DK0693071T3 - New carboxylic acid esters of 2-amino-7- (1,3-dihydroxy-2-propoxymethyl) purine, their preparation and their use - Google Patents

New carboxylic acid esters of 2-amino-7- (1,3-dihydroxy-2-propoxymethyl) purine, their preparation and their use

Info

Publication number
DK0693071T3
DK0693071T3 DK94912542T DK94912542T DK0693071T3 DK 0693071 T3 DK0693071 T3 DK 0693071T3 DK 94912542 T DK94912542 T DK 94912542T DK 94912542 T DK94912542 T DK 94912542T DK 0693071 T3 DK0693071 T3 DK 0693071T3
Authority
DK
Denmark
Prior art keywords
propoxymethyl
purine
dihydroxy
amino
preparation
Prior art date
Application number
DK94912542T
Other languages
Danish (da)
Inventor
Gerhard Jaehne
Matthias Helsberg
Irvin Winkler
Gerhard Gross
Thomas Scholl
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0693071T3 publication Critical patent/DK0693071T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Abstract

The invention concerns compounds of formula (1) in which the substituents R<1> and R<2> are as defined in the description. Such compounds exhibit an antiviral action and high bio-availability following oral administration.
DK94912542T 1993-04-09 1994-03-24 New carboxylic acid esters of 2-amino-7- (1,3-dihydroxy-2-propoxymethyl) purine, their preparation and their use DK0693071T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4311801A DE4311801A1 (en) 1993-04-09 1993-04-09 New carboxylic acid esters of 2-amino-7- (1,3-dihydroxy-2-propoxymethyl) purine, their preparation and their use
PCT/EP1994/000951 WO1994024134A1 (en) 1993-04-09 1994-03-24 New carboxylic-acid esters of 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, the preparation of such esters and their use

Publications (1)

Publication Number Publication Date
DK0693071T3 true DK0693071T3 (en) 1998-08-10

Family

ID=6485206

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94912542T DK0693071T3 (en) 1993-04-09 1994-03-24 New carboxylic acid esters of 2-amino-7- (1,3-dihydroxy-2-propoxymethyl) purine, their preparation and their use

Country Status (9)

Country Link
EP (1) EP0693071B1 (en)
JP (1) JPH08508508A (en)
AT (1) ATE161011T1 (en)
AU (1) AU6505294A (en)
DE (2) DE4311801A1 (en)
DK (1) DK0693071T3 (en)
ES (1) ES2111297T3 (en)
GR (1) GR3025797T3 (en)
WO (1) WO1994024134A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
SE9800452D0 (en) * 1998-02-13 1998-02-13 Medivir Ab antivirals
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
CA2271135A1 (en) * 1996-11-12 1998-05-22 Medivir Ab Nucleosides
CZ300757B6 (en) * 1997-08-15 2009-08-05 Medivir Ab Nucleoside analogs, such as antiviral agents containing inhibitors of retroviral reverse transcriptase and DNA polymerase of hepatitis B virus (HBV)
WO1999032490A1 (en) * 1997-12-19 1999-07-01 Bristol-Myers Squibb Company Prodrugs of lobucavir and methods of use
TWI332507B (en) 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4008858A1 (en) * 1990-03-20 1991-09-26 Hoechst Ag New substd. purine antiviral cpds.
DE4210221A1 (en) * 1992-03-28 1993-09-30 Hoechst Ag Carboxylic acid esters of 2-amino-7- (1,3-dihydroxy-2-propoxymethyl) purine, their preparation and their use

Also Published As

Publication number Publication date
ES2111297T3 (en) 1998-03-01
JPH08508508A (en) 1996-09-10
EP0693071B1 (en) 1997-12-10
EP0693071A1 (en) 1996-01-24
AU6505294A (en) 1994-11-08
ATE161011T1 (en) 1997-12-15
DE4311801A1 (en) 1994-10-13
DE59404784D1 (en) 1998-01-22
WO1994024134A1 (en) 1994-10-27
GR3025797T3 (en) 1998-03-31

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