DK0980379T3 - Chimeric oligonucleotides and their use - Google Patents

Chimeric oligonucleotides and their use

Info

Publication number
DK0980379T3
DK0980379T3 DK98933431T DK98933431T DK0980379T3 DK 0980379 T3 DK0980379 T3 DK 0980379T3 DK 98933431 T DK98933431 T DK 98933431T DK 98933431 T DK98933431 T DK 98933431T DK 0980379 T3 DK0980379 T3 DK 0980379T3
Authority
DK
Denmark
Prior art keywords
chimeric oligonucleotides
oligonucleotides
novel
relates
medicaments
Prior art date
Application number
DK98933431T
Other languages
Danish (da)
Inventor
Eckart Matthes
Janta-Lipinski Martin Von
Original Assignee
Max Delbrueck Centrum
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Delbrueck Centrum filed Critical Max Delbrueck Centrum
Application granted granted Critical
Publication of DK0980379T3 publication Critical patent/DK0980379T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention relates to novel oligonucleotides and their use, specially to inhibit the enzyme telomerase and to produce pharmaceutical formulations used in antitumoral therapy. The invention further relates to medicaments which contain the novel chimeric oligonucleotides.
DK98933431T 1997-05-02 1998-05-04 Chimeric oligonucleotides and their use DK0980379T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19720151A DE19720151A1 (en) 1997-05-02 1997-05-02 Chimeric oligonucleotides and their use
PCT/DE1998/001216 WO1998050397A2 (en) 1997-05-02 1998-05-04 Chimeric oligonucleotides and the use thereof

Publications (1)

Publication Number Publication Date
DK0980379T3 true DK0980379T3 (en) 2002-12-02

Family

ID=7829409

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98933431T DK0980379T3 (en) 1997-05-02 1998-05-04 Chimeric oligonucleotides and their use

Country Status (8)

Country Link
EP (1) EP0980379B1 (en)
JP (1) JP2001524972A (en)
AT (1) ATE221895T1 (en)
DE (2) DE19720151A1 (en)
DK (1) DK0980379T3 (en)
ES (1) ES2182340T3 (en)
PT (1) PT980379E (en)
WO (1) WO1998050397A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1992634A1 (en) * 1999-09-10 2008-11-19 Geron Corporation Oligonucleotide n3'- p5' thiophosphoramidates: their synthesis and use
US7563618B2 (en) * 2001-03-23 2009-07-21 Geron Corporation Oligonucleotide conjugates

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD279407A1 (en) * 1986-07-24 1990-06-06 Akad Wissenschaften Ddr METHOD FOR PRODUCING AN AGENT AGAINST AIDS
EP0355031A3 (en) * 1988-08-17 1990-12-27 MATTHES, Eckart, Dr. Substituted pyrimidine nucleosides, process for their preparation and pharmaceutical compounds containing them
US5489508A (en) * 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5643890A (en) * 1995-01-31 1997-07-01 The Board Of Regents Of The University Of Nebraska Synthetic oligonucleotides which mimic telomeric sequences for use in treatment of cancer and other diseases
US6015710A (en) * 1996-04-09 2000-01-18 The University Of Texas System Modulation of mammalian telomerase by peptide nucleic acids
AU2445997A (en) * 1996-04-10 1997-10-29 Lynx Therapeutics, Inc. Telomerase inhibitors
WO1998028442A1 (en) * 1996-12-20 1998-07-02 Geron Corporation Methods for detecting and inhibiting the rna component of telomerase

Also Published As

Publication number Publication date
ATE221895T1 (en) 2002-08-15
DE59805112D1 (en) 2002-09-12
DE19720151A1 (en) 1998-11-05
EP0980379B1 (en) 2002-08-07
JP2001524972A (en) 2001-12-04
EP0980379A2 (en) 2000-02-23
WO1998050397A2 (en) 1998-11-12
ES2182340T3 (en) 2003-03-01
PT980379E (en) 2002-12-31
WO1998050397A3 (en) 1999-02-11

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