DK0609031T3 - Process for the preparation of benzothiazepine derivatives - Google Patents

Process for the preparation of benzothiazepine derivatives

Info

Publication number
DK0609031T3
DK0609031T3 DK94300447.3T DK94300447T DK0609031T3 DK 0609031 T3 DK0609031 T3 DK 0609031T3 DK 94300447 T DK94300447 T DK 94300447T DK 0609031 T3 DK0609031 T3 DK 0609031T3
Authority
DK
Denmark
Prior art keywords
compound
aminoalkylamino
preparation
ester
benzothiazepine derivatives
Prior art date
Application number
DK94300447.3T
Other languages
Danish (da)
Inventor
Teruo Yamamori
Hiroshi Harada
Eiichi Oosugi
Katsunori Sakai
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Application granted granted Critical
Publication of DK0609031T3 publication Critical patent/DK0609031T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Abstract

Process for stereoselectivity preparing a cis-form of 5-(aminoalkylamino)-1,5-benzothiazepine derivative represented by formula (VI): <CHEM> is provided, said process comprising carrying out a stereoselective addition reaction of an o-(aminoalkylamino)thiophenyl derivative with a trans-substituted glycidic ester at an elevated temperature in a nonpolar solvent in the presence of a divalent or trivalent iron ion to prepare a threo-form intermediate, hydrolyzing the ester group of said intermediate, acetylating the hydroxyl group of said hydrolyzed compound, and subjecting said acetylated compound to a ring closure reaction to obtain the objective compound (VI).
DK94300447.3T 1993-01-27 1994-01-20 Process for the preparation of benzothiazepine derivatives DK0609031T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1149293 1993-01-27

Publications (1)

Publication Number Publication Date
DK0609031T3 true DK0609031T3 (en) 1997-10-27

Family

ID=11779543

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94300447.3T DK0609031T3 (en) 1993-01-27 1994-01-20 Process for the preparation of benzothiazepine derivatives

Country Status (16)

Country Link
US (1) US5473066A (en)
EP (1) EP0609031B1 (en)
JP (1) JPH06279398A (en)
KR (2) KR100292313B1 (en)
CN (1) CN1040751C (en)
AT (1) ATE156809T1 (en)
AU (1) AU665887B2 (en)
CA (1) CA2114036A1 (en)
DE (1) DE69404871T2 (en)
DK (1) DK0609031T3 (en)
ES (1) ES2106443T3 (en)
GR (1) GR3024738T3 (en)
HU (1) HUT70413A (en)
NO (1) NO304376B1 (en)
TW (1) TW252099B (en)
ZA (1) ZA94284B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19541717A1 (en) 1995-11-09 1997-05-15 Bayer Ag Process for the preparation of methyl (2RS, 3RS) -3- (2'-amino-phenylthio) -2-hydroxy-3- (4 "-methoxyphenyl) -propionate
IL123352A0 (en) 1997-02-27 1998-09-24 Tanabe Seiyaku Co Process for preparing an optically active trans-3-substituted glycidic acid ester
WO1998056762A2 (en) * 1997-06-11 1998-12-17 Tanabe Seiyaku Co., Ltd. Process for preparing optically active phenyloxirane compounds
US7704990B2 (en) * 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US9604926B2 (en) * 2007-08-16 2017-03-28 The University Of Mississippi Highly selective sigma receptor radioligands
US8686008B2 (en) * 2007-08-16 2014-04-01 The University Of Mississippi Highly selective sigma receptor ligands

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6058909B2 (en) * 1980-02-01 1985-12-23 田辺製薬株式会社 Propionic acid derivatives and their production method
JPS59110668A (en) * 1982-12-17 1984-06-26 Tokawa Tetsuo Optical resolution of 2-substituted-3-(p-methoxy-phenyl)-3- ((2-substituted)phenylthio)propionic acid
JPS59110685A (en) * 1982-12-17 1984-06-26 Tokawa Tetsuo Preparation of optically active benzothiazepine derivative
JPS60146884A (en) * 1984-01-09 1985-08-02 Nippon Chem:Kk Production of 1,5-benzothiazepine derivative
JPH01128974A (en) * 1987-11-13 1989-05-22 Tanabe Seiyaku Co Ltd Production of 1,5-benzothiazepin derivative
FR2723192B1 (en) * 1989-05-18 1996-10-04 Creusot Loire Ind Sa SHIELDING ELEMENT FOR VEHICLES
US5001236A (en) * 1989-11-22 1991-03-19 Marion Laboratories, Inc. Benzothiazepines

Also Published As

Publication number Publication date
CN1040751C (en) 1998-11-18
US5473066A (en) 1995-12-05
AU665887B2 (en) 1996-01-18
KR100307335B1 (en) 2001-09-24
HUT70413A (en) 1995-10-30
ZA94284B (en) 1994-08-17
CN1096782A (en) 1994-12-28
NO940272D0 (en) 1994-01-26
CA2114036A1 (en) 1994-07-28
DE69404871T2 (en) 1998-03-19
EP0609031A1 (en) 1994-08-03
NO304376B1 (en) 1998-12-07
TW252099B (en) 1995-07-21
ES2106443T3 (en) 1997-11-01
NO940272L (en) 1994-07-28
KR940018369A (en) 1994-08-16
DE69404871D1 (en) 1997-09-18
GR3024738T3 (en) 1997-12-31
ATE156809T1 (en) 1997-08-15
KR100292313B1 (en) 2001-09-17
EP0609031B1 (en) 1997-08-13
AU5470394A (en) 1994-08-04
JPH06279398A (en) 1994-10-04
HU9400226D0 (en) 1994-05-30

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