DK0605497T3 - Solid lipid drug carrier (solid lipid nanospheres (SLN)) - Google Patents

Solid lipid drug carrier (solid lipid nanospheres (SLN))

Info

Publication number
DK0605497T3
DK0605497T3 DK92919477.7T DK92919477T DK0605497T3 DK 0605497 T3 DK0605497 T3 DK 0605497T3 DK 92919477 T DK92919477 T DK 92919477T DK 0605497 T3 DK0605497 T3 DK 0605497T3
Authority
DK
Denmark
Prior art keywords
solid lipid
sln
drug carrier
nanospheres
solid
Prior art date
Application number
DK92919477.7T
Other languages
Danish (da)
Other versions
DK0605497T4 (en
Inventor
Stefan Lucks
Rainer Mueller
Original Assignee
Medac Klinische Spezialpraep
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6441225&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0605497(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medac Klinische Spezialpraep filed Critical Medac Klinische Spezialpraep
Publication of DK0605497T3 publication Critical patent/DK0605497T3/en
Application granted granted Critical
Publication of DK0605497T4 publication Critical patent/DK0605497T4/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Medication vehicles have particles made of lipids, lipid-like (lipoid) materials or mixtures thereof, with a diameter from 10 nm to 10 $g(m)m, that are solid at the ambient temperature. Because or their solid core, these medication vehicles allow active substances to be controllably released over a longer period, allow hydrophilic medicaments to be incorporated into the solid core and are relatively quickly decomposable, producing no toxic by-products.
DK92919477T 1991-09-18 1992-09-16 Solid lipid drug carrier (solid lipid nanospheres (SLN)) DK0605497T4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4131562A DE4131562A1 (en) 1991-09-18 1991-09-18 SOLID LIPID PARTICLE SOLID LIPID NANOSPHERES (SLN)
PCT/EP1992/002132 WO1993005768A1 (en) 1991-09-18 1992-09-16 Medication vehicles made of solid lipid particles (solid lipid nanospheres - sln)

Publications (2)

Publication Number Publication Date
DK0605497T3 true DK0605497T3 (en) 1996-08-05
DK0605497T4 DK0605497T4 (en) 1999-10-25

Family

ID=6441225

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92919477T DK0605497T4 (en) 1991-09-18 1992-09-16 Solid lipid drug carrier (solid lipid nanospheres (SLN))

Country Status (13)

