DK0880594T3 - Retroviral vector and its use in gene therapy - Google Patents

Retroviral vector and its use in gene therapy

Info

Publication number
DK0880594T3
DK0880594T3 DK97901179T DK97901179T DK0880594T3 DK 0880594 T3 DK0880594 T3 DK 0880594T3 DK 97901179 T DK97901179 T DK 97901179T DK 97901179 T DK97901179 T DK 97901179T DK 0880594 T3 DK0880594 T3 DK 0880594T3
Authority
DK
Denmark
Prior art keywords
retroviral vector
vector
gene therapy
reimplantation
transduced
Prior art date
Application number
DK97901179T
Other languages
Danish (da)
Inventor
Alan John Kingsman
Susan Mary Kingsman
Original Assignee
Oxford Biomedica Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9601336.2A external-priority patent/GB9601336D0/en
Priority claimed from GBGB9620759.2A external-priority patent/GB9620759D0/en
Application filed by Oxford Biomedica Ltd filed Critical Oxford Biomedica Ltd
Application granted granted Critical
Publication of DK0880594T3 publication Critical patent/DK0880594T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

DNA sequences for creating replication defective retroviral vector producer cells either in vivo, or in vitro for reimplantation. The retroviral vector comprises at least one heterologous gene and functional env and gag-pol genes are absent from the vector so that retrovirus structural proteins are not expressed by the target cells infected and transduced by the vector.
DK97901179T 1996-01-23 1997-01-23 Retroviral vector and its use in gene therapy DK0880594T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9601336.2A GB9601336D0 (en) 1996-01-23 1996-01-23 Retrovirus
GBGB9620759.2A GB9620759D0 (en) 1996-10-04 1996-10-04 Retrovirus
PCT/GB1997/000210 WO1997027310A1 (en) 1996-01-23 1997-01-23 Retroviral vector and its use in gene therapy

Publications (1)

Publication Number Publication Date
DK0880594T3 true DK0880594T3 (en) 2002-12-16

Family

ID=26308512

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97901179T DK0880594T3 (en) 1996-01-23 1997-01-23 Retroviral vector and its use in gene therapy

Country Status (13)

Country Link
EP (1) EP0880594B1 (en)
JP (1) JP3535521B2 (en)
KR (1) KR19990087036A (en)
AT (1) ATE226638T1 (en)
AU (1) AU729934B2 (en)
CA (1) CA2243529A1 (en)
DE (1) DE69716581T2 (en)
DK (1) DK0880594T3 (en)
ES (1) ES2184059T3 (en)
NO (1) NO983375L (en)
NZ (1) NZ326429A (en)
PT (1) PT880594E (en)
WO (1) WO1997027310A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9803351D0 (en) 1998-02-17 1998-04-15 Oxford Biomedica Ltd Anti-viral vectors
US6500623B1 (en) * 1998-05-12 2002-12-31 Genecure Llp Replication defective HIV vaccine
US6958226B1 (en) 1998-09-11 2005-10-25 The Children's Medical Center Corp. Packaging cells comprising codon-optimized gagpol sequences and lacking lentiviral accessory proteins
CA2344208A1 (en) 2001-04-30 2002-10-30 Oxford Biomedica (Uk) Limited Method
US20070036756A1 (en) * 2003-02-19 2007-02-15 Dnavec Research, Inc. Method for treating ischemic diseases
GB0526211D0 (en) * 2005-12-22 2006-02-01 Oxford Biomedica Ltd Viral vectors
GB0920775D0 (en) 2009-11-26 2010-01-13 King S College Cells
GB201415344D0 (en) 2014-08-29 2014-10-15 Ucl Business Plc Protein
GB201603374D0 (en) 2016-02-26 2016-04-13 Ucl Business Plc Packaging cell

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5834256A (en) * 1993-06-11 1998-11-10 Cell Genesys, Inc. Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells
FR2716459B1 (en) * 1994-02-22 1996-05-10 Univ Paris Curie Host-vector system usable in gene therapy.

Also Published As

Publication number Publication date
DE69716581T2 (en) 2003-03-06
EP0880594B1 (en) 2002-10-23
WO1997027310A1 (en) 1997-07-31
DE69716581D1 (en) 2002-11-28
AU729934B2 (en) 2001-02-15
JP2000500986A (en) 2000-02-02
ES2184059T3 (en) 2003-04-01
KR19990087036A (en) 1999-12-15
AU1452297A (en) 1997-08-20
EP0880594A1 (en) 1998-12-02
JP3535521B2 (en) 2004-06-07
PT880594E (en) 2003-03-31
NO983375D0 (en) 1998-07-22
ATE226638T1 (en) 2002-11-15
NO983375L (en) 1998-09-21
CA2243529A1 (en) 1997-07-31
NZ326429A (en) 2001-07-27

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