DE69621463D1 - METHOD FOR SELECTED PROTECTION OF BACCATINE DERIVATIVES AND THEIR USE FOR THE SYNTHESIS OF TAXANS - Google Patents

METHOD FOR SELECTED PROTECTION OF BACCATINE DERIVATIVES AND THEIR USE FOR THE SYNTHESIS OF TAXANS

Info

Publication number
DE69621463D1
DE69621463D1 DE69621463T DE69621463T DE69621463D1 DE 69621463 D1 DE69621463 D1 DE 69621463D1 DE 69621463 T DE69621463 T DE 69621463T DE 69621463 T DE69621463 T DE 69621463T DE 69621463 D1 DE69621463 D1 DE 69621463D1
Authority
DE
Germany
Prior art keywords
derivatives
taxans
baccatine
synthesis
selected protection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69621463T
Other languages
German (de)
Other versions
DE69621463T2 (en
Inventor
Luc Chanteloup
Bruno Chauveau
Christine Corbin
Robert Dhal
Guen Sonia Le
Arnaud Lamy
Antoine Leze
Jean-Pierre Robin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dEtude et de Recherche en Ingenierie Pharmaceutique SAS SERIPHARM
Original Assignee
Societe dEtude et de Recherche en Ingenierie Pharmaceutique SAS SERIPHARM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe dEtude et de Recherche en Ingenierie Pharmaceutique SAS SERIPHARM filed Critical Societe dEtude et de Recherche en Ingenierie Pharmaceutique SAS SERIPHARM
Publication of DE69621463D1 publication Critical patent/DE69621463D1/en
Application granted granted Critical
Publication of DE69621463T2 publication Critical patent/DE69621463T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

New processes for the selective protection of the 7-position of 7,10-dihydroxytaxane derivatives, using beta-substituted-alkoxycarbonyl groups which are more hindered than 2,2,2-trichloroethoxycarbonyl, and which are capable of being removed by a beta-elimination mechanism, and the new intermediates resulting from these processes. The new intermediates of the invention are useful for preparing taxol and analogs thereof.
DE69621463T 1995-12-27 1996-12-27 METHOD FOR SELECTED PROTECTION OF BACCATINE DERIVATIVES AND THEIR USE FOR THE SYNTHESIS OF TAXANS Expired - Lifetime DE69621463T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9515557A FR2743074B1 (en) 1995-12-27 1995-12-27 METHOD FOR THE SELECTIVE PROTECTION OF BACCATIN DERIVATIVES AND ITS USE IN THE SYNTHESIS OF TAXANES
PCT/FR1996/002097 WO1997024345A1 (en) 1995-12-27 1996-12-27 Method for selective protection of baccatin derivatives and its application to taxane synthesis

Publications (2)

Publication Number Publication Date
DE69621463D1 true DE69621463D1 (en) 2002-07-04
DE69621463T2 DE69621463T2 (en) 2002-11-28

Family

ID=9486008

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69621463T Expired - Lifetime DE69621463T2 (en) 1995-12-27 1996-12-27 METHOD FOR SELECTED PROTECTION OF BACCATINE DERIVATIVES AND THEIR USE FOR THE SYNTHESIS OF TAXANS

Country Status (25)

Country Link
US (1) US6180802B1 (en)
EP (1) EP0889885B1 (en)
JP (1) JP4068663B2 (en)
KR (1) KR100510017B1 (en)
CN (3) CN1090625C (en)
AT (1) ATE218133T1 (en)
AU (1) AU716876B2 (en)
BR (1) BR9612242A (en)
CA (1) CA2238889C (en)
CZ (1) CZ20191998A3 (en)
DE (1) DE69621463T2 (en)
DK (1) DK0889885T3 (en)
ES (1) ES2177825T3 (en)
FR (1) FR2743074B1 (en)
HK (2) HK1044765B (en)
HU (1) HUP0000508A3 (en)
IL (2) IL125049A (en)
NO (1) NO982719D0 (en)
NZ (1) NZ325323A (en)
PL (1) PL327581A1 (en)
PT (1) PT889885E (en)
RU (1) RU2162844C2 (en)
SK (1) SK88498A3 (en)
TR (1) TR199801232T2 (en)
WO (1) WO1997024345A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT875508E (en) * 1997-05-02 2004-02-27 Pharmachemie Bv METHOD FOR THE PREPARATION OF BACATINE III AND ITS DERIVATIVES FROM 10-DECACEACEBACLATIN III
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
CN101663262B (en) 2006-12-01 2014-03-26 百时美施贵宝公司 N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
EP2183234A4 (en) * 2007-08-22 2012-02-29 Canada Inc 6570763 Process for converting 9-dihydro-13-acetylbaccatin iii into docetaxel or paclitaxel
PL388144A1 (en) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate 4-acetoxy-2?-benzoiloxy-5� ,20-epoxy-1, 7�, 10�-trihydroxy-9-oxo-taks-11 -en-13?-yl solvates, a method for their production and application thereof
CN115260130A (en) * 2022-07-07 2022-11-01 上海卓鼎生物技术有限公司 Preparation method of 10-deacetylated paclitaxel

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (en) 1986-07-17 1988-09-23 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF TAXOL AND DESACETYL-10 TAXOL
FR2601675B1 (en) * 1986-07-17 1988-09-23 Rhone Poulenc Sante TAXOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
IL127599A (en) * 1994-01-28 2004-06-01 Upjohn Co Process for preparing isotaxol analogs

Also Published As

Publication number Publication date
KR19990076733A (en) 1999-10-15
RU2162844C2 (en) 2001-02-10
IL138769A (en) 2006-04-10
CA2238889C (en) 2008-06-10
CN1206412A (en) 1999-01-27
NZ325323A (en) 1999-11-29
DK0889885T3 (en) 2002-09-16
HK1047099A1 (en) 2003-02-07
CN1243745C (en) 2006-03-01
TR199801232T2 (en) 1998-09-21
HUP0000508A3 (en) 2001-05-28
FR2743074B1 (en) 1998-03-27
HK1044765A1 (en) 2002-11-01
CN1244567C (en) 2006-03-08
HUP0000508A2 (en) 2000-07-28
FR2743074A1 (en) 1997-07-04
NO982719L (en) 1998-06-12
JP4068663B2 (en) 2008-03-26
CN1356325A (en) 2002-07-03
HK1047099B (en) 2006-09-29
ATE218133T1 (en) 2002-06-15
HK1044765B (en) 2006-09-29
PL327581A1 (en) 1998-12-21
CN1356326A (en) 2002-07-03
AU1381597A (en) 1997-07-28
DE69621463T2 (en) 2002-11-28
EP0889885B1 (en) 2002-05-29
AU716876B2 (en) 2000-03-09
SK88498A3 (en) 1998-11-04
WO1997024345A1 (en) 1997-07-10
NO982719D0 (en) 1998-06-12
US6180802B1 (en) 2001-01-30
PT889885E (en) 2002-10-31
CA2238889A1 (en) 1997-07-10
IL125049A0 (en) 1999-01-26
JP2000502696A (en) 2000-03-07
IL125049A (en) 2003-10-31
BR9612242A (en) 1999-07-13
CN1090625C (en) 2002-09-11
EP0889885A1 (en) 1999-01-13
ES2177825T3 (en) 2002-12-16
CZ20191998A3 (en) 1998-09-16
KR100510017B1 (en) 2005-12-16

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Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC