DK0502020T3 - New benzo (b) -1,7-phenanthroline derivatives, their preparation and their therapeutic use - Google Patents

New benzo (b) -1,7-phenanthroline derivatives, their preparation and their therapeutic use

Info

Publication number
DK0502020T3
DK0502020T3 DK90917107.6T DK90917107T DK0502020T3 DK 0502020 T3 DK0502020 T3 DK 0502020T3 DK 90917107 T DK90917107 T DK 90917107T DK 0502020 T3 DK0502020 T3 DK 0502020T3
Authority
DK
Denmark
Prior art keywords
radical
preparation
therapeutic use
alkyl group
phenanthroline derivatives
Prior art date
Application number
DK90917107.6T
Other languages
Danish (da)
Inventor
Dennis Bigg
Jean Lhomme
Herve Salez
A Wardani
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Application granted granted Critical
Publication of DK0502020T3 publication Critical patent/DK0502020T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel benzo [b] phenathroline derivatives of general formula (I), wherein A represents a nitrogen atom or a Me-N?+ radical; R1? represents, independently from R2?, a formyl radical (CHO), a radical of the formula -CH2?OR3?, wherein R3? is a hydrogen atom or a C1-4? alkyl group; R2? represents, independently from R1?, a hydroxyl radical, a radical of the formula -NHR4?, wherein R4? is a hydrogen atom or a C1-4? alkyl group; or R1? and R2? together represent: a -CH2?OH2?N(R4?)- radical, wherein R4? is a hydrogen atom or a C1-4? alkyl group, a -CH2?OCH2?O- radical; and the therapeutically acceptable mineral or organic salts thereof.
DK90917107.6T 1989-11-14 1990-11-14 New benzo (b) -1,7-phenanthroline derivatives, their preparation and their therapeutic use DK0502020T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR898914900A FR2654340B1 (en) 1989-11-14 1989-11-14 NOVEL BENZO [B] PHENANTHROLINES-1,7 DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC APPLICATION.

Publications (1)

Publication Number Publication Date
DK0502020T3 true DK0502020T3 (en) 1994-05-09

Family

ID=9387369

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90917107.6T DK0502020T3 (en) 1989-11-14 1990-11-14 New benzo (b) -1,7-phenanthroline derivatives, their preparation and their therapeutic use

Country Status (8)

Country Link
EP (1) EP0502020B1 (en)
JP (1) JPH05501562A (en)
AT (1) ATE100809T1 (en)
DE (1) DE69006366T2 (en)
DK (1) DK0502020T3 (en)
ES (1) ES2062568T3 (en)
FR (1) FR2654340B1 (en)
WO (1) WO1991007403A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9027111D0 (en) * 1990-12-13 1991-02-06 Raychem Ltd Circuit protection device
FR2712290A1 (en) * 1993-11-10 1995-05-19 Pf Medicament New oxazino-acridine derivs.
GB9517506D0 (en) * 1994-12-16 1995-10-25 Univ Cardiff Benzophenanthrolines
DE102012006903B4 (en) * 2012-04-05 2016-06-30 Christian-Albrechts-Universität Zu Kiel Novel aromatic heterocycles, process for their preparation and medicaments containing novel aromatic heterocycles
CN111154481B (en) * 2020-01-06 2023-03-28 山东理工大学 Preparation method of nano fluorescent probe for detecting deubiquitinase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199887A (en) * 1982-03-02 1985-03-20 New Zealand Dev Finance Phenanthroline derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
ATE100809T1 (en) 1994-02-15
FR2654340B1 (en) 1994-03-04
JPH05501562A (en) 1993-03-25
WO1991007403A1 (en) 1991-05-30
EP0502020A1 (en) 1992-09-09
ES2062568T3 (en) 1994-12-16
DE69006366T2 (en) 1994-08-11
FR2654340A1 (en) 1991-05-17
DE69006366D1 (en) 1994-03-10
EP0502020B1 (en) 1994-01-26

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