DE69737126D1 - HBV MUTANTS AND METHODS FOR IDENTIFICATION - Google Patents

HBV MUTANTS AND METHODS FOR IDENTIFICATION

Info

Publication number
DE69737126D1
DE69737126D1 DE69737126T DE69737126T DE69737126D1 DE 69737126 D1 DE69737126 D1 DE 69737126D1 DE 69737126 T DE69737126 T DE 69737126T DE 69737126 T DE69737126 T DE 69737126T DE 69737126 D1 DE69737126 D1 DE 69737126D1
Authority
DE
Germany
Prior art keywords
viral
present
identification
methods
assays
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69737126T
Other languages
German (de)
Other versions
DE69737126T2 (en
Inventor
Alister Locarnini
Ingrid Bartholomeusz
Thein Aye
Man A De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Melbourne Health
Original Assignee
Melbourne Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melbourne Health filed Critical Melbourne Health
Application granted granted Critical
Publication of DE69737126D1 publication Critical patent/DE69737126D1/en
Publication of DE69737126T2 publication Critical patent/DE69737126T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The present invention relates generally to viral variants exhibiting reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B variants exhibiting complete or partial resistance to nucleoside analogs and/or reduced interactivity with antibodies to viral surface components. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic agents.
DE69737126T 1996-11-08 1997-08-15 HBV MUTANTS AND METHODS FOR IDENTIFICATION Expired - Lifetime DE69737126T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPO351996 1996-11-08
AUPO3519A AUPO351996A0 (en) 1996-11-08 1996-11-08 Viral variants and methods for detecting same
PCT/AU1997/000520 WO1998021317A1 (en) 1996-11-08 1997-08-15 Viral variants and methods for detecting same

Publications (2)

Publication Number Publication Date
DE69737126D1 true DE69737126D1 (en) 2007-02-01
DE69737126T2 DE69737126T2 (en) 2007-10-04

Family

ID=3797830

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69737126T Expired - Lifetime DE69737126T2 (en) 1996-11-08 1997-08-15 HBV MUTANTS AND METHODS FOR IDENTIFICATION

Country Status (10)

Country Link
US (4) US6555311B1 (en)
EP (1) EP0964916B1 (en)
JP (4) JP2001503277A (en)
AT (1) ATE348880T1 (en)
AU (1) AUPO351996A0 (en)
CA (1) CA2270178C (en)
DE (1) DE69737126T2 (en)
ES (1) ES2279542T3 (en)
HK (1) HK1027374A1 (en)
WO (1) WO1998021317A1 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA973367B (en) 1996-04-19 1997-11-18 Innogenetics Nv Method for typing and detecting HBV.
AUPO351996A0 (en) * 1996-11-08 1996-12-05 Western Health Care Network Viral variants and methods for detecting same
USRE40233E1 (en) 1996-11-08 2008-04-08 Melbourne Health Viral variants and methods for detecting same
AUPP706098A0 (en) * 1998-11-11 1998-12-03 North Western Health Care Network Biological compositions, components thereof and uses therefor
AUPP967999A0 (en) 1999-04-09 1999-05-06 North Western Health Care Network Viral variants
AR028149A1 (en) * 1999-07-08 2003-04-30 Innogenetics Nv DETECTION OF RESISTANCE TO DRUGS AGAINST HEPATITIS B
AUPQ810900A0 (en) 2000-06-09 2000-07-06 Austin and Repatriation Medical Centre, The Viral variants and methods of using same
SG90149A1 (en) * 2000-07-18 2002-07-23 Government Of The Republic Of Diagnostic assay
US6697858B1 (en) * 2000-08-14 2004-02-24 Telephony@Work Call center
US7405039B2 (en) 2002-02-07 2008-07-29 Austin Health Viral variants with altered susceptibility to nucleoside analogs and uses thereof
EP2319917A3 (en) * 2002-02-07 2012-02-08 Melbourne Health Viral variants with altered susceptibility to nucleoside analogs and uses thereof
CA2480382C (en) 2002-03-29 2015-12-22 Innogenetics N.V. Hbv drug resistance detection methods
AU2003213874B2 (en) * 2002-04-12 2008-12-04 Austin Health Hepatitis B viral variants with redused susceptibility to nucleoside analogs and uses thereof
EP1499712A4 (en) 2002-04-12 2008-04-16 Melbourne Health Hepatitis b viral variants with reduced susceptibility to nucleoside analogs and uses thereof
WO2003106714A1 (en) 2002-06-14 2003-12-24 Gen-Probe Incorporated Compositions and methods for detecting hepatitis b virus
AU2003277208A1 (en) * 2002-10-01 2004-04-23 Georgetown University Diagnostic for long term response of hbv carrier to 3tc therapy
PL1858915T3 (en) 2005-03-15 2015-01-30 Univ Bonn Rheinische Friedrich Wilhelms Variants of hepatitis b virus resistant against some nucleoside analogues, but sensitive to others, and uses thereof
JP2008537483A (en) 2005-03-15 2008-09-18 イノジェネティックス・ナムローゼ・フェンノートシャップ Hepatitis B virus variants with reduced sensitivity to nucleoside analogues and uses thereof
US8211443B2 (en) 2005-04-08 2012-07-03 Melbourne Health Variants of hepatitis B virus with resistance to anti-viral nucleoside agents and applications thereof
JP2008534020A (en) 2005-04-08 2008-08-28 メルボルン ヘルス Hepatitis B virus variant resistant to antiviral nucleoside agents and application method thereof
KR100790226B1 (en) 2005-11-03 2008-01-02 연세대학교 산학협력단 Method for determining the susceptibility to toxic hepatitis
US9175338B2 (en) * 2008-12-11 2015-11-03 Pacific Biosciences Of California, Inc. Methods for identifying nucleic acid modifications
WO2010068289A2 (en) * 2008-12-11 2010-06-17 Pacific Biosciences Of California, Inc. Classification of nucleic acid templates
US20230148447A9 (en) 2008-12-11 2023-05-11 Pacific Biosciences Of California, Inc. Classification of nucleic acid templates
US9611510B2 (en) 2011-04-06 2017-04-04 The University Of Chicago Composition and methods related to modification of 5-methylcytosine (5-mC)
US9238836B2 (en) 2012-03-30 2016-01-19 Pacific Biosciences Of California, Inc. Methods and compositions for sequencing modified nucleic acids
US9175348B2 (en) 2012-04-24 2015-11-03 Pacific Biosciences Of California, Inc. Identification of 5-methyl-C in nucleic acid templates
JP2023505304A (en) * 2019-12-07 2023-02-08 アイエスエー ファーマシューティカルズ ビー．ヴイ． Treatment of diseases associated with hepatitis B virus

