DK0945136T3 - Topical drug containing ciclosporin - Google Patents

Topical drug containing ciclosporin

Info

Publication number
DK0945136T3
DK0945136T3 DK99104009T DK99104009T DK0945136T3 DK 0945136 T3 DK0945136 T3 DK 0945136T3 DK 99104009 T DK99104009 T DK 99104009T DK 99104009 T DK99104009 T DK 99104009T DK 0945136 T3 DK0945136 T3 DK 0945136T3
Authority
DK
Denmark
Prior art keywords
pharmaceutical composition
composition containing
drug containing
topical drug
topical administration
Prior art date
Application number
DK99104009T
Other languages
Danish (da)
Inventor
Peter Edgar Dr Heide
Original Assignee
Peter Edgar Dr Heide
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peter Edgar Dr Heide filed Critical Peter Edgar Dr Heide
Application granted granted Critical
Publication of DK0945136T3 publication Critical patent/DK0945136T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Pharmaceutical composition containing cyclosporin A (I) is in the form of an oil-in-water nano emulsion. Independent claims are also included for the following: (1) use of a pharmaceutical composition containing (I) in a form suitable for topical administration for treating skin disorders; (2) use of a pharmaceutical composition containing (I) in a form suitable for topical administration for treating allergies; (3) preparation of the nano emulsion composition by dissolving (I) in an oil phase, adding part of the aqueous phase, stirring, adding the rest of the aqueous phase, sonicating the mixture, and sterilizing the product by filtration. ACTIVITY : Immunosuppressant. MECHANISM OF ACTION : Inhibitor of interleukin release.
DK99104009T 1998-03-12 1999-03-12 Topical drug containing ciclosporin DK0945136T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19810655A DE19810655A1 (en) 1998-03-12 1998-03-12 Pharmaceutical composition containing cyclosporin A suitable for topical administration for treating disorders of skin, mucosa and eyes

Publications (1)

Publication Number Publication Date
DK0945136T3 true DK0945136T3 (en) 2006-01-23

Family

ID=7860576

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99104009T DK0945136T3 (en) 1998-03-12 1999-03-12 Topical drug containing ciclosporin

Country Status (5)

Country Link
EP (1) EP0945136B9 (en)
AT (1) ATE309816T1 (en)
DE (2) DE19810655A1 (en)
DK (1) DK0945136T3 (en)
ES (1) ES2248935T3 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6623517B1 (en) * 1999-02-23 2003-09-23 Deluisa Laura Eye compress
US7354574B2 (en) 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
US7083802B2 (en) 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US7083803B2 (en) 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
US7087237B2 (en) 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
US7151085B2 (en) 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
US7135455B2 (en) 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
US8663639B2 (en) 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
CA2597590A1 (en) 2005-02-09 2006-08-17 Macusight, Inc. Formulations for ocular treatment
PL1904056T3 (en) 2005-07-18 2009-09-30 Minu Llc Use of a macrolide to restore corneal sensation
US8492400B2 (en) 2006-02-09 2013-07-23 Santen Pharmaceutical Co., Ltd. Stable formulations, and methods of their preparation and use
US7655625B2 (en) * 2006-02-13 2010-02-02 Allergan, Inc. Methods of treating blepharospasm using cyclosporine components
CN103127100A (en) 2006-03-23 2013-06-05 参天制药株式会社 Formulation and method for vascular permeability-related diseases or conditions
CN102271700A (en) * 2009-01-08 2011-12-07 阿勒根公司 Cyclosporine compositions for enhancing nail growth
DE102011108948A1 (en) 2011-07-29 2013-01-31 Achim Göpferich Aqueous, colloidal solutions of lipophilic substances, in particular drug solutions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61249918A (en) * 1985-04-26 1986-11-07 Yutaka Mizushima Eye drops
AU609242B2 (en) * 1988-01-29 1991-04-26 Novartis Ag Cyclosporin compositions
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
IL101007A (en) * 1992-02-18 1997-08-14 Pharmos Ltd Dry stable compositions prepared by lyophilization
DE4338086A1 (en) * 1993-11-08 1995-05-11 Dietl Hans Cyclosporin (e) containing pharmaceutical preparation for oral administration and process for their preparation
FI100692B (en) * 1994-05-24 1998-02-13 Leiras Oy A process for the preparation of pharmaceutical compositions, wherein the compositions are based on microemulsion gels and new gels directed to microemulsions.
ES2094688B1 (en) * 1994-08-08 1997-08-01 Cusi Lab MANOEMULSION OF THE TYPE OF OIL IN WATER, USEFUL AS AN OPHTHALMIC VEHICLE AND PROCEDURE FOR ITS PREPARATION.
DE19537012A1 (en) * 1995-10-04 1997-04-10 Dietl Hans Pharmaceutical preparation containing cyclosporin (s) for oral administration and process for its preparation
GB9601120D0 (en) * 1996-01-19 1996-03-20 Sandoz Ltd Organic compounds
US5660858A (en) * 1996-04-03 1997-08-26 Research Triangle Pharmaceuticals Cyclosporin emulsions

Also Published As

Publication number Publication date
DE19810655A1 (en) 1999-09-16
DE59912782D1 (en) 2005-12-22
EP0945136A1 (en) 1999-09-29
ES2248935T3 (en) 2006-03-16
ATE309816T1 (en) 2005-12-15
EP0945136B1 (en) 2005-11-16
EP0945136B9 (en) 2006-07-26

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