C alkylcarbonyloxy, formyl, carbamoyl, carboxamide, phenyl, benzyl or halo; B' = a group of formula (i) or (ii); R = H, 1-6C alkyl or benzyl. Independent claims are also included for: (1) the preparation of (I); and (2) pharmaceutical compositions comprising at least one compound (I).
DK99403189T 1998-12-18 1999-12-17 Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamine reuptake blockers DK1010694T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9816000A FR2787450B1 (en) 1998-12-18 1998-12-18 NOVEL SPIROIMIDAZOLINIC DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number Publication Date
DK1010694T3 true DK1010694T3 (en) 2003-11-24

Family

ID=9534134

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99403189T DK1010694T3 (en) 1998-12-18 1999-12-17 Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamine reuptake blockers

Country Status (22)

Country Link
US (1) US6172097B1 (en)
EP (1) EP1010694B1 (en)
JP (1) JP3457241B2 (en)
KR (1) KR100472522B1 (en)
CN (1) CN1149201C (en)
AT (1) ATE246680T1 (en)
AU (1) AU760373B2 (en)
BR (1) BR9905904A (en)
CA (1) CA2292920C (en)
DE (1) DE69910156T2 (en)
DK (1) DK1010694T3 (en)
EA (1) EA002979B1 (en)
ES (1) ES2205741T3 (en)
FR (1) FR2787450B1 (en)
HK (1) HK1029117A1 (en)
HU (1) HU225820B1 (en)
NO (1) NO314402B1 (en)
NZ (1) NZ501890A (en)
PL (1) PL202368B1 (en)
PT (1) PT1010694E (en)
SI (1) SI1010694T1 (en)
ZA (1) ZA997735B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638981B2 (en) 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain
CA2716080C (en) 2008-02-20 2016-12-13 Targia Pharmaceuticals Cns pharmaceutical compositions and methods of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294185B1 (en) * 1993-03-12 2001-09-25 Auburn University Monomeric and polymeric cyclic amine and N-halamine compounds
FR2709306B1 (en) * 1993-07-20 1995-10-20 Adir New benzospiroalcene derivatives, process for their preparation and pharmaceutical compositions containing them.
FR2707981B1 (en) * 1993-07-20 1995-09-01 Adir New benzospiroalcene derivatives, process for their preparation and pharmaceutical compositions containing them.
FR2707982B1 (en) * 1993-07-20 1995-09-01 Adir New benzospiroalcene derivatives, process for their preparation and pharmaceutical compositions containing them.

Also Published As

Publication number Publication date
EA199901049A3 (en) 2000-08-28
BR9905904A (en) 2000-08-29
CA2292920A1 (en) 2000-06-18
PT1010694E (en) 2003-10-31
CA2292920C (en) 2004-01-27
DE69910156T2 (en) 2004-06-09
KR20000067830A (en) 2000-11-25
NO996285D0 (en) 1999-12-17
ES2205741T3 (en) 2004-05-01
US6172097B1 (en) 2001-01-09
EP1010694A3 (en) 2000-07-26
CN1264704A (en) 2000-08-30
HUP9904629A2 (en) 2000-08-28
AU6529199A (en) 2000-06-22
CN1149201C (en) 2004-05-12
JP2000178257A (en) 2000-06-27
EP1010694A2 (en) 2000-06-21
AU760373B2 (en) 2003-05-15
HK1029117A1 (en) 2001-03-23
EA199901049A2 (en) 2000-08-28
JP3457241B2 (en) 2003-10-14
NZ501890A (en) 2001-03-30
SI1010694T1 (en) 2003-12-31
FR2787450B1 (en) 2001-01-26
EP1010694B1 (en) 2003-08-06
ATE246680T1 (en) 2003-08-15
PL202368B1 (en) 2009-06-30
NO996285L (en) 2000-06-19
HU225820B1 (en) 2007-10-29
KR100472522B1 (en) 2005-03-07
DE69910156D1 (en) 2003-09-11
FR2787450A1 (en) 2000-06-23
EA002979B1 (en) 2002-12-26
NO314402B1 (en) 2003-03-17
PL337265A1 (en) 2000-06-19
HU9904629D0 (en) 2000-02-28
ZA997735B (en) 2000-06-19
HUP9904629A3 (en) 2000-12-28

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