DK0804608T3 - Process for the preparation of polyvalent and physiologically degradable carbohydrate receptor blockers by enzymatic glyc - Google Patents

Process for the preparation of polyvalent and physiologically degradable carbohydrate receptor blockers by enzymatic glyc

Info

Publication number
DK0804608T3
DK0804608T3 DK95923321T DK95923321T DK0804608T3 DK 0804608 T3 DK0804608 T3 DK 0804608T3 DK 95923321 T DK95923321 T DK 95923321T DK 95923321 T DK95923321 T DK 95923321T DK 0804608 T3 DK0804608 T3 DK 0804608T3
Authority
DK
Denmark
Prior art keywords
receptor blockers
enzymatic
reactions
polyvalent
carbohydrate receptor
Prior art date
Application number
DK95923321T
Other languages
Danish (da)
Inventor
Brigitte Hirsch
Michael Ahlers
Gerhard Kretzschmar
Eckart Bartnik
Dirk Seiffge
Original Assignee
Glycorex Ab
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycorex Ab, Hoechst Ag filed Critical Glycorex Ab
Application granted granted Critical
Publication of DK0804608T3 publication Critical patent/DK0804608T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides

Abstract

The invention relates to a process for producing polyvalent polymer-based carbohydrate receptor blockers which in vivo do not, either in their complete form or when broken down, provoke intolerance reactions. The carbohydrate side chain of the receptor blocker is built up directly on the biodegradable polymer by enzymatic glycolisation reactions in aqueous buffer systems and homogenous phase; the yields of these glycolisation reactions are considerably better than those of known processes, generally progress quantitatively and the accumulation densities are markedly increased. Also proposed is a process for producing free oligosaccharides using the carbohydrate receptor blockers produced according to the invention.
DK95923321T 1994-06-16 1995-06-13 Process for the preparation of polyvalent and physiologically degradable carbohydrate receptor blockers by enzymatic glyc DK0804608T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4420943 1994-06-16
PCT/EP1995/002285 WO1995034673A1 (en) 1994-06-16 1995-06-13 Process for producing polyvalent and physiologically degradable carbohydrate receptor blockers by enzymatic glycosylation reactions, and uses thereof for manufacturing carbohydrate components

Publications (1)

Publication Number Publication Date
DK0804608T3 true DK0804608T3 (en) 1999-06-07

Family

ID=6520667

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95923321T DK0804608T3 (en) 1994-06-16 1995-06-13 Process for the preparation of polyvalent and physiologically degradable carbohydrate receptor blockers by enzymatic glyc

Country Status (8)

Country Link
EP (1) EP0804608B1 (en)
JP (1) JPH10503085A (en)
AT (1) ATE170567T1 (en)
CA (1) CA2192956A1 (en)
DE (1) DE59503469D1 (en)
DK (1) DK0804608T3 (en)
ES (1) ES2123994T3 (en)
WO (1) WO1995034673A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU570439B2 (en) * 1983-03-28 1988-03-17 Compression Labs, Inc. A combined intraframe and interframe transform coding system
EP0601417A3 (en) * 1992-12-11 1998-07-01 Hoechst Aktiengesellschaft Physiologically compatible and degradable polymer-based carbohydrate receptor blockers, a method for their preparation and their use

Also Published As

Publication number Publication date
ATE170567T1 (en) 1998-09-15
JPH10503085A (en) 1998-03-24
EP0804608B1 (en) 1998-09-02
ES2123994T3 (en) 1999-01-16
EP0804608A1 (en) 1997-11-05
CA2192956A1 (en) 1995-12-21
WO1995034673A1 (en) 1995-12-21
DE59503469D1 (en) 1998-10-08

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