DK0748190T3 - Progestogen-free formulations of GnRH and estrogen for the treatment of benign gynecological disorders - Google Patents

Progestogen-free formulations of GnRH and estrogen for the treatment of benign gynecological disorders

Info

Publication number
DK0748190T3
DK0748190T3 DK94917349T DK94917349T DK0748190T3 DK 0748190 T3 DK0748190 T3 DK 0748190T3 DK 94917349 T DK94917349 T DK 94917349T DK 94917349 T DK94917349 T DK 94917349T DK 0748190 T3 DK0748190 T3 DK 0748190T3
Authority
DK
Denmark
Prior art keywords
progestogen
gnrh
estrogen
treatment
gynecological disorders
Prior art date
Application number
DK94917349T
Other languages
Danish (da)
Inventor
Malcolm Cecil Pike
Darcy Vernon Spicer
Original Assignee
Univ Southern California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Southern California filed Critical Univ Southern California
Application granted granted Critical
Publication of DK0748190T3 publication Critical patent/DK0748190T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/14—Topical contraceptives and spermacides

Abstract

Compositions and methods which are effective to treat benign gynecological disorders for extended periods of time in women in who the risk of endometrial stimulation is minimized or absent are described, wherein an effective amount of a gonadotropin hormone releasing hormone composition and an effective amount of an estrogenic composition are provided over a period of time, optionally with addition of an androgenic composition.
DK94917349T 1993-05-17 1994-05-12 Progestogen-free formulations of GnRH and estrogen for the treatment of benign gynecological disorders DK0748190T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/062,883 US5340585A (en) 1991-04-12 1993-05-17 Method and formulations for use in treating benign gynecological disorders
PCT/US1994/005222 WO1994026207A1 (en) 1993-05-17 1994-05-12 Methods and formulations for use in treating benign gynecological disorders

Publications (1)

Publication Number Publication Date
DK0748190T3 true DK0748190T3 (en) 2003-10-27

Family

ID=22045464

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94917349T DK0748190T3 (en) 1993-05-17 1994-05-12 Progestogen-free formulations of GnRH and estrogen for the treatment of benign gynecological disorders

Country Status (10)

Country Link
US (1) US5340585A (en)
EP (1) EP0748190B1 (en)
AT (1) ATE245992T1 (en)
CA (1) CA2162261A1 (en)
DE (1) DE69432990T2 (en)
DK (1) DK0748190T3 (en)
ES (1) ES2204917T3 (en)
NO (1) NO321502B1 (en)
PT (1) PT748190E (en)
WO (1) WO1994026207A1 (en)

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Also Published As

Publication number Publication date
NO954611L (en) 1996-01-16
PT748190E (en) 2003-12-31
EP0748190B1 (en) 2003-07-30
US5340585A (en) 1994-08-23
DE69432990D1 (en) 2003-09-04
EP0748190A4 (en) 1998-06-10
CA2162261A1 (en) 1994-11-24
DE69432990T2 (en) 2004-04-22
ES2204917T3 (en) 2004-05-01
EP0748190A1 (en) 1996-12-18
ATE245992T1 (en) 2003-08-15
NO321502B1 (en) 2006-05-15
WO1994026207A1 (en) 1994-11-24
NO954611D0 (en) 1995-11-15

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