DK0520883T3 - Derivatives of 2-aminopyrimidine-4-carboxamide, their preparation and their therapeutic use - Google Patents

Derivatives of 2-aminopyrimidine-4-carboxamide, their preparation and their therapeutic use

Info

Publication number
DK0520883T3
DK0520883T3 DK92401773.4T DK92401773T DK0520883T3 DK 0520883 T3 DK0520883 T3 DK 0520883T3 DK 92401773 T DK92401773 T DK 92401773T DK 0520883 T3 DK0520883 T3 DK 0520883T3
Authority
DK
Denmark
Prior art keywords
aminopyrimidine
carboxamide
derivatives
preparation
ethyl
Prior art date
Application number
DK92401773.4T
Other languages
Danish (da)
Inventor
Pascal George
Philippe Manoury
Benoit Marabout
Jacques Froissant
Jean-Pierre Merly
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Application granted granted Critical
Publication of DK0520883T3 publication Critical patent/DK0520883T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Compounds corresponding to the general formula (I) <IMAGE> (I) in which n=2 or 3, X=H, F, Cl or OCH3, R=H or CH3, R1=H or CH3, R2=alkyl, hydroxyalkyl, (hydroxy)(methoxy)alkyl, dimethoxyalkyl, 2-(aminosulphonyl)ethyl, 2-(methylsulphonyl)ethyl, 2-(methylsulphonylamino)ethyl, aminocarbonylmethyl which is optionally substituted by nitrogen, phenylethyl which is optionally substituted, pyrimidinylaminoalkyl or arylcaronylaminoalkyl, or else R1 and R2 form, with the nitrogen which carries them, a piperidine, morpholine, thiomorpholine or piperazine ring, optionally substituted by nitrogen. Use in therapeutics.
DK92401773.4T 1991-06-27 1992-06-24 Derivatives of 2-aminopyrimidine-4-carboxamide, their preparation and their therapeutic use DK0520883T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9107939A FR2678272B1 (en) 1991-06-27 1991-06-27 2-AMINOPYRIMIDINE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.

Publications (1)

Publication Number Publication Date
DK0520883T3 true DK0520883T3 (en) 1995-12-11

Family

ID=9414359

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92401773.4T DK0520883T3 (en) 1991-06-27 1992-06-24 Derivatives of 2-aminopyrimidine-4-carboxamide, their preparation and their therapeutic use

Country Status (23)

Country Link
US (1) US5244894A (en)
EP (1) EP0520883B1 (en)
JP (1) JP3159526B2 (en)
KR (1) KR930000508A (en)
CN (1) CN1067885A (en)
AT (1) ATE124935T1 (en)
AU (1) AU644295B2 (en)
CA (1) CA2072433A1 (en)
CZ (1) CZ9202003A3 (en)
DE (1) DE69203402T2 (en)
DK (1) DK0520883T3 (en)
ES (1) ES2077998T3 (en)
FI (1) FI922982A (en)
FR (1) FR2678272B1 (en)
GR (1) GR3017249T3 (en)
HU (1) HUT61749A (en)
IE (1) IE922094A1 (en)
IL (1) IL102332A0 (en)
MX (1) MX9203333A (en)
NO (1) NO922525L (en)
NZ (1) NZ243340A (en)
PL (1) PL295045A1 (en)
ZA (1) ZA924785B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0598046T3 (en) * 1991-08-14 1999-05-25 Procter & Gamble Pharma New ureas suitable as antiarrhythmic and anti-fibrillating agents
ATE123025T1 (en) * 1992-07-03 1995-06-15 Synthelabo 2-AMINO-N-(((4-(AMINOCARBONYL)PYRIMIDINE-2- YL>AMINO>ALKYL>-PYRIMIDINE-4- CARBOXYLIC AMIDE DERIVATIVES, THEIR PRODUCTION AND THEIR APPLICATION IN THERAPEUTICS.
FR2703355B1 (en) * 1993-03-29 1995-05-05 Synthelabo 2-Aminopyrimidine-4-carboxamide derivatives, their preparation and their therapeutic use.
DE4425143A1 (en) * 1994-07-15 1996-01-18 Basf Ag Substituted pyrimidine compounds and their use
US5688795A (en) * 1994-11-08 1997-11-18 Syntex (U.S.A.) Inc. 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists
FR2744722B1 (en) * 1996-02-14 1998-03-13 Synthelabo DEVIRES DE 2 - ((3- (PIPERAZIN-1-YL) PROPYL) AMINO) PYRIMIDINE-4- CARBOXAMIDE AND THEIR THERAPEUTIC APPLICATION
CA2327543A1 (en) 1998-05-06 1999-11-11 Duke University Method of treating bladder and lower urinary tract syndromes
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
US20060009491A1 (en) * 2004-06-24 2006-01-12 Incyte Corporation Amido compounds and their use as pharmaceuticals
CA2584502A1 (en) * 2004-06-24 2006-01-05 Incyte Corporation 2-methylpropanamides and their use as pharmaceuticals
EP1758580A4 (en) 2004-06-24 2008-01-16 Incyte Corp N-substituted piperidines and their use as pharmaceuticals
EA200700118A1 (en) * 2004-06-24 2007-08-31 Инсайт Корпорейшн AMIDOCIOUSNESS AND THEIR APPLICATION AS MEDICINES
US20060122197A1 (en) * 2004-08-10 2006-06-08 Wenqing Yao Amido compounds and their use as pharmaceuticals
AU2013259551B2 (en) * 2012-05-09 2017-11-02 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2143730A1 (en) * 1971-09-01 1973-03-08 Byk Gulden Lomberg Chem Fab Substd pyridines prepn - hypotensives, analgesics and inters
FR2656609B1 (en) * 1989-12-28 1992-03-27 Synthelabo 2-AMINOPYRIMIDINE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.
FR2678271B1 (en) * 1991-06-27 1995-01-13 Synthelabo PYRIMIDINE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.

Also Published As

Publication number Publication date
DE69203402T2 (en) 1996-03-07
FI922982A0 (en) 1992-06-26
FR2678272A1 (en) 1992-12-31
PL295045A1 (en) 1993-03-08
FR2678272B1 (en) 1994-01-14
NZ243340A (en) 1994-02-25
HUT61749A (en) 1993-03-01
KR930000508A (en) 1993-01-15
US5244894A (en) 1993-09-14
CN1067885A (en) 1993-01-13
CA2072433A1 (en) 1992-12-28
MX9203333A (en) 1993-02-01
DE69203402D1 (en) 1995-08-17
HU9202143D0 (en) 1992-10-28
NO922525D0 (en) 1992-06-26
EP0520883B1 (en) 1995-07-12
AU1858892A (en) 1993-01-07
FI922982A (en) 1992-12-28
IL102332A0 (en) 1993-01-14
JP3159526B2 (en) 2001-04-23
AU644295B2 (en) 1993-12-02
EP0520883A1 (en) 1992-12-30
ATE124935T1 (en) 1995-07-15
IE922094A1 (en) 1992-12-30
NO922525L (en) 1992-12-28
CZ9202003A3 (en) 1993-01-13
ES2077998T3 (en) 1995-12-01
GR3017249T3 (en) 1995-11-30
JPH05186435A (en) 1993-07-27
ZA924785B (en) 1993-03-31

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