DE69811677T2 - METHOD FOR THE PREPARATION OF ENANTIOMER-ENRICHED, N-DERIVATIVED LACTAMES. - Google Patents

METHOD FOR THE PREPARATION OF ENANTIOMER-ENRICHED, N-DERIVATIVED LACTAMES.

Info

Publication number
DE69811677T2
DE69811677T2 DE69811677T DE69811677T DE69811677T2 DE 69811677 T2 DE69811677 T2 DE 69811677T2 DE 69811677 T DE69811677 T DE 69811677T DE 69811677 T DE69811677 T DE 69811677T DE 69811677 T2 DE69811677 T2 DE 69811677T2
Authority
DE
Germany
Prior art keywords
lactames
derivatived
enantiomer
enriched
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69811677T
Other languages
German (de)
Other versions
DE69811677D1 (en
Inventor
Michael John Dawson
Mahmoud Mahmoudian
Christopher John Wallis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE69811677D1 publication Critical patent/DE69811677D1/en
Application granted granted Critical
Publication of DE69811677T2 publication Critical patent/DE69811677T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69811677T 1997-08-22 1998-08-20 METHOD FOR THE PREPARATION OF ENANTIOMER-ENRICHED, N-DERIVATIVED LACTAMES. Expired - Lifetime DE69811677T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9717928.7A GB9717928D0 (en) 1997-08-22 1997-08-22 Process for the enatioselective hydrolysis of n-derivatised lactams
PCT/EP1998/005291 WO1999010519A1 (en) 1997-08-22 1998-08-20 Process for preparing enantiomerically enriched n-derivatised lactams

Publications (2)

Publication Number Publication Date
DE69811677D1 DE69811677D1 (en) 2003-04-03
DE69811677T2 true DE69811677T2 (en) 2003-10-16

Family

ID=10817952

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69811677T Expired - Lifetime DE69811677T2 (en) 1997-08-22 1998-08-20 METHOD FOR THE PREPARATION OF ENANTIOMER-ENRICHED, N-DERIVATIVED LACTAMES.

Country Status (35)

Country Link
US (1) US6340587B1 (en)
EP (1) EP1003903B1 (en)
JP (1) JP3565868B2 (en)
KR (1) KR100479894B1 (en)
CN (1) CN1133749C (en)
AP (1) AP1104A (en)
AR (1) AR016395A1 (en)
AT (1) ATE233323T1 (en)
AU (1) AU738897B2 (en)
BR (1) BR9810472B1 (en)
CA (1) CA2295017A1 (en)
CZ (1) CZ294302B6 (en)
DE (1) DE69811677T2 (en)
DK (1) DK1003903T3 (en)
EA (1) EA001964B1 (en)
EE (1) EE03934B1 (en)
ES (1) ES2193568T3 (en)
GB (1) GB9717928D0 (en)
HK (1) HK1025796A1 (en)
HR (1) HRP990408B1 (en)
HU (1) HU222657B1 (en)
ID (1) ID25830A (en)
IL (1) IL133541A (en)
IN (1) IN183908B (en)
IS (1) IS2201B (en)
NO (1) NO320081B1 (en)
NZ (1) NZ501880A (en)
PL (1) PL191108B1 (en)
PT (1) PT1003903E (en)
RS (1) RS49542B (en)
SI (1) SI1003903T1 (en)
SK (1) SK282782B6 (en)
TR (1) TR199903210T2 (en)
TW (1) TW589301B (en)
WO (1) WO1999010519A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1095160B1 (en) * 1998-07-09 2004-01-28 Lonza AG Method for producing (1r,4s)-2-azabicyclo 2.2.1 hept-5-en-3-on derivatives.
DE19962543A1 (en) * 1999-12-23 2001-07-05 Degussa Chromatographic separation of enantiomers of bicyclic lactams
US6780635B2 (en) * 2001-12-27 2004-08-24 Council Of Scientific And Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
EP1348765B1 (en) * 2002-03-28 2006-05-24 Council of Scientific and Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
HU227663B1 (en) * 2007-07-09 2011-10-28 Univ Szegedi Resolution process
WO2011094150A1 (en) 2010-01-27 2011-08-04 Glaxosmithkline Llc Antiviral therapy
CN103695495B (en) * 2014-01-14 2014-08-27 营口三征新科技化工有限公司 Method for preparing (1R, 4s)-(-)-2-azabicyclo[2,2,1]hepta-5-ene-3-one

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424064B1 (en) 1989-10-16 1995-02-08 Chiroscience Limited Chiral azabicyloheptanone and a process for their preparation
GB9108384D0 (en) 1991-04-19 1991-06-05 Enzymatix Ltd Bicycloheptanes
SK285228B6 (en) * 1997-05-13 2006-09-07 Lonza Ag Process for the preparation of a racemic or optically active 4-(hydroxymethyl)-2-cyclopentene derivative and racemic N-butyryl-1-amino-4-(hydroxymethyl)-2-cyclopentene

Also Published As

Publication number Publication date
SK184499A3 (en) 2000-09-12
CN1261405A (en) 2000-07-26
BR9810472A (en) 2000-09-19
DE69811677D1 (en) 2003-04-03
JP2001504354A (en) 2001-04-03
YU69399A (en) 2002-06-19
ES2193568T3 (en) 2003-11-01
BR9810472B1 (en) 2011-01-11
EP1003903A1 (en) 2000-05-31
TR199903210T2 (en) 2000-07-21
CN1133749C (en) 2004-01-07
PL191108B1 (en) 2006-03-31
KR100479894B1 (en) 2005-03-30
AP1104A (en) 2002-09-04
CZ471699A3 (en) 2000-06-14
CZ294302B6 (en) 2004-11-10
SK282782B6 (en) 2002-12-03
IS2201B (en) 2007-02-15
EE200000075A (en) 2000-10-16
EA001964B1 (en) 2001-10-22
DK1003903T3 (en) 2003-06-10
SI1003903T1 (en) 2003-08-31
HUP0002661A3 (en) 2001-12-28
HRP990408B1 (en) 2006-05-31
HU222657B1 (en) 2003-09-29
HK1025796A1 (en) 2000-11-24
PT1003903E (en) 2003-06-30
NO996368D0 (en) 1999-12-21
ID25830A (en) 2000-11-09
JP3565868B2 (en) 2004-09-15
IS5297A (en) 1999-12-14
HUP0002661A2 (en) 2000-12-28
IL133541A (en) 2003-10-31
US6340587B1 (en) 2002-01-22
AU738897B2 (en) 2001-09-27
WO1999010519A1 (en) 1999-03-04
HRP990408A2 (en) 2000-04-30
TW589301B (en) 2004-06-01
PL337647A1 (en) 2000-08-28
NO320081B1 (en) 2005-10-17
IN183908B (en) 2000-05-13
GB9717928D0 (en) 1997-10-29
RS49542B (en) 2007-02-05
NZ501880A (en) 2001-08-31
EE03934B1 (en) 2002-12-16
NO996368L (en) 2000-02-21
EA199901059A1 (en) 2000-08-28
ATE233323T1 (en) 2003-03-15
EP1003903B1 (en) 2003-02-26
AP9901721A0 (en) 1999-12-31
AR016395A1 (en) 2001-07-04
AU9738698A (en) 1999-03-16
IL133541A0 (en) 2001-04-30
KR20010014078A (en) 2001-02-26
CA2295017A1 (en) 1999-03-04

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