DK0580459T3 - Substituted phenylimidazolidines, their use as pharmaceuticals and pharmaceuticals containing them - Google Patents

Substituted phenylimidazolidines, their use as pharmaceuticals and pharmaceuticals containing them

Info

Publication number
DK0580459T3
DK0580459T3 DK93401361T DK93401361T DK0580459T3 DK 0580459 T3 DK0580459 T3 DK 0580459T3 DK 93401361 T DK93401361 T DK 93401361T DK 93401361 T DK93401361 T DK 93401361T DK 0580459 T3 DK0580459 T3 DK 0580459T3
Authority
DK
Denmark
Prior art keywords
pharmaceuticals
halogen
image
oxygen
substituted
Prior art date
Application number
DK93401361T
Other languages
Danish (da)
Inventor
Francois Goubet
Daniel Philibert
Martine Gaillard-Kelly
Jean-Georges Teutsch
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of DK0580459T3 publication Critical patent/DK0580459T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin

Abstract

The subject of the invention is the products of formula (I): <IMAGE> in which: R1 represents cyano, nitro or halogen, R2 represents trifluoromethyl or halogen, the -A-B- group is chosen from the radicals <IMAGE> in which X represents oxygen or sulphur and R3 is chosen from: - a hydrogen, - alkyl, alkenyl, alkynyl, aryl or arylalkyl, these radicals optionally being substituted, - trialkylsilyl, - acyl or acyloxy, Y represents oxygen or sulphur or NH, with the exception of the products in which: the -A-B- group represents the radical <IMAGE> in which X represents oxygen, R3 represents hydrogen, Y represents oxygen or NH, R2 represents halogen or trifluoromethyl and R1 represents nitro or halogen; the preparation and their application as medicaments, in particular as antiandrogens.
DK93401361T 1992-07-08 1993-05-28 Substituted phenylimidazolidines, their use as pharmaceuticals and pharmaceuticals containing them DK0580459T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR929208431A FR2693461B1 (en) 1992-07-08 1992-07-08 New substituted phenylimidazolidines, process for their preparation, their use as medicaments and the pharmaceutical compositions containing them.

Publications (1)

Publication Number Publication Date
DK0580459T3 true DK0580459T3 (en) 2001-06-11

Family

ID=9431679

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93401361T DK0580459T3 (en) 1992-07-08 1993-05-28 Substituted phenylimidazolidines, their use as pharmaceuticals and pharmaceuticals containing them

Country Status (17)

