DK0610076T3 - Cytotoxic compounds - Google Patents
Cytotoxic compoundsInfo
- Publication number
- DK0610076T3 DK0610076T3 DK94300778T DK94300778T DK0610076T3 DK 0610076 T3 DK0610076 T3 DK 0610076T3 DK 94300778 T DK94300778 T DK 94300778T DK 94300778 T DK94300778 T DK 94300778T DK 0610076 T3 DK0610076 T3 DK 0610076T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- cytotoxic compounds
- mpta
- antitumor
- formulae
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 231100000433 cytotoxic Toxicity 0.000 title 1
- 230000001472 cytotoxic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
- C07C59/11—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/02—1,2-Dioxanes; Hydrogenated 1,2-dioxanes
Abstract
Compounds isolated from a marine sponge, and derivatives thereof, have the formulae: <CHEM> in which R<1> is H or lower alkyl; R<2> is OH or CH3; R<3> is OH or CH<3>, and R<4> H or MPTA. The compounds have antitumor and antiviral activity. The invention also provides pharmaceutical compositions containing the compounds and methods of treatment employing them.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939302044A GB9302044D0 (en) | 1993-02-03 | 1993-02-03 | Cytotoxic compounds i |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0610076T3 true DK0610076T3 (en) | 1999-01-25 |
Family
ID=10729726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94300778T DK0610076T3 (en) | 1993-02-03 | 1994-02-02 | Cytotoxic compounds |
Country Status (11)
Country | Link |
---|---|
US (1) | US5449684A (en) |
EP (1) | EP0610076B1 (en) |
JP (1) | JPH0769884A (en) |
AT (1) | ATE165094T1 (en) |
AU (1) | AU674366B2 (en) |
CA (1) | CA2114777A1 (en) |
DE (1) | DE69409553T2 (en) |
DK (1) | DK0610076T3 (en) |
ES (1) | ES2116522T3 (en) |
GB (1) | GB9302044D0 (en) |
ZA (1) | ZA94746B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6541515B2 (en) * | 2000-08-09 | 2003-04-01 | Merck & Co., Inc. | HIV integrase inhibitors |
JOP20190254A1 (en) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | Antitumoral compounds |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4731377A (en) * | 1986-01-31 | 1988-03-15 | Harbor Branch Oceanographic Institute, Inc. | Antitumor cyclic peroxides |
US5183924A (en) * | 1989-01-24 | 1993-02-02 | Lipha, Lyonnaise Industrielle Pharmaceutique | Derivatives of benzocycloalkenyldihydroxyalkanoic acids, processes of preparation and medications containing them |
-
1993
- 1993-02-03 GB GB939302044A patent/GB9302044D0/en active Pending
-
1994
- 1994-02-02 DK DK94300778T patent/DK0610076T3/en active
- 1994-02-02 ES ES94300778T patent/ES2116522T3/en not_active Expired - Lifetime
- 1994-02-02 AT AT94300778T patent/ATE165094T1/en not_active IP Right Cessation
- 1994-02-02 EP EP94300778A patent/EP0610076B1/en not_active Expired - Lifetime
- 1994-02-02 DE DE69409553T patent/DE69409553T2/en not_active Expired - Fee Related
- 1994-02-02 CA CA002114777A patent/CA2114777A1/en not_active Abandoned
- 1994-02-03 ZA ZA94746A patent/ZA94746B/en unknown
- 1994-02-03 JP JP6043023A patent/JPH0769884A/en active Pending
- 1994-02-03 AU AU54910/94A patent/AU674366B2/en not_active Ceased
- 1994-02-03 US US08/191,336 patent/US5449684A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0610076B1 (en) | 1998-04-15 |
AU674366B2 (en) | 1996-12-19 |
ATE165094T1 (en) | 1998-05-15 |
GB9302044D0 (en) | 1993-03-24 |
EP0610076A1 (en) | 1994-08-10 |
ES2116522T3 (en) | 1998-07-16 |
AU5491094A (en) | 1994-08-11 |
DE69409553D1 (en) | 1998-05-20 |
JPH0769884A (en) | 1995-03-14 |
ZA94746B (en) | 1994-09-29 |
CA2114777A1 (en) | 1994-08-04 |
DE69409553T2 (en) | 1998-10-15 |
US5449684A (en) | 1995-09-12 |
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