DE69924007D1 - NEUTRALIZATION ASSAY USING HUMAN PAPILOMAVIRUS SIMILAR PARTICLES - Google Patents

NEUTRALIZATION ASSAY USING HUMAN PAPILOMAVIRUS SIMILAR PARTICLES

Info

Publication number
DE69924007D1
DE69924007D1 DE69924007T DE69924007T DE69924007D1 DE 69924007 D1 DE69924007 D1 DE 69924007D1 DE 69924007 T DE69924007 T DE 69924007T DE 69924007 T DE69924007 T DE 69924007T DE 69924007 D1 DE69924007 D1 DE 69924007D1
Authority
DE
Germany
Prior art keywords
neutralization assay
similar particles
human papilomavirus
pseudovirions
papilomavirus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69924007T
Other languages
German (de)
Other versions
DE69924007T2 (en
Inventor
U Jansen
D Yeager
M Keller
S Lowe
Miguel Aste-Amezaga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE69924007D1 publication Critical patent/DE69924007D1/en
Application granted granted Critical
Publication of DE69924007T2 publication Critical patent/DE69924007T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Pseudovirions, comprised of a papilloma virus-like particle (VLP) joined to a reporter gene construct are described. The pseudovirions can be used in assays to detect the presence of anti-VLP neutralizing antibodies. Also described are processes for making the pseudovirions.
DE69924007T 1998-12-23 1999-12-20 NEUTRALIZATION ASSAY USING HUMAN PAPILOMAVIRUS SIMILAR PARTICLES Expired - Fee Related DE69924007T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11338898P 1998-12-23 1998-12-23
US113388P 1998-12-23
PCT/US1999/030297 WO2000039151A1 (en) 1998-12-23 1999-12-20 Neutralizing assay using human papillomavirus virus-like particles

Publications (2)

Publication Number Publication Date
DE69924007D1 true DE69924007D1 (en) 2005-04-07
DE69924007T2 DE69924007T2 (en) 2006-04-06

Family

ID=22349108

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69924007T Expired - Fee Related DE69924007T2 (en) 1998-12-23 1999-12-20 NEUTRALIZATION ASSAY USING HUMAN PAPILOMAVIRUS SIMILAR PARTICLES

Country Status (8)

Country Link
EP (1) EP1140974B1 (en)
JP (1) JP2002535965A (en)
AT (1) ATE290013T1 (en)
AU (1) AU763853B2 (en)
CA (1) CA2355883A1 (en)
DE (1) DE69924007T2 (en)
ES (1) ES2237204T3 (en)
WO (1) WO2000039151A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60124725T2 (en) * 2000-07-07 2007-10-04 Merck & Co., Inc. PREPARATION OF A CHIMERIC PAPILLOMA VIRUS
EP1368058A4 (en) * 2001-03-02 2005-01-12 Merck & Co Inc Viral reporter particles
CA2497798A1 (en) * 2002-09-03 2004-04-22 Large Scale Biology Corporation Production of peptides in plants as viral coat protein fusions
MY140664A (en) * 2003-09-29 2010-01-15 Merck Sharp & Dohme Optimized expression of hpv 45 l1 in yeast
US20130149696A1 (en) * 2010-06-02 2013-06-13 European Molecular Biology Laboratory High-throughput method for determining the presence of papillomavirus-neutralizing antibodies in a sample

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPM566794A0 (en) * 1994-05-17 1994-06-09 University Of Queensland, The Process and product
US5795754A (en) * 1995-07-19 1998-08-18 Merck & Co., Inc. Synthetic HPV11 virus-like particles
CA2274474C (en) * 1996-12-09 2008-07-22 Steven Ludmerer Synthetic hpv16 virus-like particles

Also Published As

Publication number Publication date
ATE290013T1 (en) 2005-03-15
AU763853B2 (en) 2003-07-31
EP1140974A1 (en) 2001-10-10
EP1140974A4 (en) 2003-06-11
JP2002535965A (en) 2002-10-29
EP1140974B1 (en) 2005-03-02
ES2237204T3 (en) 2005-07-16
AU2371000A (en) 2000-07-31
DE69924007T2 (en) 2006-04-06
WO2000039151A1 (en) 2000-07-06
CA2355883A1 (en) 2000-07-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK & CO., INC., RAHWAY, N.J., US

8339 Ceased/non-payment of the annual fee