DK0775488T3 - Stable pharmaceutical preparation based on acetylsalicylic acid and tocopherol - Google Patents

Stable pharmaceutical preparation based on acetylsalicylic acid and tocopherol

Info

Publication number
DK0775488T3
DK0775488T3 DK96402398T DK96402398T DK0775488T3 DK 0775488 T3 DK0775488 T3 DK 0775488T3 DK 96402398 T DK96402398 T DK 96402398T DK 96402398 T DK96402398 T DK 96402398T DK 0775488 T3 DK0775488 T3 DK 0775488T3
Authority
DK
Denmark
Prior art keywords
tocopherol
acetylsalicylic acid
pharmaceutical preparation
stable pharmaceutical
preparation based
Prior art date
Application number
DK96402398T
Other languages
Danish (da)
Inventor
Cyril Estanove
Alain Prudhomme
Original Assignee
Mazal Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mazal Pharma filed Critical Mazal Pharma
Application granted granted Critical
Publication of DK0775488T3 publication Critical patent/DK0775488T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Pharmaceutical capsules for oral administration contains crystalline or powdered acetylsalicylic acid (I) together with tocopherol (II) or one of its salts or esters, in the form of an oil. Preferably (I) is present in a form having a particle size < 500 mu m, the particles being optionally encapsulated in a cellulosic derivative. (II) may be alpha -, beta -, gamma - or delta -tocopherol in the d, l, or dl forms. Preferably d-, l-, or dl-tocopherol acetate is used. Each capsule contains 20-300 mg (I) and 20-600 mg (II).
DK96402398T 1995-11-23 1996-11-12 Stable pharmaceutical preparation based on acetylsalicylic acid and tocopherol DK0775488T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9513933A FR2741534B1 (en) 1995-11-23 1995-11-23 STABLE PHARMACEUTICAL COMPOSITION BASED ON ACETYLSALICYLIC ACID AND TOCOPHEROL

Publications (1)

Publication Number Publication Date
DK0775488T3 true DK0775488T3 (en) 2006-02-13

Family

ID=9484850

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96402398T DK0775488T3 (en) 1995-11-23 1996-11-12 Stable pharmaceutical preparation based on acetylsalicylic acid and tocopherol

Country Status (9)

Country Link
EP (1) EP0775488B1 (en)
JP (1) JPH09263538A (en)
AT (1) ATE306259T1 (en)
CA (1) CA2190807C (en)
DE (1) DE69635262T2 (en)
DK (1) DK0775488T3 (en)
ES (1) ES2249777T3 (en)
FR (1) FR2741534B1 (en)
SI (1) SI0775488T1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE493993T1 (en) * 2002-03-26 2011-01-15 Tsutomu Kagiya CHROMANOL GLUCOSIDE TO IMPROVE CHEMICAL CANCER TREATMENT
JP2008534591A (en) * 2005-03-29 2008-08-28 マクニール−ピーピーシー・インコーポレーテツド Composition having a hydrophilic drug in a hydrophobic solvent
DE102005025283A1 (en) * 2005-06-02 2006-12-07 Bayer Healthcare Ag Stable complex of salts of o-acetylsalicylic acid with basic amino acids and glycine

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2486541A (en) 1946-07-19 1949-11-01 Distillation Products Inc Delta-tocopherol
US2890240A (en) 1956-03-28 1959-06-09 Monsanto Chemicals Aspirin crystallisation
US3341416A (en) * 1963-12-11 1967-09-12 Ncr Co Encapsulation of aspirin in ethylcellulose and its product
US3235583A (en) 1964-07-22 1966-02-15 Norwich Pharma Co Preparation of aspirin
US3488418A (en) * 1965-11-18 1970-01-06 Sterling Drug Inc Sustained relief analgesic composition
JPS5438164B2 (en) * 1972-05-29 1979-11-19
US4454112A (en) 1977-12-27 1984-06-12 Henkel Corporation Sunscreen composition containing tocopherol acetylsalicylate
WO1984000004A1 (en) * 1982-06-14 1984-01-05 Key Pharma Sustained release aspirin
EP0204987B1 (en) * 1985-05-15 1991-11-21 Roshdy Dr. Ismail Medicine containing vitamin e for improving the properties of blood
EP0669132A1 (en) * 1994-02-23 1995-08-30 van der Kraaij, Antonius Marinus Maria Pharmaceutical composition of vitamin E and acetylsalicylate for treatment and prevention of atherosclerosis

Also Published As

Publication number Publication date
FR2741534A1 (en) 1997-05-30
EP0775488A1 (en) 1997-05-28
JPH09263538A (en) 1997-10-07
CA2190807C (en) 2007-07-10
EP0775488B1 (en) 2005-10-12
FR2741534B1 (en) 1998-09-11
CA2190807A1 (en) 1997-05-24
ATE306259T1 (en) 2005-10-15
ES2249777T3 (en) 2006-04-01
DE69635262T2 (en) 2006-07-13
SI0775488T1 (en) 2006-02-28
DE69635262D1 (en) 2006-02-23

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