Country Link
EP (1) EP0605497B2 (en)
JP (1) JP2683575B2 (en)
KR (1) KR0141504B1 (en)
AT (1) ATE135567T1 (en)
AU (1) AU672177B2 (en)
CA (1) CA2119253C (en)
CZ (1) CZ289253B6 (en)
DE (2) DE4131562A1 (en)
DK (1) DK0605497T4 (en)
ES (1) ES2085035T5 (en)
GR (2) GR3019750T3 (en)
HU (1) HU227680B1 (en)
WO (1) WO1993005768A1 (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4308282C2 (en) * 1993-03-16 1994-12-22 Beiersdorf Ag Galenic matrices preferably in the form of microspheres
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
DE4336407A1 (en) * 1993-10-21 1995-04-27 Rotring Int Gmbh Waterproof cosmetics
JPH11504631A (en) * 1995-04-25 1999-04-27 バイカル インコーポレイテッド Single vial formulation of DNA / lipid complex
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
EP1010435B1 (en) * 1997-09-05 2010-11-03 Maruho K.K. Nanocapsule preparations for treating intraarticular diseases
IT1296914B1 (en) * 1997-12-01 1999-08-03 Maria Rosa Gasco PHARMACEUTICAL COMPOSITION INCLUDING MICROPARTICLES SUITABLE FOR TRANSMUCOSAL PASSAGE AND OVERCOMING THE BARRIER
CN1245955C (en) 1998-05-29 2006-03-22 斯凯伊药品加拿大公司 Thermoprotected microparticle compositions and process for terminal steam sterilization thereof
US7939105B2 (en) 1998-11-20 2011-05-10 Jagotec Ag Process for preparing a rapidly dispersing solid drug dosage form
DE19856432A1 (en) 1998-12-08 2000-06-15 Basf Ag Nanoparticulate core-shell systems and their use in pharmaceutical and cosmetic preparations
US8663692B1 (en) 1999-05-07 2014-03-04 Pharmasol Gmbh Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
DE60005819T2 (en) 1999-06-14 2004-05-06 Cosmo S.P.A. TASTE-MASKED ORAL PHARMACEUTICAL COMPOSITIONS WITH CONTROLLED DELIVERY
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
US6814959B1 (en) * 1999-07-13 2004-11-09 Pharmasol Gmbh UV radiation reflecting or absorbing agents, protecting against harmful UV radiation and reinforcing the natural skin barrier
EP1322343A4 (en) * 2000-09-29 2006-08-16 Salvona Llc Multi component controlled release system for sanitary paper products
EP1269994A3 (en) 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
KR20010090030A (en) * 2001-08-09 2001-10-18 임정옥 Manufacturing and synergic effect of topical anesthetic formula consisted of mixed local anesthetics
KR100452165B1 (en) * 2002-01-29 2004-10-08 주식회사 태평양 Oil-in-Water type nano-emulsion comprising a lecithin and an anionic surfactant for cosmetic, dermatological, and pharmaceutical vehicles containing thereof
DE10312763A1 (en) 2003-03-21 2004-09-30 IFAC Institut für angewandte Colloidtechnologie GmbH & Co. KG Process for the preparation of an SLN dispersion
FR2852843B1 (en) 2003-03-24 2008-05-23 Karim Ioualalen GALENIC SYSTEM FOR MASKING TASTE
JP4452187B2 (en) 2003-05-07 2010-04-21 イーファック・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・ウント・コンパニー・コマンディートゲゼルシャフト Composition for targeted release of fragrances and aromas
FR2864900B1 (en) * 2004-01-09 2007-10-12 Oreal AQUEOUS DISPERSION OF NANOCAPSULES WITH OILY HEART
MXPA06010950A (en) * 2004-03-26 2007-04-16 Cell Therapeutics Europe Srl Nanoparticle formulations of platinum compounds.
EP1674081A1 (en) 2004-12-23 2006-06-28 KTB Tumorforschungsgesellschaft mbH Preparation of lipid based nano-particles with a dual asymetric centrifuge
JP4533185B2 (en) * 2005-02-24 2010-09-01 花王株式会社 Solid lipid particle formulation
JP5483874B2 (en) * 2005-05-05 2014-05-07 サノフィ−アベンティス・ユー・エス・エルエルシー Stable nanoparticle formulation
PL1940905T3 (en) 2005-10-25 2011-02-28 Evonik Degussa Gmbh Preparations containing hyperbranched polymers
ITMI20061274A1 (en) * 2006-06-30 2008-01-01 Consiglio Nazionale Ricerche LIPID NANOPARTICELLAR VECTORS CONTAINING RELIEF AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
CA2669392C (en) 2006-11-17 2016-05-10 Abbott Gmbh & Co. Kg Nanocrystals for use in topical cosmetic formulations and method of production thereof
EP1982698A1 (en) * 2007-04-18 2008-10-22 Evonik Degussa GmbH Preparations for controlled release of natural bioactive materials
EP2108361A1 (en) * 2008-04-09 2009-10-14 ROVI Cosmetics International GmbH Emulgating microparticles made of lipids for stabilising lipophilic agents for cosmetic use
EP2218447B1 (en) 2008-11-04 2017-04-19 PharmaSol GmbH Compositions containing lipid micro- or nanoparticles for the enhancement of the dermal action of solid particles
