DE69630145D1 - TAXAL DERIVATIVES, THEIR PRODUCTION AND THEIR PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
TAXAL DERIVATIVES, THEIR PRODUCTION AND THEIR PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- DE69630145D1 DE69630145D1 DE69630145T DE69630145T DE69630145D1 DE 69630145 D1 DE69630145 D1 DE 69630145D1 DE 69630145 T DE69630145 T DE 69630145T DE 69630145 T DE69630145 T DE 69630145T DE 69630145 D1 DE69630145 D1 DE 69630145D1
- Authority
- DE
- Germany
- Prior art keywords
- taxal
- derivatives
- production
- pharmaceutical compositions
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9515379 | 1995-12-22 | ||
FR9515379A FR2742751B1 (en) | 1995-12-22 | 1995-12-22 | NOVEL TAXOIDS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
PCT/FR1996/002031 WO1997023473A1 (en) | 1995-12-22 | 1996-12-19 | Novel taxoids, preparation thereof and pharmaceutical compositions containing same |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69630145D1 true DE69630145D1 (en) | 2003-10-30 |
DE69630145T2 DE69630145T2 (en) | 2004-07-15 |
Family
ID=9485871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69630145T Expired - Lifetime DE69630145T2 (en) | 1995-12-22 | 1996-12-19 | TAXAL DERIVATIVES, THEIR PRODUCTION AND THEIR PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (41)
Country | Link |
---|---|
US (1) | US5728849A (en) |
EP (1) | EP0876362B1 (en) |
JP (1) | JP3953106B2 (en) |
KR (1) | KR100500351B1 (en) |
CN (1) | CN1103766C (en) |
AR (1) | AR005197A1 (en) |
AT (1) | ATE250593T1 (en) |
AU (1) | AU712597B2 (en) |
BG (1) | BG63204B1 (en) |
BR (1) | BR9612135A (en) |
CA (1) | CA2238884C (en) |
CO (1) | CO4520184A1 (en) |
CZ (1) | CZ294972B6 (en) |
DE (1) | DE69630145T2 (en) |
DK (1) | DK0876362T3 (en) |
DZ (1) | DZ2149A1 (en) |
EA (1) | EA001533B1 (en) |
ES (1) | ES2202490T3 (en) |
FR (1) | FR2742751B1 (en) |
HK (1) | HK1017895A1 (en) |
HU (1) | HU225032B1 (en) |
IL (1) | IL124994A (en) |
IN (4) | IN186768B (en) |
MA (1) | MA26412A1 (en) |
MX (1) | MX9804688A (en) |
MY (1) | MY113934A (en) |
NO (1) | NO317358B1 (en) |
NZ (1) | NZ324337A (en) |
OA (1) | OA10700A (en) |
PE (1) | PE25198A1 (en) |
PL (1) | PL189311B1 (en) |
PT (1) | PT876362E (en) |
RO (1) | RO116194B1 (en) |
SK (1) | SK282835B6 (en) |
TN (1) | TNSN96169A1 (en) |
TR (1) | TR199801179T2 (en) |
TW (1) | TW371659B (en) |
UA (1) | UA48205C2 (en) |
UY (1) | UY24386A1 (en) |
WO (1) | WO1997023473A1 (en) |
ZA (1) | ZA9610737B (en) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9920548D0 (en) * | 1999-08-31 | 1999-11-03 | Rhone Poulenc Rorer Sa | Treatment of hepatocellular carcinoma |
MXPA01009902A (en) | 2000-02-02 | 2003-07-28 | Univ Florida State Res Found | C10 carbonate substituted taxanes as antitumor agents. |
DK1953162T3 (en) * | 2001-02-24 | 2012-09-10 | Boehringer Ingelheim Pharma | Xanthine derivatives, their preparation and their use as a drug. |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
EP1663153A4 (en) * | 2003-05-20 | 2011-01-05 | Aronex Pharmaceuticals Inc | Combination chemotherapy comprising a liposomal platinum complex |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004054054A1 (en) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Process for preparing chiral 8- (3-amino-piperidin-1-yl) -xanthines |
EP1669358A1 (en) * | 2004-12-07 | 2006-06-14 | Aventis Pharma S.A. | Cytotoxic agents comprising new taxanes |
DE102005035891A1 (en) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8- (3-amino-piperidin-1-yl) -xanthines, their preparation and their use as pharmaceuticals |
PE20080251A1 (en) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | USES OF DPP IV INHIBITORS |
EP2540725A1 (en) * | 2006-05-04 | 2013-01-02 | Boehringer Ingelheim International GmbH | Polymorphs of 1-((4-Methyl-chinazolin-2-yl)methyl)-3-methyl-7-(2-butin-1-yl)-8-(3-(R)-amino-piperidin-1-yl)xanthin |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
US20080207743A1 (en) * | 2007-02-28 | 2008-08-28 | Rodger Lamb | Biologically Active Taxane Analogs and Methods of Treatment |
EP3542801A1 (en) * | 2007-08-17 | 2019-09-25 | Boehringer Ingelheim International GmbH | Purin derivatives for use in the treatment of fap-related diseases |
PE20140960A1 (en) | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | FORMULATIONS INVOLVING A DPP4 INHIBITOR |
PE20100156A1 (en) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | NAFLD TREATMENT |
UY32030A (en) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "TREATMENT FOR DIABETES IN INAPPROPRIATE PATIENTS FOR THERAPY WITH METFORMIN" |
KR20190016601A (en) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | Treatment for diabetes in patients inappropriate for metformin therapy |
PE20110297A1 (en) * | 2008-08-15 | 2011-05-26 | Boehringer Ingelheim Int | DPP-4 INHIBITORS FOR WOUND HEALING |
RU2011113823A (en) | 2008-09-10 | 2012-10-20 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | COMBINED THERAPY FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
JP2012512848A (en) | 2008-12-23 | 2012-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Salt forms of organic compounds |
TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
NZ599298A (en) | 2009-11-27 | 2014-11-28 | Boehringer Ingelheim Int | Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin |
JP6034781B2 (en) | 2010-05-05 | 2016-11-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Combination therapy |
EP3725325B1 (en) | 2010-06-24 | 2023-05-31 | Boehringer Ingelheim International GmbH | Diabetes therapy |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
DK2731947T3 (en) | 2011-07-15 | 2019-04-23 | Boehringer Ingelheim Int | SUBSTITUTED DIMERIC QUINAZOLINE DERIVATIVE, PREPARATION AND USE thereof IN PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF TYPE I AND TYPE II DIABETES |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
EP2849755A1 (en) | 2012-05-14 | 2015-03-25 | Boehringer Ingelheim International GmbH | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
CA2891280C (en) | 2012-11-24 | 2018-03-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
FR3010839B1 (en) * | 2013-09-17 | 2017-04-21 | Schneider Electric Ind Sas | DEVICE FOR ELECTRICALLY CONNECTING AT LEAST ONE CONDUCTOR IN A TERMINAL BELONGING TO AN ELECTRICAL APPARATUS |
JP6615109B2 (en) | 2014-02-28 | 2019-12-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Medical use of DPP-4 inhibitors |
EP3122757B1 (en) | 2014-02-28 | 2023-09-06 | Hangzhou Dac Biotech Co., Ltd | Charged linkers and their uses for conjugation |
CN113350518A (en) | 2015-07-12 | 2021-09-07 | 杭州多禧生物科技有限公司 | Conjugated bridge linkers to cell binding molecules |
US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
CA3022202A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
JP7138350B2 (en) | 2016-11-14 | 2022-09-16 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ. | Conjugate conjugates, cell-binding molecule-drug conjugates containing the conjugates, and methods of using and producing the conjugates and conjugates |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2017724C1 (en) * | 1990-07-12 | 1994-08-15 | Дзе Юниверсити оф Канзас | Method of synthesis of taxol derivatives |
US5059699A (en) * | 1990-08-28 | 1991-10-22 | Virginia Tech Intellectual Properties, Inc. | Water soluble derivatives of taxol |
