DK0853628T3 - Hidtil ukendte fotolabile 8-substituerede cycliske nukleotidestere, fremgangsmåde til fremstilling deraf og anvendelse deraf - Google Patents

Hidtil ukendte fotolabile 8-substituerede cycliske nukleotidestere, fremgangsmåde til fremstilling deraf og anvendelse deraf

Info

Publication number
DK0853628T3
DK0853628T3 DK96927617T DK96927617T DK0853628T3 DK 0853628 T3 DK0853628 T3 DK 0853628T3 DK 96927617 T DK96927617 T DK 96927617T DK 96927617 T DK96927617 T DK 96927617T DK 0853628 T3 DK0853628 T3 DK 0853628T3
Authority
DK
Denmark
Prior art keywords
esters
substituted
preparing
methods
cyclomonophosphate
Prior art date
Application number
DK96927617T
Other languages
English (en)
Inventor
Volker Hagen
Ulrich Benjamin Kaupp
Original Assignee
Forschungsverbund Berlin Ev
Forschungszentrum Juelich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungsverbund Berlin Ev, Forschungszentrum Juelich Gmbh filed Critical Forschungsverbund Berlin Ev
Application granted granted Critical
Publication of DK0853628T3 publication Critical patent/DK0853628T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK96927617T 1995-07-28 1996-07-29 Hidtil ukendte fotolabile 8-substituerede cycliske nukleotidestere, fremgangsmåde til fremstilling deraf og anvendelse deraf DK0853628T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19529025A DE19529025A1 (de) 1995-07-28 1995-07-28 Neue 8-bromsubstituierte cyclische Nucleotidester, Verfahren zu ihrer Herstellung und ihre Verwendung
PCT/EP1996/003317 WO1997005155A1 (de) 1995-07-28 1996-07-29 Neue photolabile 8-substituierte cyclische nucleotidester, verfahren zu ihrer herstellung und ihre verwendung

Publications (1)

Publication Number Publication Date
DK0853628T3 true DK0853628T3 (da) 2003-01-27

Family

ID=7768913

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96927617T DK0853628T3 (da) 1995-07-28 1996-07-29 Hidtil ukendte fotolabile 8-substituerede cycliske nukleotidestere, fremgangsmåde til fremstilling deraf og anvendelse deraf

Country Status (8)

Country Link
EP (1) EP0853628B1 (da)
JP (1) JPH11510149A (da)
AT (1) ATE225365T1 (da)
DE (3) DE19529025A1 (da)
DK (1) DK0853628T3 (da)
ES (1) ES2184886T3 (da)
PT (1) PT853628E (da)
WO (1) WO1997005155A1 (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10021256A1 (de) * 2000-04-20 2001-10-31 Forschungsverbund Berlin Ev Neue, photolabile Cumarinylmethylester von cyclischen Nucleotiden, Verfahren zu deren Herstellung und ihre Verwendung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1922172C3 (de) * 1969-04-30 1980-12-18 Boehringer Mannheim Gmbh, 6800 Mannheim S'-cycIophosphate
DE3027279A1 (de) * 1980-07-18 1982-05-06 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Substituierte adenosin-3',5'-phosphorsaeurebenzyltriester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
IT1202321B (it) * 1985-06-06 1989-02-02 Uni Degli Studi Di Parmo Nucleotidi ciclici fluorescenti biologicamente attivi
GB8529684D0 (en) * 1985-12-02 1986-01-08 Medical Res Council Photo-labile protecting agents

Also Published As

Publication number Publication date
EP0853628B1 (de) 2002-10-02
WO1997005155A1 (de) 1997-02-13
DE19529025A1 (de) 1997-01-30
ES2184886T3 (es) 2003-04-16
DE59609761D1 (de) 2002-11-07
JPH11510149A (ja) 1999-09-07
ATE225365T1 (de) 2002-10-15
PT853628E (pt) 2003-02-28
DE19680613D2 (de) 1998-06-18
EP0853628A1 (de) 1998-07-22

Similar Documents

Publication Publication Date Title
ES2118593T3 (es) Analogos de nucleotidos de pteridina como sondas fluorescentes de adn.
NO873753D0 (no) Periodisk biologisk luftbehandlingsprosess og system for denne.
AU9058091A (en) Preparation of nucleic acid samples
BR9608558A (pt) Processos e usos de fator de crescimento de tecido conjuntivo como um agente de indução
ES2118069T3 (es) Profarmacos de fosfonatos.
BR9811045A (pt) Composição de análogo de nucleotìdeo e processo de sìntese
AU5720498A (en) Chemical synthesis of nucleosides analogs and their incorporation into polynucleotides
JPH0359914B2 (da)
Parkes+ et al. A short synthesis of 3'-cyano-3'-deoxythxmidine
Sekine et al. Proton-block strategy for the synthesis of oligodeoxynucleotides without base protection, capping reaction, and P− N bond cleavage reaction
DE69815370D1 (de) Fluoreszend-konjugaten von nukleosiden und von nukleotiden, ihrer verfahren zur herstellung und ihrer verwendungen
DK0853628T3 (da) Hidtil ukendte fotolabile 8-substituerede cycliske nukleotidestere, fremgangsmåde til fremstilling deraf og anvendelse deraf
DE69401698D1 (de) Verfahren zur Herstellung von 2',3'-didehydro-2'3'-didesoxynukleosiden im Grossmassstab
DE3575730D1 (de) Modifizierte adeninegruppe enthaltende sonde, ihre herstellung und verwendungen.
DE69019920D1 (de) Benzocycloalkylaminopyridinamine und verwandte Verbindungen, Verfahren zu ihrer Herstellung, Zwischenverbindungen und ihre Verwendung als Arzneimittel.
Ohtsuka et al. Polynucleotides. VIII. New method for the synthesis of protected deoxyribooligonucleotides with 5'-phosphate
FI925457A (fi) Receptor av den ciliaera neurotrofiska faktorn
GR3021418T3 (en) Identification of novel drugs and reagents.
Michigami et al. Synthesis of novel nucleosides and stereoselectivity of N-glycosidation
Hassan et al. Nucleosides and Nucleotides. 151. Conversion of (Z)-2 ‘-(Cyanomethylene)-2 ‘-deoxyuridines into Their (E)-Isomers via Addition of Thiophenol to the Cyanomethylene Moiety Followed by Oxidative Syn-elimination Reactions1
ATE238419T1 (de) Atp-empfindliche kaliumkanal proteine und genen dafür
DK21790D0 (da) Eksoterme kemiske reaktionsprocesser
Grajkowski et al. An Improved Strategy for the Chemical Synthesis of 3′, 5′‐Cyclic Diguanylic Acid
NO913626L (no) Fremgangsmaate for kjemisk syntese av oligonukleotider.
National Research Council et al. The funding of young investigators in the biological and biomedical sciences