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595739A (en) * 1993-05-07 1997-01-21 Abbott Laboratories Hepatitis B virus mutants, reagents and methods for detection
ZA973367B (en) * 1996-04-19 1997-11-18 Innogenetics Nv Method for typing and detecting HBV.
USRE40233E1 (en) * 1996-11-08 2008-04-08 Melbourne Health Viral variants and methods for detecting same
AUPO351996A0 (en) * 1996-11-08 1996-12-05 Western Health Care Network Viral variants and methods for detecting same
AUPP967999A0 (en) * 1999-04-09 1999-05-06 North Western Health Care Network Viral variants
AUPQ810900A0 (en) * 2000-06-09 2000-07-06 Austin and Repatriation Medical Centre, The Viral variants and methods of using same
US7405039B2 (en) * 2002-02-07 2008-07-29 Austin Health Viral variants with altered susceptibility to nucleoside analogs and uses thereof
CA2480382C (en) * 2002-03-29 2015-12-22 Innogenetics N.V. Hbv drug resistance detection methods
EP1499712A4 (en) * 2002-04-12 2008-04-16 Melbourne Health Hepatitis b viral variants with reduced susceptibility to nucleoside analogs and uses thereof
KR20130049210A (en) * 2003-10-21 2013-05-13 멜버른 헬스 Hbv variants detection and application
JP2008537483A (en) * 2005-03-15 2008-09-18 イノジェネティックス・ナムローゼ・フェンノートシャップ Hepatitis B virus variants with reduced sensitivity to nucleoside analogues and uses thereof
PL1858915T3 (en) * 2005-03-15 2015-01-30 Univ Bonn Rheinische Friedrich Wilhelms Variants of hepatitis b virus resistant against some nucleoside analogues, but sensitive to others, and uses thereof
JP2008534020A (en) * 2005-04-08 2008-08-28 メルボルン ヘルス Hepatitis B virus variant resistant to antiviral nucleoside agents and application method thereof
US8211443B2 (en) * 2005-04-08 2012-07-03 Melbourne Health Variants of hepatitis B virus with resistance to anti-viral nucleoside agents and applications thereof
KR101489342B1 (en) * 2006-06-06 2015-02-11 멜버른 헬스 Detection and use of antiviral resistance mutations

Also Published As

Publication number Publication date
CA2270178A1 (en) 1998-05-22
EP0964916A1 (en) 1999-12-22
EP0964916A4 (en) 2001-09-26
ES2279542T3 (en) 2007-08-16
WO1998021317A1 (en) 1998-05-22
DE69737126T2 (en) 2007-10-04
ATE348880T1 (en) 2007-01-15
CA2270178C (en) 2012-06-12
US20030124096A1 (en) 2003-07-03
HK1027374A1 (en) 2001-01-12
US20100203506A1 (en) 2010-08-12
JP2001503277A (en) 2001-03-13
US20130171620A1 (en) 2013-07-04
JP2015107127A (en) 2015-06-11
EP0964916B1 (en) 2006-12-20
JP2008154590A (en) 2008-07-10
JP2012055322A (en) 2012-03-22
AUPO351996A0 (en) 1996-12-05
US6555311B1 (en) 2003-04-29

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