Country Link
EP (1) EP0580459B1 (en)
JP (1) JP3845455B2 (en)
KR (1) KR100294383B1 (en)
CN (1) CN1044234C (en)
AT (1) ATE200077T1 (en)
AU (1) AU670942B2 (en)
CA (1) CA2097248A1 (en)
DE (1) DE69330058T2 (en)
DK (1) DK0580459T3 (en)
ES (1) ES2155067T3 (en)
FR (1) FR2693461B1 (en)
GR (1) GR3035768T3 (en)
HU (1) HUT64527A (en)
PT (1) PT580459E (en)
RU (1) RU2116298C1 (en)
UA (1) UA34428C2 (en)
ZA (1) ZA933786B (en)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW521073B (en) * 1994-01-05 2003-02-21 Hoechst Marion Roussel Inc New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
FR2715402B1 (en) * 1994-01-05 1996-10-04 Roussel Uclaf New phenylimidazolines optionally substituted, their process and preparation intermediates, their use as medicaments and the pharmaceutical compositions containing them.
FR2724169B1 (en) * 1994-09-06 1997-01-03 Roussel Uclaf NOVEL PHENYLIMIDAZOLIDINES WHICH MAY BE SUBSTITUTED, THEIR PROCESS AND PREPARATION INTERMEDIATES, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2716110B1 (en) 1994-02-16 1996-04-05 Roussel Uclaf Cosmetic or pharmaceutical compositions comprising liposomes.
AU726572B2 (en) * 1994-02-16 2000-11-09 Aventis Pharma S.A. Cosmetics or pharmaceutical compositions consisting of liposomes
US5656651A (en) * 1995-06-16 1997-08-12 Biophysica Inc. Androgenic directed compositions
FR2741342B1 (en) * 1995-11-22 1998-02-06 Roussel Uclaf NOVEL FLUORINATED OR HYDROXYLATED PHENYLIMIDAZOLIDINES, METHOD, PREPARATION MEDIA, APPLICATION AS MEDICAMENTS, NEW USE AND PHARMACEUTICAL COMPOSITIONS
FR2742749B1 (en) 1995-12-22 1998-02-06 Roussel Uclaf NOVEL PHENYLIMIDAZOLIDINES INCLUDING IN PARTICULAR A NITROOXY OR CARBONYLOXY RADICAL, PROCESS AND INTERMEDIATES FOR PREPARATION, APPLICATION AS MEDICAMENTS, NEW USES AND PHARMACEUTICAL COMPOSITIONS
AU755165B2 (en) * 1998-10-23 2002-12-05 Aventis Pharma S.A. Preparations for topical application of substances having antiandrogenic effect
JP4621335B2 (en) 2000-06-28 2011-01-26 セイコーエプソン株式会社 Printer unit for information terminals
AU2002360932A1 (en) * 2001-11-23 2003-06-10 Schering Aktiengesellschaft Piperazine derivatives destabilising androgen receptors
US6861432B2 (en) 2001-11-23 2005-03-01 Schering Aktiengesellschaft Piperazine derivatives that destabilize androgen receptors
DE10218963A1 (en) * 2002-04-27 2003-11-20 Aventis Pharma Gmbh Preparations for the topical application of antiandrogen active substances
FR2845383B1 (en) * 2002-10-04 2004-12-31 Fournier Lab Sa COMPOUNDS DERIVED FROM 2-THIOHYDANTOIN AND THEIR USE IN THERAPEUTICS
AU2003279442A1 (en) * 2002-10-04 2004-04-23 Laboratoires Fournier S.A. 2-thiohydantoine derivative compounds and use thereof for the treatment of diabetes
DE10322108B4 (en) * 2003-05-09 2008-12-11 Bayer Schering Pharma Aktiengesellschaft Antiandrogenic pyrrolidines with antitumor activity
US7271188B2 (en) 2003-06-12 2007-09-18 Chugai Seikayu Kabushiki Kaisha Imidazolidine derivatives
NZ548209A (en) 2003-12-19 2009-07-31 Univ California Methods and materials for assessing prostate cancer thearapies
WO2005099693A2 (en) 2004-02-24 2005-10-27 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
EP1621535A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1775289B1 (en) * 2004-08-03 2011-03-30 Chugai Seiyaku Kabushiki Kaisha Novel imidazolidine derivatives
KR20070106969A (en) * 2004-09-09 2007-11-06 추가이 세이야쿠 가부시키가이샤 Novel imidazolidine derivative and use thereof
KR20230003445A (en) * 2005-05-13 2023-01-05 더 리전트 오브 더 유니버시티 오브 캘리포니아 Diarylhydantoin compounds
AU2013203255C1 (en) * 2005-05-13 2017-01-19 The Regents Of The University Of California Diarylthiohydantoin compounds
DK1891038T3 (en) * 2005-05-13 2009-01-19 Lilly Co Eli Substituted n-arylpyrrolidines as selective androgen receptor modulators
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
US7709516B2 (en) * 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
CN101032483B (en) * 2006-03-09 2011-05-04 陈德桂 Hydantoin derivative for adjusting estrogen receptor activity and application thereof
EP2368550B1 (en) 2006-03-27 2013-09-04 The Regents of the University of California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
SG170809A1 (en) * 2006-03-29 2011-05-30 Univ California Diarylthiohydantoin compounds
US9284345B2 (en) 2007-04-12 2016-03-15 Endorecherche, Inc. 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators
TW201716385A (en) 2007-10-26 2017-05-16 加州大學董事會 Diarylhydantoin compounds
WO2009097996A1 (en) * 2008-02-07 2009-08-13 Sanofi-Aventis Use of substituted phenylimidazolidines for producing medicaments for treating metabolic syndrome
WO2009097997A1 (en) * 2008-02-07 2009-08-13 Sanofi-Aventis Substituted imidazolidine-2,4-diones, method for the production thereof, medicaments containing said compounds and use thereof
US8067448B2 (en) 2008-02-22 2011-11-29 Radius Health, Inc. Selective androgen receptor modulators
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
WO2009145286A1 (en) 2008-05-30 2009-12-03 武田薬品工業株式会社 Heterocyclic compound
WO2010069519A1 (en) 2008-12-18 2010-06-24 Merz Pharma Gmbh & Co. Kgaa Topical compositions comprising at least one active ingredient poorly soluble in water and biopolymers such as hyaluronic acid with a pka-value between 5-7
WO2010092371A1 (en) 2009-02-10 2010-08-19 Astrazeneca Ab Triazolo [4,3-b] pyridazine derivatives and their uses for prostate cancer
FR2944524B1 (en) * 2009-04-17 2012-11-30 Ipsen Pharma Sas IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AND THEIR USE AS A MEDICINAL PRODUCT
TW201111378A (en) 2009-09-11 2011-04-01 Bayer Schering Pharma Ag Substituted (heteroarylmethyl) thiohydantoins
FR2954317B1 (en) 2009-12-23 2012-01-27 Galderma Res & Dev NOVEL PHENOLIC DERIVATIVES, AND THEIR PHARMACEUTICAL OR COSMETIC USE
FR2954315B1 (en) 2009-12-23 2012-02-24 Galderma Res & Dev NOVEL PHENOLIC DERIVATIVES, AND THEIR PHARMACEUTICAL OR COSMETIC USE
FR2954316B1 (en) 2009-12-23 2014-01-03 Galderma Res & Dev NOVEL PHENOLIC DERIVATIVES, AND THEIR PHARMACEUTICAL OR COSMETIC USE
WO2011097496A1 (en) 2010-02-04 2011-08-11 Radius Health, Inc. Selective androgen receptor modulators
EP2536708A4 (en) 2010-02-16 2013-05-29 Aragon Pharmaceuticals Inc Androgen receptor modulators and uses thereof
JP5718372B2 (en) * 2010-02-24 2015-05-13 メディベイション プロステイト セラピューティクス， インコーポレイテッド Process for the synthesis of diarylthiohydantoin compounds and diarylhydantoin compounds
PT2568806T (en) 2010-05-12 2016-08-05 Radius Health Inc Therapeutic regimens
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
EP2621901B1 (en) 2010-09-28 2015-07-29 Radius Health, Inc Selective androgen receptor modulators
CN104661658A (en) 2012-09-26 2015-05-27 阿拉贡药品公司 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
JOP20200097A1 (en) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc Androgen receptor modulator and uses thereof
US9682960B2 (en) 2013-12-19 2017-06-20 Endorecherche, Inc. Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
US10420734B2 (en) 2014-03-28 2019-09-24 Duke University Method of treating cancer using selective estrogen receptor modulators
CN103965112A (en) * 2014-05-13 2014-08-06 上海孚一生物科技有限公司 Compound with antiandrogen activity as well as preparation method and application of compound
TWI726969B (en) 2016-01-11 2021-05-11 比利時商健生藥品公司 Substituted thiohydantoin derivatives as androgen receptor antagonists
PL3474841T3 (en) 2016-06-22 2022-07-11 Ellipses Pharma Ltd Ar+ breast cancer treatment methods
JP2020514291A (en) 2017-01-05 2020-05-21 ラジウス ファーマシューティカルズ，インコーポレイテッド Polymorphic forms of RAD1901-2HCL
CN111479560A (en) 2017-10-16 2020-07-31 阿拉贡药品公司 Antiandrogen for treating non-metastatic castration-resistant prostate cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4916937B1 (en) * 1970-01-21 1974-04-25
US3823240A (en) * 1970-10-06 1974-07-09 Rhone Poulenc Sa Fungicidal hydantoin derivatives
US3923994A (en) * 1973-07-13 1975-12-02 Smithkline Corp Anti-arthritic compositions comprising a 3-aryl 2-thiohydantoin and methods of producing anti-arthritic acitvity
FR2329276A1 (en) * 1975-10-29 1977-05-27 Roussel Uclaf NEW SUBSTITUTES IMIDAZOLIDINES, METHOD OF PREPARATION, APPLICATION AS A MEDICINAL PRODUCT AND COMPOSITIONS CONTAINING THEM
MC1220A1 (en) * 1977-10-28 1979-07-20 Hoffmann La Roche NEW DERIVATIVES OF IMIDAZOLIDINE
DE2933917A1 (en) * 1979-08-22 1981-03-26 Basf Ag, 67063 Ludwigshafen 5-IMINO-IMIDAZOLIDIN-2-ONE AND HERBICIDES CONTAINING THEM.
US4753957A (en) * 1981-09-28 1988-06-28 Rohm And Haas Company Substituted 2,4-imidazolidinediones and fungicidal compositions
EP0091596B1 (en) * 1982-04-08 1991-09-11 Shell Internationale Researchmaatschappij B.V. Hydantoins, their preparation and application
US4473393A (en) * 1982-08-06 1984-09-25 Buffalo Color Corporation Pesticidal thiohydantoin compositions
FR2656302B1 (en) * 1989-12-22 1992-05-07 Roussel Uclaf NEW PROCESS FOR THE PREPARATION OF ANANDRON AND ANANDRON DERIVATIVES.
FR2671348B1 (en) * 1991-01-09 1993-03-26 Roussel Uclaf NOVEL PHENYLIMIDAZOLIDINES, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Also Published As

Publication number Publication date
EP0580459B1 (en) 2001-03-28
EP0580459A1 (en) 1994-01-26
UA34428C2 (en) 2001-03-15
CN1044234C (en) 1999-07-21
RU2116298C1 (en) 1998-07-27
FR2693461B1 (en) 1994-09-02
AU3987693A (en) 1994-01-13
KR100294383B1 (en) 2001-09-17
CA2097248A1 (en) 1994-01-09
JP3845455B2 (en) 2006-11-15
JPH0673017A (en) 1994-03-15
AU670942B2 (en) 1996-08-08
FR2693461A1 (en) 1994-01-14
PT580459E (en) 2001-07-31
GR3035768T3 (en) 2001-07-31
HUT64527A (en) 1994-01-28
ES2155067T3 (en) 2001-05-01
KR940005582A (en) 1994-03-21
CN1081182A (en) 1994-01-26
ATE200077T1 (en) 2001-04-15
HU9301585D0 (en) 1993-09-28
ZA933786B (en) 1994-05-30
DE69330058D1 (en) 2001-05-03
DE69330058T2 (en) 2001-09-06

Similar Documents

Publication Publication Date Title
DK0580459T3 (en) Substituted phenylimidazolidines, their use as pharmaceuticals and pharmaceuticals containing them
DK0494819T3 (en) New phenylimidazolidines, their preparation, use as pharmaceuticals and pharmaceutical compositions containing them
AP1468A (en) Hiv inhibiting pyrimidine derivatives.
HUP0003731A2 (en) 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as mek inhibitors
AP1475A (en) Trisubstituted 1, 3, 5-triazine derivatives for treatment of HIV infections.
NO934719L (en) Inhibitors of HIV protease useful for the treatment of AIDS
DK1163212T3 (en) amide derivatives
FI913478A0 (en) DIAZINDERIVAT.
ATE233754T1 (en) DIPHENYL-PIPERIDINE DERIVATIVES
DE69431316D1 (en) Amide derivatives and their therapeutic use
HUP0400464A2 (en) Adenosine analogues for treatment of the insulin resistance syndrome and diabetes
DK0604186T3 (en) HIV protease inhibitors suitable for the treatment of AIDS
ATE500231T1 (en) HIV-INHIBITING PYRIMIDINE DERIVATIVES
KR950002761A (en) Use of N- (pyridinyl) -1H-indol-1-amine as a therapeutic agent for obsessive compulsive disorder
EA200100534A1 (en) DERIVATIVES OF 2,4-DISABILED TRIAZINE
BR9712763A (en) Benzene sulfonamide derivatives and drugs containing such derivatives
EP0785193A4 (en) Arylthiadiazole derivative and antiviral agent containing the same
NO20000114D0 (en) 2,4,4-trisubstituted-1,3-diocholane antifungal agents
TR200100906T2 (en) Benzamide derivatives as thrombin inhibitors
ES2135383T3 (en) PIRIDO (3,4-B) PIRROLLO (1,2-E) (1,4,5) OXADIAZEPINES AND RELATED ANALOG COMPOUNDS, A PROCEDURE FOR THEIR PREPARATION AND USE AS MEDICINES.
TH3325EX (en) Phenylbenzoylurea
TH4707EX (en) Phenylbenzoylurea
TH65065A (en) Chemical compound