DE69738965D1 - Detoxification by intramuscularly administered F (ab ') 2 fragments - Google Patents

Detoxification by intramuscularly administered F (ab ') 2 fragments

Info

Publication number
DE69738965D1
DE69738965D1 DE69738965T DE69738965T DE69738965D1 DE 69738965 D1 DE69738965 D1 DE 69738965D1 DE 69738965 T DE69738965 T DE 69738965T DE 69738965 T DE69738965 T DE 69738965T DE 69738965 D1 DE69738965 D1 DE 69738965D1
Authority
DE
Germany
Prior art keywords
drugs
fragments
detoxification
animals treated
description
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69738965T
Other languages
German (de)
Inventor
Ivo Volpato
Bernard Bizzini
Ernst Bernhard Grabitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dox Al Italia SpA
Original Assignee
Dox Al Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dox Al Italia SpA filed Critical Dox Al Italia SpA
Application granted granted Critical
Publication of DE69738965D1 publication Critical patent/DE69738965D1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A description is given of F(ab')2 fragments and corresponding IgG immunoglobulins, active as specific antibodies to drugs and metabolites thereof, and their use in the treatment for detoxifying humans and animals treated with said drugs. Said fragments are obtained by removing the Fc fragment of IgG immunoglobulins obtained from the serum of animals treated with immunogen derivatives of said drugs, which, on their turn, are obtained by conjugating said drugs with proteic or polysaccharide carriers. The description also sets forth a competitive immunodiagnostic method for the determination of drugs in biological fluids and the corresponding diagnostic kit.
DE69738965T 1996-06-27 1997-06-26 Detoxification by intramuscularly administered F (ab ') 2 fragments Expired - Fee Related DE69738965D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI001309A IT1284076B1 (en) 1996-06-27 1996-06-27 F(AB')2 FRAGMENTS AND THEIR IMMUNOGLOBULINS IGG, ACTIVE AS SPECIFIC ANTIBODY TOWARDS DRUGS AND THEIR METABOLITES, AND THEIR
PCT/EP1997/003358 WO1997049732A1 (en) 1996-06-27 1997-06-26 IgG IMMUNOGLOBULINS AND F(ab')2 FRAGMENTS THEREOF, SPECIFIC FOR DRUGS AND METABOLITES THEREOF, AND THEIR USE FOR DETOXIFICATION PURPOSES

Publications (1)

Publication Number Publication Date
DE69738965D1 true DE69738965D1 (en) 2008-10-16

Family

ID=11374491

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69738965T Expired - Fee Related DE69738965D1 (en) 1996-06-27 1997-06-26 Detoxification by intramuscularly administered F (ab ') 2 fragments

Country Status (6)

Country Link
EP (1) EP0934339B1 (en)
AT (1) ATE407149T1 (en)
AU (1) AU3437497A (en)
DE (1) DE69738965D1 (en)
IT (1) IT1284076B1 (en)
WO (1) WO1997049732A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9705376D0 (en) * 1997-03-14 1997-04-30 Harris William J Antibody fragment formulations and assay formats for detecting the presence an d concentration of analytes
GB0003360D0 (en) 2000-02-14 2000-04-05 Novartis Ag Monoclonal antibodies
WO2001081424A1 (en) * 2000-04-20 2001-11-01 The Board Of Trustees Of The University Of Arkansas Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs
US6669937B2 (en) * 2000-04-20 2003-12-30 The Board Of Trustees Of The University Of Arkansas Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs
US7632929B2 (en) 2000-04-20 2009-12-15 The Board Of Trustees Of The University Of Arkansas Methamphetamine-like hapten compounds, linkers, carriers and compositions and uses thereof
ITMI20010347A1 (en) 2001-02-21 2002-08-21 Grisotech S A IMMUNOGLOBULIN AND POLYSACCHARID COMPLEXES FOR ORAL ABSORPTION ETRANS-MUCOSAL
EP1331219A1 (en) * 2002-01-23 2003-07-30 Drug Abuse Sciences, Inc. New amphetamine derivatives, antibodies against them and pharmaceutical compositions containing them
ES2415655T3 (en) 2006-06-15 2013-07-26 The Board Of Trustees Of The University Of Arkansas Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine-like compounds
US8853146B2 (en) 2007-04-20 2014-10-07 The Board Of Trustees Of The University Of Arkansas Hapten compounds and compositions and uses thereof
US9023353B2 (en) 2013-03-13 2015-05-05 The Board Of Trustees Of The University Of Arkansas Anti-(+)—methamphetamine monoclonal antibodies
CN111060690B (en) * 2019-10-08 2023-07-07 浙江工商大学 Time-resolved fluoroimmunoassay kit for detecting olaquindox and application thereof
CN111154000A (en) * 2020-01-16 2020-05-15 新乡学院 Anti-cimaterol monoclonal antibody and application thereof
CN111269319B (en) * 2020-02-21 2021-10-29 华南农业大学 Specific nano antibody Nb2F7 and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1064396A (en) * 1975-02-18 1979-10-16 Myer L. Coval Fractional precipitation of gamma globulin with polyethylene glycol

Also Published As

Publication number Publication date
IT1284076B1 (en) 1998-05-08
ITMI961309A1 (en) 1997-12-27
WO1997049732A1 (en) 1997-12-31
EP0934339A1 (en) 1999-08-11
ITMI961309A0 (en) 1996-06-27
EP0934339B1 (en) 2008-09-03
AU3437497A (en) 1998-01-14
ATE407149T1 (en) 2008-09-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee