DK0819136T3 - Derivatives and Conjugates of MDP, which Have an Activity Stimulating Hematopoietic Function and Preparation Containing These - Google Patents

Derivatives and Conjugates of MDP, which Have an Activity Stimulating Hematopoietic Function and Preparation Containing These

Info

Publication number
DK0819136T3
DK0819136T3 DK96912079T DK96912079T DK0819136T3 DK 0819136 T3 DK0819136 T3 DK 0819136T3 DK 96912079 T DK96912079 T DK 96912079T DK 96912079 T DK96912079 T DK 96912079T DK 0819136 T3 DK0819136 T3 DK 0819136T3
Authority
DK
Denmark
Prior art keywords
mdp
conjugates
derivatives
preparation containing
hematopoietic function
Prior art date
Application number
DK96912079T
Other languages
Danish (da)
Inventor
Georges Bahr
Pierre Lefrancier
Louis Chedid
Original Assignee
Vacsyn Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vacsyn Sa filed Critical Vacsyn Sa
Application granted granted Critical
Publication of DK0819136T3 publication Critical patent/DK0819136T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A pharmaceutical composition for stimulating the haematopoietic function and preventing the myelotoxic side-effects of some treatments, containing at least one water-soluble muramyl peptide derivative such as Muradimetide, muroctasine or MTP-PE.
DK96912079T 1995-04-07 1996-04-05 Derivatives and Conjugates of MDP, which Have an Activity Stimulating Hematopoietic Function and Preparation Containing These DK0819136T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9504194A FR2732604B1 (en) 1995-04-07 1995-04-07 DERIVATIVES AND CONJUGATES OF MDP HAVING STIMULATORY ACTIVITY OF HEMATOPOIETIC FUNCTION AND COMPOSITIONS CONTAINING THEM
PCT/FR1996/000527 WO1996031533A1 (en) 1995-04-07 1996-04-05 Mdp derivatives and conjugates having haematopoietic function stimulating activity, and compositions containing same

Publications (1)

Publication Number Publication Date
DK0819136T3 true DK0819136T3 (en) 2002-05-21

Family

ID=9477896

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96912079T DK0819136T3 (en) 1995-04-07 1996-04-05 Derivatives and Conjugates of MDP, which Have an Activity Stimulating Hematopoietic Function and Preparation Containing These

Country Status (11)

Country Link
EP (1) EP0819136B1 (en)
JP (2) JP3816522B2 (en)
AT (1) ATE212644T1 (en)
AU (1) AU5504696A (en)
CA (1) CA2216599A1 (en)
DE (1) DE69618942T2 (en)
DK (1) DK0819136T3 (en)
ES (1) ES2171665T3 (en)
FR (1) FR2732604B1 (en)
PT (1) PT819136E (en)
WO (1) WO1996031533A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9618673D0 (en) * 1996-09-06 1996-10-16 Peptech Uk Ltd The use of muramyl peptides
PE20100362A1 (en) * 2008-10-30 2010-05-27 Irm Llc PURINE DERIVATIVES THAT EXPAND HEMATOPOYETIC STEM CELLS
CN103118691B (en) 2010-08-23 2016-08-24 康干细胞生物科技有限公司 Prevent and treat immune disorders and the stem cell including processing of inflammatory diseases or the pharmaceutical composition of its culture with NOD2 agonist

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2343483A1 (en) * 1976-03-10 1977-10-07 Anvar Immunogical adjuvants for weak vaccine antigens - are (2)-acetamido-deoxy (D)-glucopyranosyl (D)-propionyl (L)-alanyl (D)-glutamic acid esters and (D)-isoglutamines
FR2522967B1 (en) * 1982-03-15 1986-03-07 Anvar CONJUGATES OF HAPTENES AND MURAMYL-PEPTIDES, WITH IMMUNOGENIC ACTIVITY AND COMPOSITIONS CONTAINING THEM
DE3367596D1 (en) * 1982-07-23 1987-01-02 Ciba Geigy Ag Muramyl peptides and method for their preparation
EP0192609A3 (en) * 1985-02-20 1988-04-27 Ciba-Geigy Ag Acylated hexose derivatives and method for their preparation
FR2715305B1 (en) * 1994-01-25 1996-03-15 Vacsyn Sa Diesters of muramyl peptides in an oral form.

Also Published As

Publication number Publication date
JP3816522B2 (en) 2006-08-30
JP2006182785A (en) 2006-07-13
ES2171665T3 (en) 2002-09-16
DE69618942T2 (en) 2002-09-19
FR2732604B1 (en) 1997-06-06
FR2732604A1 (en) 1996-10-11
CA2216599A1 (en) 1996-10-10
EP0819136A1 (en) 1998-01-21
WO1996031533A1 (en) 1996-10-10
DE69618942D1 (en) 2002-03-14
AU5504696A (en) 1996-10-23
ATE212644T1 (en) 2002-02-15
PT819136E (en) 2002-07-31
JPH11503426A (en) 1999-03-26
EP0819136B1 (en) 2002-01-30

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