DE879006C - Process for the production of a blood-coagulant substance from the lungs - Google Patents

Process for the production of a blood-coagulant substance from the lungs

Info

Publication number
DE879006C
DE879006C DEF4023D DEF0004023D DE879006C DE 879006 C DE879006 C DE 879006C DE F4023 D DEF4023 D DE F4023D DE F0004023 D DEF0004023 D DE F0004023D DE 879006 C DE879006 C DE 879006C
Authority
DE
Germany
Prior art keywords
blood
lungs
production
neutrally
frozen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEF4023D
Other languages
German (de)
Inventor
Willy Dr Ludwig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DEF4023D priority Critical patent/DE879006C/en
Application granted granted Critical
Publication of DE879006C publication Critical patent/DE879006C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells

Description

Verfahren zur Herstellung einer blutgerinnungsfördernden Substanz aus Lunge In weiterer Ausarbeitung des Verfahrens des Patents 874061 wurde gefunden, daß man den EYtraktionsprozeß des beschriebenen Verfahrens, nachdem das Gewebe blutfrei gewaschen wurde, neutral durchführen kann und dabei zweckmäßigerweise von gefrorener Lunge ausgeht. Process for the production of a blood coagulation-promoting substance from the lungs In a further elaboration of the process of the patent 874061 it was found that the extraction process of the process described can be carried out neutrally after the tissue has been washed blood-free and expediently proceeded from frozen lungs.

Beispiel i kg etwa 8 Tage im Kühlraum gefroren gelagerte Rinderlunge wird in der Fleischmaschine zerkleinert, blutfrei gewaschen und zentrifugiert. Dann wird die gewaschene Lunge mit der gleichen Menge physiologischer Kochsalzlösung versetzt, im Kühlschrank bei Temperaturen um den Nullpunkt 48 Stunden stehengelassen, anschließend scharf zentrifugiert, die. erhaltene Lösung auf 55° erhitzt, die Temperatur lro Minuten lang gehalten. Dann wird sofort abgekühlt, .die kolloidale, trübe Lösung getrocknet. Die trockene Substanz wird wieder in Wasser aufgenommen, von unlöslichen Substanzen entfernt und die klare Lösung nach bekannten Methodenwieder aufTrockenmaterial aufgearbeitet.Example 1 kg of beef lungs stored frozen in the refrigerator for about 8 days is chopped up in the meat machine, washed blood-free and centrifuged. then the lungs are washed with the same amount of physiological saline solution mixed, left to stand in the refrigerator at temperatures around zero for 48 hours, then sharply centrifuged that. obtained solution heated to 55 °, the temperature held for lro minutes. Then it is immediately cooled, the colloidal, cloudy solution dried. The dry substance is reabsorbed in water, from insoluble Substances removed and the clear solution again by known methods processed on dry material.

Claims (1)

PATENTANSPRUCH: Elbänderung des Verfahrens nach Patent f74 o:61r zur (Gewinnung eines blutgerinnungs.-: fördernden Stoffes aus neutral und blutfrei gewaschener Lunge, dadurch gekennzeichnet, daß diese, zweckmäßig nach Lagerung in gefrorenem Zustand, bei Temperaturen urn den Gefrierpunkt neutral mehrere Tage extrahiert und der erhaltene Extrakt sofort nach der Extraktion kurze Zeit- auf etwa 5o bis 6xo° erhitzt, anschließend rasch abgekühlt, gefroren, getrocknet und nach Wiederaufnahme in Wasser und Entfernung unlöslicher Eiweißstoffe erneut nach bekannten Methoden in Trockensubstanz übergeführt wird. PATENT CLAIM: Modification of the method according to patent f74 o: 61r for (obtaining a blood coagulation: promoting substance from lungs washed neutrally and free of blood, characterized in that these, expediently after storage in the frozen state, are extracted neutrally for several days at temperatures around freezing point and the extract obtained is heated to about 5o to 6xo ° for a short time immediately after the extraction, then rapidly cooled, frozen, dried and, after being taken up again in water and insoluble proteins removed, again converted to dry matter by known methods.
DEF4023D 1942-10-27 1942-10-27 Process for the production of a blood-coagulant substance from the lungs Expired DE879006C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEF4023D DE879006C (en) 1942-10-27 1942-10-27 Process for the production of a blood-coagulant substance from the lungs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF4023D DE879006C (en) 1942-10-27 1942-10-27 Process for the production of a blood-coagulant substance from the lungs

Publications (1)

Publication Number Publication Date
DE879006C true DE879006C (en) 1953-06-08

Family

ID=7084120

Family Applications (1)

Application Number Title Priority Date Filing Date
DEF4023D Expired DE879006C (en) 1942-10-27 1942-10-27 Process for the production of a blood-coagulant substance from the lungs

Country Status (1)

Country Link
DE (1) DE879006C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE950594C (en) * 1953-07-01 1956-10-11 Upjohn Co Method for obtaining heparin

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE950594C (en) * 1953-07-01 1956-10-11 Upjohn Co Method for obtaining heparin

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