DK0557876T3 - Use of xanthine derivatives for the treatment of muscle damage after complete interruption of blood circulation - Google Patents
Use of xanthine derivatives for the treatment of muscle damage after complete interruption of blood circulationInfo
- Publication number
- DK0557876T3 DK0557876T3 DK93102450.9T DK93102450T DK0557876T3 DK 0557876 T3 DK0557876 T3 DK 0557876T3 DK 93102450 T DK93102450 T DK 93102450T DK 0557876 T3 DK0557876 T3 DK 0557876T3
- Authority
- DK
- Denmark
- Prior art keywords
- atoms
- treatment
- blood circulation
- radical
- muscle damage
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Xanthine derivatives of the formula I <IMAGE> where at least one of the radicals R<1> and R<3> is a radical of the formula Ia <IMAGE> R<4> is a (C1-C3)-alkyl radical, n is an integer from 2 to 5 and, if only one of the radicals R<1> and R<3> is such a tertiary hydroxyalkyl group of the formula Ia, the other radical is a hydrogen atom or an aliphatic hydrocarbon radical R<5> which has up to 6 C atoms and whose carbon chain can be interrupted by up to 2 oxygen atoms or be substituted by an oxo group or up to two hydroxyl groups, these oxo and hydroxyl groups being separated from the ring nitrogen by at least 2 C atoms, and R<2> is an alkyl group with 1-4 C atoms, are suitable for the preparation of pharmaceutical compositions for the prophylaxis and treatment of muscle damage which may occur after interruption of the blood circulation.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4205424 | 1992-02-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0557876T3 true DK0557876T3 (en) | 1997-05-26 |
Family
ID=6452327
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93102450.9T DK0557876T3 (en) | 1992-02-22 | 1993-02-17 | Use of xanthine derivatives for the treatment of muscle damage after complete interruption of blood circulation |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0557876B1 (en) |
JP (1) | JP3193800B2 (en) |
KR (1) | KR930017580A (en) |
AT (1) | ATE146078T1 (en) |
AU (1) | AU658979B2 (en) |
CA (1) | CA2089959A1 (en) |
DE (1) | DE59304710D1 (en) |
DK (1) | DK0557876T3 (en) |
ES (1) | ES2096115T3 (en) |
GR (1) | GR3022183T3 (en) |
HU (1) | HUT64472A (en) |
TW (1) | TW288977B (en) |
ZA (1) | ZA931184B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3792266B2 (en) * | 1994-06-16 | 2006-07-05 | 森精機興産株式会社 | Method and apparatus for correcting thermal displacement of machine tool |
DE19540798A1 (en) * | 1995-11-02 | 1997-05-07 | Hoechst Ag | Alkylxanthine phosphonates and alkylxanthine phosphine oxides and their use as medicines |
US5856330A (en) * | 1996-07-31 | 1999-01-05 | Hoechst Aktiengesellschaft | Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin |
US5981536A (en) * | 1996-07-31 | 1999-11-09 | Hoechst Aktiengesellschaft | Use of xanthine derivatives for the modulation of apoptosis |
WO2007041506A1 (en) * | 2005-10-03 | 2007-04-12 | Melior Discovery, Inc. | Purine formulations and methods for managing disorders |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH608236A5 (en) * | 1974-01-22 | 1978-12-29 | Wuelfing J A Fa | |
DE3525801A1 (en) * | 1985-07-19 | 1987-01-22 | Hoechst Ag | TERTIA HYDROXYALKYLXANTHINE, METHOD FOR THE PRODUCTION THEREOF, THE MEDICINAL PRODUCT CONTAINING IT AND THEIR USE |
GB8621870D0 (en) * | 1986-09-11 | 1986-10-15 | Beecham Group Plc | Active compounds |
ES2087205T3 (en) * | 1990-11-07 | 1996-07-16 | Hoechst Roussel Pharma | USE OF XANTHINES FOR THE PREPARATION OF AN EFFECTIVE MEDICATION TO INHIBIT THE REPLICATION OF HUMAN RETROVIRUSES. |
-
1993
- 1993-02-17 ES ES93102450T patent/ES2096115T3/en not_active Expired - Lifetime
- 1993-02-17 TW TW082101087A patent/TW288977B/zh active
- 1993-02-17 AT AT93102450T patent/ATE146078T1/en not_active IP Right Cessation
- 1993-02-17 EP EP93102450A patent/EP0557876B1/en not_active Expired - Lifetime
- 1993-02-17 DK DK93102450.9T patent/DK0557876T3/en active
- 1993-02-17 DE DE59304710T patent/DE59304710D1/en not_active Expired - Lifetime
- 1993-02-19 ZA ZA931184A patent/ZA931184B/en unknown
- 1993-02-19 JP JP02951693A patent/JP3193800B2/en not_active Expired - Lifetime
- 1993-02-19 AU AU33761/93A patent/AU658979B2/en not_active Ceased
- 1993-02-19 CA CA002089959A patent/CA2089959A1/en not_active Abandoned
- 1993-02-22 HU HU9300476A patent/HUT64472A/en unknown
- 1993-02-22 KR KR1019930002426A patent/KR930017580A/en not_active Application Discontinuation
-
1996
- 1996-12-30 GR GR960403651T patent/GR3022183T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW288977B (en) | 1996-10-21 |
KR930017580A (en) | 1993-09-20 |
ATE146078T1 (en) | 1996-12-15 |
AU3376193A (en) | 1993-08-26 |
GR3022183T3 (en) | 1997-03-31 |
HUT64472A (en) | 1994-01-28 |
CA2089959A1 (en) | 1993-08-23 |
JP3193800B2 (en) | 2001-07-30 |
ES2096115T3 (en) | 1997-03-01 |
EP0557876A1 (en) | 1993-09-01 |
JPH069634A (en) | 1994-01-18 |
HU9300476D0 (en) | 1993-05-28 |
EP0557876B1 (en) | 1996-12-11 |
ZA931184B (en) | 1993-09-16 |
DE59304710D1 (en) | 1997-01-23 |
AU658979B2 (en) | 1995-05-04 |
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