DK0946566T3 - Prodrug forms and camptothecin analogues and their use as drugs - Google Patents

Prodrug forms and camptothecin analogues and their use as drugs

Info

Publication number
DK0946566T3
DK0946566T3 DK97950235T DK97950235T DK0946566T3 DK 0946566 T3 DK0946566 T3 DK 0946566T3 DK 97950235 T DK97950235 T DK 97950235T DK 97950235 T DK97950235 T DK 97950235T DK 0946566 T3 DK0946566 T3 DK 0946566T3
Authority
DK
Denmark
Prior art keywords
drugs
prodrug forms
camptothecin analogues
camptothecin
analogues
Prior art date
Application number
DK97950235T
Other languages
Danish (da)
Inventor
Dennis Bigg
Olivier Lavergne
Jerry Harnett
Alain Rolland
Anne-Marie Liberatore
Christophe Lanco
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9615775A external-priority patent/FR2757515B1/en
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Application granted granted Critical
Publication of DK0946566T3 publication Critical patent/DK0946566T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK97950235T 1996-12-20 1997-12-05 Prodrug forms and camptothecin analogues and their use as drugs DK0946566T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9615775A FR2757515B1 (en) 1996-12-20 1996-12-20 PRODROUGAL FORMS AND NEW CAMPTOTHECIN ANALOGS, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR9615945 1996-12-24
PCT/FR1997/002217 WO1998028304A1 (en) 1996-12-20 1997-12-05 Pro-drugs and counterparts of camptothecin, their application as medicines

Publications (1)

Publication Number Publication Date
DK0946566T3 true DK0946566T3 (en) 2004-03-15

Family

ID=26233188

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97950235T DK0946566T3 (en) 1996-12-20 1997-12-05 Prodrug forms and camptothecin analogues and their use as drugs

Country Status (24)

Country Link
EP (1) EP0946566B1 (en)
JP (1) JP3576174B2 (en)
KR (1) KR100516873B1 (en)
CN (1) CN1090634C (en)
AR (1) AR005849A1 (en)
AT (1) ATE253582T1 (en)
AU (1) AU734512B2 (en)
BR (1) BR9713977B1 (en)
CA (1) CA2275345C (en)
CZ (1) CZ299794B6 (en)
DE (1) DE69726007T2 (en)
DK (1) DK0946566T3 (en)
ES (1) ES2206760T3 (en)
HK (1) HK1024694A1 (en)
HU (1) HUP0001385A3 (en)
IL (2) IL129892A0 (en)
MY (1) MY122042A (en)
NO (1) NO324973B1 (en)
NZ (1) NZ335938A (en)
PL (1) PL188109B1 (en)
PT (1) PT946566E (en)
TW (1) TW410224B (en)
UA (1) UA57757C2 (en)
WO (1) WO1998028304A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790261B1 (en) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic NOVEL OPTICALLY PURE CAMPTOTHECIN ANALOGS AND PROCESSES FOR THEIR PREPARATION
EP1109789B1 (en) * 1998-09-02 2003-07-16 Pharmagenesis, Inc. Triptolide prodrugs having high aqueous solubility
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
FR2801309B1 (en) * 1999-11-18 2002-01-04 Adir NOVEL CAMPTOTHECIN-LIKE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US20040077674A1 (en) * 2002-03-01 2004-04-22 Curran Dennis P. Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
WO2003101998A1 (en) * 2002-06-03 2003-12-11 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
MXPA06006711A (en) * 2003-12-17 2006-08-31 Bionumerik Pharmaceuticals Inc Process for making camptothecin derivatives.
MXPA06011679A (en) * 2004-04-09 2007-01-23 Chugai Pharmaceutical Co Ltd Novel water-soluble prodrug.
ITRM20040288A1 (en) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti USE OF 7-T-BUTOXYIMINOMETHYL CAMPTOTECIN FOR THE PREPARATION OF A MEDICATION FOR THE TREATMENT OF UTERUS NEOPLASIES.
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
FR2892418B1 (en) * 2005-10-24 2010-10-22 Servier Lab NOVEL CAMPTOTHECIN-LIKE HYDROCARBON E-CYCLATE AMINOESTERIFIED COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2892417B1 (en) * 2005-10-24 2010-10-22 Servier Lab NOVEL AMINOESTERIFIED 7-CYPROCARBON HYDROCARBON COMPOUNDS COMPRISING CAMPTOTHECIN, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
CN100465175C (en) * 2005-11-29 2009-03-04 中国人民解放军第二军医大学 7-bit substituted comptothecine kind compound and pharmaceutical use thereof
CN100441580C (en) * 2006-07-14 2008-12-10 中山大学 Quinolyl dione derivative and its application in preparing antibiotic medicine
CN102746314B (en) * 2011-04-18 2016-07-06 华东师范大学 Containing stablizing the camptothecine compounds of 7 yuan of lactonic rings, preparation method and purposes
WO2023232145A1 (en) * 2022-06-02 2023-12-07 华东师范大学 Small molecule of homocamptothecins and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
RU2164515C2 (en) * 1995-06-21 2001-03-27 Сосьете де Консей де Решерш э Д'Аппликасьон Сьентифик (СКРАС) Campotecin compounds, methods of preparation thereof, intermediates, and therapeutic compositions

Also Published As

Publication number Publication date
AR005849A1 (en) 1999-07-21
PL188109B1 (en) 2004-12-31
IL129892A (en) 2007-09-20
ES2206760T3 (en) 2004-05-16
JP3576174B2 (en) 2004-10-13
MY122042A (en) 2006-03-31
CN1241192A (en) 2000-01-12
CZ209299A3 (en) 1999-09-15
HUP0001385A2 (en) 2000-10-28
CN1090634C (en) 2002-09-11
KR100516873B1 (en) 2005-09-26
CZ299794B6 (en) 2008-11-26
DE69726007T2 (en) 2004-06-03
BR9713977A (en) 2000-04-11
ATE253582T1 (en) 2003-11-15
PL334092A1 (en) 2000-01-31
AU734512B2 (en) 2001-06-14
BR9713977B1 (en) 2010-06-29
IL129892A0 (en) 2000-02-29
UA57757C2 (en) 2003-07-15
NO324973B1 (en) 2008-01-14
WO1998028304A1 (en) 1998-07-02
NO992997L (en) 1999-08-18
AU5326498A (en) 1998-07-17
NO992997D0 (en) 1999-06-18
EP0946566A1 (en) 1999-10-06
PT946566E (en) 2004-03-31
CA2275345C (en) 2010-01-26
HK1024694A1 (en) 2000-10-20
TW410224B (en) 2000-11-01
CA2275345A1 (en) 1998-07-02
JP2001506270A (en) 2001-05-15
HUP0001385A3 (en) 2002-12-28
DE69726007D1 (en) 2003-12-11
EP0946566B1 (en) 2003-11-05
KR20000062260A (en) 2000-10-25
NZ335938A (en) 2000-04-28

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