DE69632716D1 - METHOD FOR DRUG EXAMINATION - Google Patents

METHOD FOR DRUG EXAMINATION

Info

Publication number
DE69632716D1
DE69632716D1 DE69632716T DE69632716T DE69632716D1 DE 69632716 D1 DE69632716 D1 DE 69632716D1 DE 69632716 T DE69632716 T DE 69632716T DE 69632716 T DE69632716 T DE 69632716T DE 69632716 D1 DE69632716 D1 DE 69632716D1
Authority
DE
Germany
Prior art keywords
organism
reporter gene
cell
drug
transcriptional
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69632716T
Other languages
German (de)
Other versions
DE69632716T2 (en
Inventor
Matthew Ashby
Jasper Rine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
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Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24040680&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69632716(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of California filed Critical University of California
Publication of DE69632716D1 publication Critical patent/DE69632716D1/en
Application granted granted Critical
Publication of DE69632716T2 publication Critical patent/DE69632716T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Methods and compositions for modeling the transcriptional responsiveness of an organism to a candidate drug involve (a) detecting reporter gene product signals from each of a plurality of different, separately isolated cells of a target organism, wherein each cell contains a recombinant construct comprising a reporter gene operatively linked to a different endogenous transcriptional regulatory element of the target organism such that the transcriptional regulatory element regulates the expression of the reporter gene, and the sum of the cells comprises an ensemble of the transcriptional regulatory elements of the organism sufficient to model the transcriptional responsiveness of said organism to a drug; (b) contacting each cell with a candidate drug; (c) detecting reporter gene product signals from each cell; (d) comparing reporter gene product signals from each cell before and after contacting the cell with the candidate drug to obtain a drug response profile which provides a model of the transcriptional responsiveness of said organism to the candidate drug.
DE69632716T 1995-08-09 1996-08-09 METHOD FOR DRUG TESTING Expired - Lifetime DE69632716T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/512,811 US5569588A (en) 1995-08-09 1995-08-09 Methods for drug screening
US512811 1995-08-09
PCT/US1996/012956 WO1997006277A1 (en) 1995-08-09 1996-08-09 Methods for drug screening

Publications (2)

Publication Number Publication Date
DE69632716D1 true DE69632716D1 (en) 2004-07-22
DE69632716T2 DE69632716T2 (en) 2005-07-07

Family

ID=24040680

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69632716T Expired - Lifetime DE69632716T2 (en) 1995-08-09 1996-08-09 METHOD FOR DRUG TESTING

Country Status (10)

Country Link
US (1) US5569588A (en)
EP (1) EP0791078B1 (en)
JP (1) JPH10507647A (en)
AT (1) ATE269414T1 (en)
AU (1) AU724474B2 (en)
CA (1) CA2202154C (en)
DE (1) DE69632716T2 (en)
DK (1) DK0791078T3 (en)
ES (1) ES2219692T3 (en)
WO (1) WO1997006277A1 (en)

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