DE69829984D1 - Modulatoren der cytosin-5-methyl-transferase und verfahren zu ihrer verwendung - Google Patents

Modulatoren der cytosin-5-methyl-transferase und verfahren zu ihrer verwendung

Info

Publication number
DE69829984D1
DE69829984D1 DE69829984T DE69829984T DE69829984D1 DE 69829984 D1 DE69829984 D1 DE 69829984D1 DE 69829984 T DE69829984 T DE 69829984T DE 69829984 T DE69829984 T DE 69829984T DE 69829984 D1 DE69829984 D1 DE 69829984D1
Authority
DE
Germany
Prior art keywords
dna
synthetic oligonucleotide
inhibiting
methylation
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69829984T
Other languages
English (en)
Inventor
O Reich
James Flynn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Application granted granted Critical
Publication of DE69829984D1 publication Critical patent/DE69829984D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
DE69829984T 1997-08-29 1998-06-12 Modulatoren der cytosin-5-methyl-transferase und verfahren zu ihrer verwendung Expired - Lifetime DE69829984D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5741197P 1997-08-29 1997-08-29
PCT/US1998/012351 WO1999012027A1 (en) 1997-08-29 1998-06-12 Modulators of dna cytosine-5 methyltransferase and methods for use thereof

Publications (1)

Publication Number Publication Date
DE69829984D1 true DE69829984D1 (de) 2005-06-02

Family

ID=22010427

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69829984T Expired - Lifetime DE69829984D1 (de) 1997-08-29 1998-06-12 Modulatoren der cytosin-5-methyl-transferase und verfahren zu ihrer verwendung

Country Status (6)

Country Link
EP (1) EP1018003B1 (de)
JP (1) JP2001514862A (de)
AT (1) ATE294388T1 (de)
CA (1) CA2300354A1 (de)
DE (1) DE69829984D1 (de)
WO (1) WO1999012027A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790955B1 (fr) 1999-03-19 2003-01-17 Assist Publ Hopitaux De Paris Utilisation d'oligonucleotides stabilises comme principe actif antitumoral
US6890736B1 (en) 2002-09-20 2005-05-10 Immunex Corporation Methods for producing proteins in cultured cells
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
WO2011018435A1 (en) 2009-08-10 2011-02-17 Institut Curie Method for predicting the sensitivity of a tumor to an epigenetic treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578716A (en) * 1993-12-01 1996-11-26 Mcgill University DNA methyltransferase antisense oligonucleotides
US5652105A (en) * 1995-07-28 1997-07-29 Health Research, Inc. Substrate for detection of mammalian 5-C-DNA methyltransferase
CA2256305A1 (en) * 1996-05-22 1997-11-27 Mcgill University Specific inhibitors of dna methyltransferase enzyme

Also Published As

Publication number Publication date
EP1018003A4 (de) 2002-04-17
EP1018003B1 (de) 2005-04-27
ATE294388T1 (de) 2005-05-15
EP1018003A1 (de) 2000-07-12
CA2300354A1 (en) 1999-03-11
JP2001514862A (ja) 2001-09-18
WO1999012027A1 (en) 1999-03-11

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Legal Events

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