DE69622527T2 - FORMULA FOR TOPICAL APPLICATION ON THE EYE CONTAINING OLOPATADINE FOR THE TREATMENT OF ALLERGIC EYE DISEASES - Google Patents
FORMULA FOR TOPICAL APPLICATION ON THE EYE CONTAINING OLOPATADINE FOR THE TREATMENT OF ALLERGIC EYE DISEASESInfo
- Publication number
- DE69622527T2 DE69622527T2 DE69622527T DE69622527T DE69622527T2 DE 69622527 T2 DE69622527 T2 DE 69622527T2 DE 69622527 T DE69622527 T DE 69622527T DE 69622527 T DE69622527 T DE 69622527T DE 69622527 T2 DE69622527 T2 DE 69622527T2
- Authority
- DE
- Germany
- Prior art keywords
- eye
- formula
- treatment
- allergic
- topical application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pyrane Compounds (AREA)
Abstract
Topical ophthalmic formulations of the invention contain as an active ingredient 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid or a pharmaceutically acceptable salt thereof. The formulations are useful for treating allergic eye diseases such as allergic conjunctivitis, vernal conjunctivitis, vernal keratoconjunctivitis, and giant papillary conjunctivitis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/469,729 US5641805A (en) | 1995-06-06 | 1995-06-06 | Topical ophthalmic formulations for treating allergic eye diseases |
PCT/US1996/006289 WO1996039147A2 (en) | 1995-06-06 | 1996-05-03 | Topical ophthalmic formulations containing doxepin derivatives for treating allergic eye diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69622527D1 DE69622527D1 (en) | 2002-08-29 |
DE69622527T2 true DE69622527T2 (en) | 2002-12-05 |
Family
ID=23864859
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69622527T Expired - Lifetime DE69622527T2 (en) | 1995-06-06 | 1996-05-03 | FORMULA FOR TOPICAL APPLICATION ON THE EYE CONTAINING OLOPATADINE FOR THE TREATMENT OF ALLERGIC EYE DISEASES |
DE2002199034 Active DE10299034I2 (en) | 1995-06-06 | 1996-05-03 | Formulation for topical use on the eye containing olopatadine for the treatment of allergic eye diseases. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2002199034 Active DE10299034I2 (en) | 1995-06-06 | 1996-05-03 | Formulation for topical use on the eye containing olopatadine for the treatment of allergic eye diseases. |
Country Status (20)
Country | Link |
---|---|
US (1) | US5641805A (en) |
EP (1) | EP0799044B1 (en) |
JP (1) | JP3068858B2 (en) |
KR (1) | KR100202155B1 (en) |
CN (1) | CN1082367C (en) |
AT (1) | ATE220906T1 (en) |
AU (1) | AU698854B2 (en) |
CA (1) | CA2195094C (en) |
DE (2) | DE69622527T2 (en) |
DK (1) | DK0799044T3 (en) |
ES (1) | ES2179198T3 (en) |
FI (1) | FI970489A0 (en) |
LU (1) | LU90969I2 (en) |
MX (1) | MX9701013A (en) |
MY (1) | MY116651A (en) |
NL (1) | NL300101I2 (en) |
NO (1) | NO311637B1 (en) |
PT (1) | PT799044E (en) |
TW (1) | TW438588B (en) |
WO (1) | WO1996039147A2 (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5859000A (en) * | 1995-06-07 | 1999-01-12 | University Of Utah Research Foundation | Method for reducing mast cell mediated allergic reactions |
CA2306393C (en) * | 1998-07-14 | 2008-12-23 | Alcon Laboratories, Inc. | Use of 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid for the manufacture of a medicament for treating non-allergic ophthalmic inflammatory disorders and for the prevention of ocular neovascularization |
US6174914B1 (en) | 1999-06-15 | 2001-01-16 | Alcon Laboratories, Inc. | Method of inhibiting cytokine release from human ocular cells |