FR2678930B1 (en) * | 1991-07-10 | 1995-01-13 | Rhone Poulenc Rorer Sa | PROCESS FOR THE PREPARATION OF DERIVATIVES OF BACCATIN III AND DESACETYL-10 BACCATIN III. |
RU2059631C1 (en) * | 1991-11-29 | 1996-05-10 | Дзе Юниверсити оф Канзас | Derivatives of taxol and pharmaceutical composition showing antitumor activity |
ATE181551T1 (en) * | 1992-04-17 | 1999-07-15 | Abbott Lab | TAXOL DERIVATIVES |
US5254580A (en) * | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
IL107950A (en) * | 1992-12-15 | 2001-04-30 | Upjohn Co | 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
-
1995
- 1995-12-22 FR FR9515379A patent/FR2742751B1/en not_active Expired - Fee Related
-
1996
- 1996-12-04 PE PE1996000871A patent/PE25198A1/en not_active Application Discontinuation
- 1996-12-18 MA MA24431A patent/MA26412A1/en unknown
- 1996-12-19 DK DK96942433T patent/DK0876362T3/en active
- 1996-12-19 UA UA98063216A patent/UA48205C2/en unknown
- 1996-12-19 PT PT96942433T patent/PT876362E/en unknown
- 1996-12-19 ES ES96942433T patent/ES2202490T3/en not_active Expired - Lifetime
- 1996-12-19 ZA ZA9610737A patent/ZA9610737B/en unknown
- 1996-12-19 KR KR10-1998-0704792A patent/KR100500351B1/en not_active IP Right Cessation
- 1996-12-19 IL IL12499496A patent/IL124994A/en not_active IP Right Cessation
- 1996-12-19 AU AU11809/97A patent/AU712597B2/en not_active Ceased
- 1996-12-19 TR TR1998/01179T patent/TR199801179T2/en unknown
- 1996-12-19 NZ NZ324337A patent/NZ324337A/en not_active IP Right Cessation
- 1996-12-19 TW TW085115683A patent/TW371659B/en not_active IP Right Cessation
- 1996-12-19 CA CA002238884A patent/CA2238884C/en not_active Expired - Fee Related
- 1996-12-19 SK SK853-98A patent/SK282835B6/en not_active IP Right Cessation
- 1996-12-19 PL PL96327405A patent/PL189311B1/en not_active IP Right Cessation
- 1996-12-19 EP EP96942433A patent/EP0876362B1/en not_active Expired - Lifetime
- 1996-12-19 WO PCT/FR1996/002031 patent/WO1997023473A1/en active IP Right Grant
- 1996-12-19 CZ CZ19981961A patent/CZ294972B6/en not_active IP Right Cessation
- 1996-12-19 CN CN96199168A patent/CN1103766C/en not_active Expired - Fee Related
- 1996-12-19 AT AT96942433T patent/ATE250593T1/en active
- 1996-12-19 DE DE69630145T patent/DE69630145T2/en not_active Expired - Lifetime
- 1996-12-19 RO RO98-01093A patent/RO116194B1/en unknown
- 1996-12-19 BR BR9612135A patent/BR9612135A/en not_active IP Right Cessation
- 1996-12-19 EA EA199800588A patent/EA001533B1/en not_active IP Right Cessation
- 1996-12-19 HU HU9904046A patent/HU225032B1/en not_active IP Right Cessation
- 1996-12-19 JP JP52336197A patent/JP3953106B2/en not_active Expired - Fee Related
- 1996-12-20 IN IN2893DE1996 patent/IN186768B/en unknown
- 1996-12-20 US US08/771,751 patent/US5728849A/en not_active Expired - Lifetime
- 1996-12-20 AR ARP960105851A patent/AR005197A1/en active IP Right Grant
- 1996-12-20 CO CO96067023A patent/CO4520184A1/en unknown
- 1996-12-20 TN TNTNSN96169A patent/TNSN96169A1/en unknown
- 1996-12-20 MY MYPI96005421A patent/MY113934A/en unknown
- 1996-12-21 DZ DZ960194A patent/DZ2149A1/en active
-
1998
- 1998-06-05 NO NO19982580A patent/NO317358B1/en not_active IP Right Cessation
- 1998-06-11 MX MX9804688A patent/MX9804688A/en not_active IP Right Cessation
- 1998-06-19 OA OA9800087A patent/OA10700A/en unknown
- 1998-06-22 BG BG102569A patent/BG63204B1/en unknown
-
1999
- 1999-07-13 HK HK99102999A patent/HK1017895A1/en not_active IP Right Cessation
-
2000
- 2000-04-10 IN IN421DE2000 patent/IN188470B/en unknown
- 2000-04-10 IN IN419DE2000 patent/IN188680B/en unknown
- 2000-04-10 IN IN420DE2000 patent/IN188469B/en unknown
- 2000-12-02 UY UY24386A patent/UY24386A1/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC |