DK0506769T3 - Pharmaceutical composition for treating or preventing retroviral infections - Google Patents

Pharmaceutical composition for treating or preventing retroviral infections

Info

Publication number
DK0506769T3
DK0506769T3 DK91901458.9T DK91901458T DK0506769T3 DK 0506769 T3 DK0506769 T3 DK 0506769T3 DK 91901458 T DK91901458 T DK 91901458T DK 0506769 T3 DK0506769 T3 DK 0506769T3
Authority
DK
Denmark
Prior art keywords
treating
pharmaceutical composition
retroviral infections
preventing retroviral
arg
Prior art date
Application number
DK91901458.9T
Other languages
Danish (da)
Inventor
Bruno Guy
Jean-Pierre Lecocq
Original Assignee
Transgene Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9013102A external-priority patent/FR2668065B1/en
Application filed by Transgene Sa filed Critical Transgene Sa
Application granted granted Critical
Publication of DK0506769T3 publication Critical patent/DK0506769T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A pharmaceutical composition for treating or preventing retroviral diseases containing a thiol-protease inhibitor as an active principle. Thiol-protease inhibitors are known products such as cystatines and the derivatives thereof, antipaine [(S)-1-carboxy-2-phenyletyl]-carbamoyl-Arg-Val-Arg-al, E-64 (L-trans-epoxysuccinyl-leucylamide-(4-guanidino)-butane, N-[N-(L-3-transcarboxyirane-2-carbonyl)-L-leucyl]-agmatine, leupeptin, iodoacetic acid/iodoacetamide or N-Cbz-Phe-Ala-diazomethane.
DK91901458.9T 1989-12-18 1990-12-18 Pharmaceutical composition for treating or preventing retroviral infections DK0506769T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8916726 1989-12-18
FR9013102A FR2668065B1 (en) 1990-10-23 1990-10-23 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND PREVENTION OF RETROVIRAL INFECTIONS.

Publications (1)

Publication Number Publication Date
DK0506769T3 true DK0506769T3 (en) 1994-11-28

Family

ID=26227737

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91901458.9T DK0506769T3 (en) 1989-12-18 1990-12-18 Pharmaceutical composition for treating or preventing retroviral infections

Country Status (8)

Country Link
EP (1) EP0506769B1 (en)
JP (1) JPH05502868A (en)
AT (1) ATE109006T1 (en)
AU (2) AU644621B2 (en)
CA (1) CA2071972A1 (en)
DE (1) DE69011130T2 (en)
DK (1) DK0506769T3 (en)
WO (1) WO1991008769A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3604093A (en) * 1992-02-07 1993-09-03 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Use of 5,5'-dithio-bis(2-nitrobenzoic acid) for inhibition of HIV protease
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
ATE253050T1 (en) 1992-03-11 2003-11-15 Narhex Ltd AMINE DERIVATIVES OF OXO- AND HYDROXY-SUBSTITUTED HYDROCARBONS
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
EP0633881B1 (en) * 1992-03-11 2003-10-29 Narhex Limited Amine derivatives of oxo- and hydroxy-substitued hydrocarbons
JP3517238B2 (en) * 1992-09-09 2004-04-12 アムジェン インコーポレイテッド Inhibition of retroviral infection
FR2778851B1 (en) * 1998-05-19 2002-07-26 Aetsrn COMPOSITION BASED ON CYSTEINE PROTEASE INHIBITORS FOR DELAYING SENESCENCE, SELF-DESTRUCTION AND HEMOLYSIS OF ERYTHROCYTES
WO2005011649A2 (en) * 2003-05-19 2005-02-10 Vanderbilt University Methods of treating severe acute respiratory syndrome virus infections
US8232240B2 (en) 2005-02-23 2012-07-31 The Brigham And Women's Hospital, Inc. Inhibitors of enveloped virus infectivity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8510058A8 (en) * 1985-01-16 1996-04-30 Inst Jozef Stefan P O Process for insulation of poultry egg's cystatine from egg-white
EP0269311A3 (en) * 1986-11-17 1990-06-06 Merck & Co. Inc. Methods of treating bone diseases by administration of a cysteine proteinase inhibitor

Also Published As

Publication number Publication date
AU6975591A (en) 1991-07-18
CA2071972A1 (en) 1991-06-19
DE69011130D1 (en) 1994-09-01
DE69011130T2 (en) 1995-03-16
AU644621B2 (en) 1993-12-16
WO1991008769A1 (en) 1991-06-27
ATE109006T1 (en) 1994-08-15
JPH05502868A (en) 1993-05-20
EP0506769A1 (en) 1992-10-07
EP0506769B1 (en) 1994-07-27

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