EP1187617B1 (en) | 1999-06-18 | 2004-03-03 | Alcon Manufacturing Ltd. | Method for selecting the concentration of an amphipathic antihistamine drug by determining the drug's surface activity rating |
EP1250133B1 (en) | 2000-01-25 | 2005-03-30 | Alcon Inc. | Ophthalmic anti-allergy compositions suitable for use with contact lenses |
DK1282599T3 (en) | 2000-05-19 | 2006-07-31 | Alcon Inc | Disulfide derivatives suitable for the treatment of allergic diseases |
AU5722701A (en) | 2000-05-19 | 2001-12-03 | Alcon Universal Ltd | Aniline disulfide derivatives for treating allergic diseases |
AU2001253807B2 (en) | 2000-05-19 | 2005-02-17 | Alcon, Inc. | Compositions containing a benzamide disulfide derivative for treating allergic diseases |
CA2445269A1 (en) * | 2001-05-03 | 2002-11-14 | Novartis Ag | Anti-ige antibody to treat ocular allergies |
TWI231759B (en) | 2001-06-27 | 2005-05-01 | Alcon Inc | Olopatadine formulations for topical administration |
US7977376B2 (en) * | 2001-06-27 | 2011-07-12 | Novartis Ag | Olopatadine formulations for topical nasal administration |
CN1599625A (en) * | 2001-12-05 | 2005-03-23 | 爱尔康公司 | Use of an h1 antagonist and a safe steroid to treat rhinitis |
US20050209312A1 (en) * | 2004-03-19 | 2005-09-22 | Bausch & Lomb Incorporated | Carboxylic acid derivatives of doxepin formulations preserved with low-irritation preservative |
AU2005259911A1 (en) * | 2004-06-28 | 2006-01-12 | Alcon, Inc. | Topical formulations for treating allergic diseases |
MX2007005845A (en) * | 2004-11-24 | 2007-07-04 | Alcon Inc | Method of delivering nasal spray. |
US8101654B2 (en) * | 2005-07-08 | 2012-01-24 | Senju Pharmaceutical Co., Ltd. | Percutaneously absorptive ophthalmic preparation comprising olopatadine |
ES2594655T3 (en) | 2006-03-31 | 2016-12-21 | Vistakon Pharmaceuticals, Llc | Treatment of eye allergies |
US20080139531A1 (en) * | 2006-12-04 | 2008-06-12 | Alcon Manufacturing Ltd. | Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair |
SI2114367T1 (en) | 2007-02-07 | 2016-01-29 | Novartis Ag | Olopatadine formulations for topical nasal administration |
CA2682730A1 (en) * | 2007-04-11 | 2008-10-23 | Alcon Research, Ltd. | Use of an inhibitor of tnf.alpha. plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis |
US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
CA2698651A1 (en) * | 2007-09-06 | 2009-03-12 | Kyowa Hakko Kirin Co., Ltd. | Eye drop containing dibenz [b,e] oxepin derivative |
US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
IT1397503B1 (en) | 2009-04-21 | 2013-01-16 | F S I Fabbrica Italiana Sint | PROCESS FOR THE PREPARATION OF OLOPATADIN |
JP2012533554A (en) | 2009-07-17 | 2012-12-27 | アルコン リサーチ, リミテッド | Olopatadine nasal spray regimen for children |
WO2011027322A1 (en) | 2009-09-03 | 2011-03-10 | Ranbaxy Laboratories Limited | Extended release dosage form containing olopatadine for oral administration |
KR20120091037A (en) * | 2009-10-01 | 2012-08-17 | 알콘 리서치, 리미티드 | Olopatadine compositions and uses thereof |
TW201206936A (en) | 2010-07-19 | 2012-02-16 | Alcon Res Ltd | Methods and compositions for the treatment of allergy |
TWI544922B (en) | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | High concentration olopatadine ophthalmic composition |
