DK0398024T3 - Tumor localization and / or tumor therapy conjugates - Google Patents
Tumor localization and / or tumor therapy conjugatesInfo
- Publication number
- DK0398024T3 DK0398024T3 DK90107187.8T DK90107187T DK0398024T3 DK 0398024 T3 DK0398024 T3 DK 0398024T3 DK 90107187 T DK90107187 T DK 90107187T DK 0398024 T3 DK0398024 T3 DK 0398024T3
- Authority
- DK
- Denmark
- Prior art keywords
- polyalcohol
- tumor
- derivatised
- protein
- conjugates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The invention relates to conjugates consisting of a) at least one polyalcohol or a derivatised polyalcohol, b) at least one active agent, c) at least one linker and d) a protein, characterised in that the polyalcohol(s) or the derivatised polyalcohol(s) are polyalcohols or derivatised polyalcohols which are not recognised as foreign by the defence system of an organism, and the protein is a protein which is not recognised as foreign by the defence system of an organism and can be taken up specifically or non-specifically by the tumour. These conjugates are suitable, on the one hand, for making possible a very sensitive nuclear medical diagnosis of tumours and, on the other hand, for example for making available new tumour diagnosis methods in X-ray diagnosis, computed tomography, MR imaging, electron spin resonance spectroscopy or electron microscopy. <IMAGE>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3912792A DE3912792A1 (en) | 1989-04-19 | 1989-04-19 | CONJUGATES FOR TUMOR LOCALIZATION AND / OR TUMOR THERAPY, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING DIAGNOSTICS AND / OR THERAPEUTICS |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0398024T3 true DK0398024T3 (en) | 1993-03-29 |
Family
ID=6378961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90107187.8T DK0398024T3 (en) | 1989-04-19 | 1990-03-14 | Tumor localization and / or tumor therapy conjugates |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0398024B1 (en) |
JP (1) | JPH0819156B2 (en) |
AT (1) | ATE85894T1 (en) |
DE (2) | DE3912792A1 (en) |
DK (1) | DK0398024T3 (en) |
ES (1) | ES2054137T3 (en) |
GR (1) | GR3007136T3 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4334317A1 (en) * | 1993-10-08 | 1995-04-13 | Dombaj Gmbh | Apparatus for separating liquid streams containing dissociated substances |
DE4435087A1 (en) * | 1994-09-30 | 1996-04-04 | Deutsches Krebsforsch | Conjugate for the treatment of infectious, autoimmune and skin diseases |
GB0609370D0 (en) * | 2006-05-11 | 2006-06-21 | Mock Graham A | Process for cross-linking macromolecules |
JP2010054305A (en) * | 2008-08-27 | 2010-03-11 | Tohoku Denshi Sangyo Kk | Method for acquiring data used for cancer contraction verification |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4466951A (en) * | 1982-11-12 | 1984-08-21 | University Of California | Intracellular trapping of therapeutics or tracer agents |
-
1989
- 1989-04-19 DE DE3912792A patent/DE3912792A1/en not_active Withdrawn
-
1990
- 1990-03-14 DE DE9090107187T patent/DE59000908D1/en not_active Expired - Fee Related
- 1990-03-14 DK DK90107187.8T patent/DK0398024T3/en active
- 1990-03-14 AT AT90107187T patent/ATE85894T1/en not_active IP Right Cessation
- 1990-03-14 ES ES90107187T patent/ES2054137T3/en not_active Expired - Lifetime
- 1990-03-14 EP EP90107187A patent/EP0398024B1/en not_active Expired - Lifetime
- 1990-04-18 JP JP2100546A patent/JPH0819156B2/en not_active Expired - Fee Related
-
1993
- 1993-02-25 GR GR920403127T patent/GR3007136T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE59000908D1 (en) | 1993-04-01 |
EP0398024A1 (en) | 1990-11-22 |
DE3912792A1 (en) | 1990-10-25 |
JPH0334999A (en) | 1991-02-14 |
ES2054137T3 (en) | 1994-08-01 |
GR3007136T3 (en) | 1993-07-30 |
ATE85894T1 (en) | 1993-03-15 |
JPH0819156B2 (en) | 1996-02-28 |
EP0398024B1 (en) | 1993-02-24 |
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