FR2950253B1 (en) 2009-09-24 2011-09-23 Ethypharm Sa LIPID NANOCAPSULES, PREPARATION METHOD AND USE AS MEDICAMENT
ES2384060B1 (en) 2010-03-24 2013-09-23 Lipotec S.A. LIPID NANOPARTICLES CAPSULES.
GB201021937D0 (en) * 2010-12-24 2011-02-02 Reckitt & Colman Overseas Skin sanitizer compositions comprising alcohol based emulsion
CN103459008B (en) 2010-12-28 2015-08-19 荷兰联合利华有限公司 The method of emulsification
KR20140031227A (en) * 2011-03-24 2014-03-12 레오 파마 에이/에스 A composition comprising lipid nanoparticles and a corticosteroid or vitamin d derivative
DE102011018499A1 (en) 2011-04-23 2012-10-25 Emc Microcollections Gmbh Topical nanoparticle vaccine for the immune stimulation of dendritic cells in the skin
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
DE102011116069A1 (en) 2011-10-18 2013-04-18 Dr. Rimpler Gmbh Lipid nanoparticle dispersion, process for its preparation and its use
ITBO20130376A1 (en) 2013-07-18 2015-01-19 Ferbi Srl METHOD FOR THE PREPARATION OF SOLID LIPID NANOPARTICLES CONTAINING ANTIBODIES IN THE FORM OF A IONIAN COUPLE, THROUGH THE COACERVATION TECHNIQUE OF FATTY ACIDS
CA2970917C (en) * 2014-12-15 2019-09-17 Nanosphere Health Sciences, Llc Methods of treating inflammatory disorders and global inflammation with compositions comprising phospholipid nanoparticle encapsulations of nsaids
CA3089686A1 (en) 2015-03-10 2016-09-15 Nanosphere Health Sciences, Llc A nanoparticle drug delivery comprising liquid lipids and cannabinoids encapsulated in a single layer of essential phospholipids
CZ307681B6 (en) 2016-02-29 2019-02-13 Ústav makromolekulární chemie AV ČR, v. v. i. A photoactivatable nanoparticle for photodynamic applications, the method of its preparation, a pharmaceutical composition comprising it and their use
CA3085694A1 (en) 2017-12-12 2019-06-20 Lead Biotherapeutics Ltd. Solid lipid nanoparticle for intracellular release of active substances and method for production the same
US11504327B1 (en) 2019-01-21 2022-11-22 Eric Morrison Method of preparing nanoparticles by hot-melt extrusion
IT201900009258A1 (en) 2019-06-17 2020-12-17 R Bio Transfer S R L METHOD FOR THE PREPARATION OF LIPID NANOPARTICLES
IT201900013353A1 (en) 2019-07-30 2021-01-30 Univ Della Calabria Bergamot essential oil delivery system based on nanotechnologies, method of preparation of the system and its uses.
WO2023275648A1 (en) 2021-06-30 2023-01-05 Novocure Gmbh Compositions and methods for using alternating electric fields to disrupt lipid capsules
IT202100023570A1 (en) 2021-09-13 2023-03-13 Bioema S R L S Biotecnologia Energia Mat Ambiente METHOD FOR THE PREPARATION OF LIPID NANOPARTICLES
DE202023100649U1 (en) 2023-02-10 2023-03-22 Cineolux Gmbh Dispersion and preparation for topical use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3421468A1 (en) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim LIPID NANOPELLETS AS A CARRIER SYSTEM FOR MEDICINAL PRODUCTS FOR PERORAL USE
NZ231281A (en) * 1988-11-08 1991-01-29 Takeda Chemical Industries Ltd Sustained release pharmaceutical preparations comprising the active agent dispersed in a solid matrix of a fatty acid ester of a polyglycerol
LU87410A1 (en) * 1988-12-20 1990-07-10 Cird COSMETIC OR PHARMACEUTICAL COMPOSITION CONTAINING POLYMERIC OR FATTY BODY MICROSPHERES CHARGED WITH AT LEAST ONE ACTIVE PRODUCT
FR2651680B1 (en) * 1989-09-14 1991-12-27 Medgenix Group Sa NOVEL PROCESS FOR THE PREPARATION OF LIPID MICROPARTICLES.
FR2657257B1 (en) * 1990-01-19 1994-09-02 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF DRUGS IN THE FORM OF PEARLS.

Also Published As

Publication number Publication date
EP0605497B2 (en) 1999-04-14
AU672177B2 (en) 1996-09-26
JP2683575B2 (en) 1997-12-03
CZ289253B6 (en) 2001-12-12
WO1993005768A1 (en) 1993-04-01
HU9400779D0 (en) 1994-06-28
GR3030291T3 (en) 1999-09-30
AU2561592A (en) 1993-04-27
KR0141504B1 (en) 1998-06-01
DE59205783D1 (en) 1996-04-25
CA2119253C (en) 1998-11-03
JPH06510772A (en) 1994-12-01
ATE135567T1 (en) 1996-04-15
GR3019750T3 (en) 1996-07-31
ES2085035T5 (en) 1999-06-16
CA2119253A1 (en) 1993-04-01
CZ59694A3 (en) 1994-07-13
EP0605497A1 (en) 1994-07-13
ES2085035T3 (en) 1996-05-16
HU227680B1 (en) 2011-11-28
HUT75165A (en) 1997-04-28
DK0605497T4 (en) 1999-10-25
DE4131562A1 (en) 1993-03-25
EP0605497B1 (en) 1996-03-20

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