CN103202833A (en) * | 2012-12-25 | 2013-07-17 | 常州市亚邦医药研究所有限公司 | Pharmaceutical composition of olopatadine or salts of olopatadine, and preparation method thereof |
US20150119455A1 (en) * | 2013-10-31 | 2015-04-30 | Nephron Pharmaceuticals Corporation | Formulation |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4370324A (en) * | 1980-09-17 | 1983-01-25 | Bernstein Joel E | Method and composition for treating and preventing irritation of the eyes |
US4923892A (en) * | 1985-08-17 | 1990-05-08 | Burroughs Wellcome Co. | Tricyclic aromatic compounds |
GB8520662D0 (en) * | 1985-08-17 | 1985-09-25 | Wellcome Found | Tricyclic aromatic compounds |
JPS6310784A (en) * | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | Dibenz(b,e)oxepin derivative, antiallergic agent and anti-inflammatory agent |
-
1995
- 1995-06-06 US US08/469,729 patent/US5641805A/en not_active Expired - Lifetime
-
1996
- 1996-05-03 AU AU57261/96A patent/AU698854B2/en not_active Expired
- 1996-05-03 WO PCT/US1996/006289 patent/WO1996039147A2/en active IP Right Grant
- 1996-05-03 AT AT96915500T patent/ATE220906T1/en active
- 1996-05-03 PT PT96915500T patent/PT799044E/en unknown
- 1996-05-03 DE DE69622527T patent/DE69622527T2/en not_active Expired - Lifetime
- 1996-05-03 DK DK96915500T patent/DK0799044T3/en active
- 1996-05-03 MX MX9701013A patent/MX9701013A/en unknown
- 1996-05-03 EP EP96915500A patent/EP0799044B1/en not_active Expired - Lifetime
- 1996-05-03 DE DE2002199034 patent/DE10299034I2/en active Active
- 1996-05-03 ES ES96915500T patent/ES2179198T3/en not_active Expired - Lifetime
- 1996-05-03 CA CA002195094A patent/CA2195094C/en not_active Expired - Lifetime
- 1996-05-03 JP JP9500510A patent/JP3068858B2/en not_active Expired - Lifetime
- 1996-05-03 CN CN96190605A patent/CN1082367C/en not_active Ceased
- 1996-05-03 KR KR1019970700721A patent/KR100202155B1/en active IP Right Review Request
- 1996-05-14 MY MYPI96001818A patent/MY116651A/en unknown
- 1996-06-04 TW TW085106668A patent/TW438588B/en not_active IP Right Cessation
-
1997
- 1997-02-05 FI FI970489A patent/FI970489A0/en unknown
- 1997-02-05 NO NO19970517A patent/NO311637B1/en not_active IP Right Cessation
-
2002
- 2002-09-19 NL NL300101C patent/NL300101I2/en unknown
- 2002-10-02 LU LU90969C patent/LU90969I2/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP0799044B1 (en) | 2002-07-24 |
NL300101I2 (en) | 2003-01-06 |
CN1161000A (en) | 1997-10-01 |
NL300101I1 (en) | 2002-12-02 |
FI970489A (en) | 1997-02-05 |
JPH09510235A (en) | 1997-10-14 |
WO1996039147A2 (en) | 1996-12-12 |
PT799044E (en) | 2002-11-29 |
DE10299034I2 (en) | 2005-07-07 |
JP3068858B2 (en) | 2000-07-24 |
ATE220906T1 (en) | 2002-08-15 |
NO970517D0 (en) | 1997-02-05 |
EP0799044A2 (en) | 1997-10-08 |
FI970489A0 (en) | 1997-02-05 |
NO970517L (en) | 1997-04-03 |
AU698854B2 (en) | 1998-11-12 |
CA2195094A1 (en) | 1996-12-12 |
KR970704452A (en) | 1997-09-06 |
TW438588B (en) | 2001-06-07 |
US5641805A (en) | 1997-06-24 |
WO1996039147A3 (en) | 1997-02-20 |
LU90969I2 (en) | 2002-12-02 |
DE10299034I1 (en) | 2003-01-23 |
CN1082367C (en) | 2002-04-10 |
DE69622527D1 (en) | 2002-08-29 |
MX9701013A (en) | 1997-05-31 |
ES2179198T3 (en) | 2003-01-16 |
NO311637B1 (en) | 2001-12-27 |
AU5726196A (en) | 1996-12-24 |
DK0799044T3 (en) | 2002-10-14 |
KR100202155B1 (en) | 1999-06-15 |
MY116651A (en) | 2004-03-31 |
CA2195094C (en) | 2002-02-26 |
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