DE69831612D1 - PROCESS FOR PREPARATION OF 3 (2H) PYRIDAZINONE-4-SUBSTITUTED AMINO-5-CHLORO DERIVATIVES - Google Patents

PROCESS FOR PREPARATION OF 3 (2H) PYRIDAZINONE-4-SUBSTITUTED AMINO-5-CHLORO DERIVATIVES

Info

Publication number
DE69831612D1
DE69831612D1 DE69831612T DE69831612T DE69831612D1 DE 69831612 D1 DE69831612 D1 DE 69831612D1 DE 69831612 T DE69831612 T DE 69831612T DE 69831612 T DE69831612 T DE 69831612T DE 69831612 D1 DE69831612 D1 DE 69831612D1
Authority
DE
Germany
Prior art keywords
pyridazinone
preparation
substituted amino
chloro derivatives
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69831612T
Other languages
German (de)
Inventor
Nagy Peter Kotay
Gyula Simig
Jozsef Barkoczy
Ilona Sztruhar
Laszlo Balazs
Imre Doman
Zoltan Greff
Zoltan Ratkai
Peter Seres
Tamas Karancsi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EGIS GYOGYSZERGYAR BUDAPEST
Original Assignee
EGIS GYOGYSZERGYAR BUDAPEST
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS GYOGYSZERGYAR BUDAPEST filed Critical EGIS GYOGYSZERGYAR BUDAPEST
Application granted granted Critical
Publication of DE69831612D1 publication Critical patent/DE69831612D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/12—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention relates to novel processes for the preparation of 5-chloro-4-{3-[N-[2-(3,4-dimethoxyphenyl)-ethyl]-N-methylamino]-propylamino-3(2H) pyridazinone of formula (I) and the pharmaceutically acceptable acid addition salts thereof. An important feature of the invention is using 3,4,5-trichloropyridazone as starting substance of the synthesis.
DE69831612T 1998-06-05 1998-06-05 PROCESS FOR PREPARATION OF 3 (2H) PYRIDAZINONE-4-SUBSTITUTED AMINO-5-CHLORO DERIVATIVES Expired - Lifetime DE69831612D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/HU1998/000054 WO1999064402A1 (en) 1998-06-05 1998-06-05 Process for the preparation of a 3(2h)-pyridazinone- 4-substituted amino- 5-chloro- derivative

Publications (1)

Publication Number Publication Date
DE69831612D1 true DE69831612D1 (en) 2005-10-20

Family

ID=10990122

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69831612T Expired - Lifetime DE69831612D1 (en) 1998-06-05 1998-06-05 PROCESS FOR PREPARATION OF 3 (2H) PYRIDAZINONE-4-SUBSTITUTED AMINO-5-CHLORO DERIVATIVES

Country Status (15)

Country Link
US (1) US6800758B1 (en)
EP (1) EP1082309B1 (en)
JP (1) JP2004500314A (en)
KR (1) KR20010052598A (en)
CN (1) CN1205190C (en)
AT (1) ATE304535T1 (en)
AU (1) AU752967B2 (en)
BR (1) BR9815967A (en)
CA (1) CA2334220A1 (en)
DE (1) DE69831612D1 (en)
HK (1) HK1046529A1 (en)
MX (1) MXPA00012044A (en)
NO (1) NO318781B1 (en)
SK (1) SK18492000A3 (en)
WO (1) WO1999064402A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0103064A3 (en) * 2001-07-26 2005-06-28 Egis Gyogyszergyar Nyilvanosan Polymorphic form of 5-chloro-4-(3-{[2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amino]-propylamino)-3-(2h)-piridazinone fumarate, its use, process for its preparation and pharmaceutical compositions containing it
HU227237B1 (en) 2001-09-27 2010-12-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them
DK3174858T3 (en) 2014-07-31 2019-07-15 Basf Se PROCEDURE FOR THE PREPARATION OF PYRAZOLS
JP6833718B2 (en) 2015-05-11 2021-02-24 ビーエイエスエフ・ソシエタス・エウロパエアＢａｓｆ Ｓｅ Methods for Producing 4-Amino-Pyridazine
WO2018082964A1 (en) 2016-11-04 2018-05-11 Basf Se Process for the production of pyridazinyl-amides in a one-pot synthesis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3048487A1 (en) * 1980-12-22 1982-07-29 Cassella Ag, 6000 Frankfurt BASICLY SUBSTITUTED PYRIDAZINE, THEIR PRODUCTION AND THEIR USE
HU214320B (en) 1991-12-20 1998-03-02 EGIS Gyógyszergyár Rt. Process for producing novel 3(2h)-pyridazinon derivatives and pharmaceutical compositions producing them

Also Published As

Publication number Publication date
MXPA00012044A (en) 2002-04-24
CN1205190C (en) 2005-06-08
AU752967B2 (en) 2002-10-03
AU7783498A (en) 1999-12-30
JP2004500314A (en) 2004-01-08
EP1082309B1 (en) 2005-09-14
SK18492000A3 (en) 2001-06-11
CA2334220A1 (en) 1999-12-16
HK1046529A1 (en) 2003-01-17
BR9815967A (en) 2004-06-22
US6800758B1 (en) 2004-10-05
NO20006183D0 (en) 2000-12-05
WO1999064402A1 (en) 1999-12-16
NO20006183L (en) 2001-01-30
CN1347407A (en) 2002-05-01
ATE304535T1 (en) 2005-09-15
NO318781B1 (en) 2005-05-09
KR20010052598A (en) 2001-06-25
EP1082309A1 (en) 2001-03-14

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Legal Events

Date Code Title Description
8332 No legal effect for de