DE69606677D1 - A 2-cyano-3-hydroxy-propenamide derivative containing a trifluoromethylsulfonylphenyl or trifluoromethylsulfinylphenyl group, processes for their preparation, their use as medicaments and pharmaceutical compositions containing them - Google Patents

A 2-cyano-3-hydroxy-propenamide derivative containing a trifluoromethylsulfonylphenyl or trifluoromethylsulfinylphenyl group, processes for their preparation, their use as medicaments and pharmaceutical compositions containing them

Info

Publication number
DE69606677D1
DE69606677D1 DE69606677T DE69606677T DE69606677D1 DE 69606677 D1 DE69606677 D1 DE 69606677D1 DE 69606677 T DE69606677 T DE 69606677T DE 69606677 T DE69606677 T DE 69606677T DE 69606677 D1 DE69606677 D1 DE 69606677D1
Authority
DE
Germany
Prior art keywords
cyano
hydroxy
trifluoromethylsulfonylphenyl
medicaments
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69606677T
Other languages
German (de)
Other versions
DE69606677T2 (en
Inventor
David Paul Kay
Elizabert Anne Kuo
Richard Alexander Williamson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Hoechst Marion Roussel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel filed Critical Hoechst Marion Roussel
Application granted granted Critical
Publication of DE69606677D1 publication Critical patent/DE69606677D1/en
Publication of DE69606677T2 publication Critical patent/DE69606677T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C07C317/40—Y being a hydrogen or a carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Trifluoromethyl -sulphonyl or -sulphinyl phenyl 2-cyano-3-hydroxy propenamide derivs. of formula (I) and their salts are new. R1 = cyclopropyl or CH2CH=CH2; R2 = S(O)n(CF2)xCF3; n = 1 or 2; x = 0 or 1; R3 = H or 1-3C alkyl, m = 0 or 1. Also claimed are the intermediates of formula (IV).
DE69606677T 1995-10-02 1996-10-01 A 2-cyano-3-hydroxy-propenamide derivative containing a trifluoromethylsulfonylphenyl or trifluoromethylsulfinylphenyl group, processes for their preparation, their use as medicaments and pharmaceutical compositions containing them Expired - Fee Related DE69606677T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9520092.9A GB9520092D0 (en) 1995-10-02 1995-10-02 Chemical compounds

Publications (2)

Publication Number Publication Date
DE69606677D1 true DE69606677D1 (en) 2000-03-23
DE69606677T2 DE69606677T2 (en) 2000-08-17

Family

ID=10781638

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69606677T Expired - Fee Related DE69606677T2 (en) 1995-10-02 1996-10-01 A 2-cyano-3-hydroxy-propenamide derivative containing a trifluoromethylsulfonylphenyl or trifluoromethylsulfinylphenyl group, processes for their preparation, their use as medicaments and pharmaceutical compositions containing them

Country Status (10)

Country Link
US (1) US5693844A (en)
EP (1) EP0767167B1 (en)
JP (1) JPH09132559A (en)
AT (1) ATE189810T1 (en)
DE (1) DE69606677T2 (en)
DK (1) DK0767167T3 (en)
ES (1) ES2143159T3 (en)
GB (1) GB9520092D0 (en)
GR (1) GR3033175T3 (en)
PT (1) PT767167E (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010079782A (en) 1998-09-11 2001-08-22 에가시라 구니오 Benzene derivatives and medicinal use thereof
US8686048B2 (en) 2010-05-06 2014-04-01 Rhizen Pharmaceuticals Sa Immunomodulator and anti-inflammatory compounds
US20140031383A1 (en) 2011-02-08 2014-01-30 Dana-Farber Cancer Institute, Inc. Methods for treatment of melanoma
JP2016537360A (en) 2013-11-22 2016-12-01 ジェンザイム・コーポレーション Novel methods for treating neurodegenerative diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1116382B (en) * 1977-11-30 1986-02-10 Sigma Tau Ind Farmaceuti INDUSTRIAL PREPARATION METHOD FOR ISOBUTYRIC RS-BETA-BENZOYLAMINE ACID
IT1097280B (en) * 1978-06-26 1985-08-31 Montedison Spa BISMETINIC PIGMENTS
US4710514A (en) * 1982-05-04 1987-12-01 Sumitomo Chemical Company, Limited Fungicidal carbamates and thiolcarbamates
US4946867A (en) * 1987-09-07 1990-08-07 Sumitomo Chemical Company, Limited Cyanoacetamide derivative, and plant disease protectant comprising the same as an active ingredient
US5494911A (en) * 1990-05-18 1996-02-27 Hoechst Aktiengesellschaft Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use
IL99811A (en) * 1990-10-30 1996-03-31 Roussel Uclaf 3-cycloalkyl-propanamides their tautomer forms and their salts preparation process and compositions containing them
IL102790A (en) * 1991-09-17 1996-01-31 Roussel Uclaf 3-Cycloalkyl-prop-2- enamide derivatives
GB9200275D0 (en) * 1992-01-08 1992-02-26 Roussel Lab Ltd Chemical compounds
GB9313365D0 (en) * 1993-06-29 1993-08-11 Roussel Lab Ltd Chemical compounds

Also Published As

Publication number Publication date
DK0767167T3 (en) 2000-07-24
DE69606677T2 (en) 2000-08-17
ATE189810T1 (en) 2000-03-15
EP0767167B1 (en) 2000-02-16
GR3033175T3 (en) 2000-08-31
US5693844A (en) 1997-12-02
JPH09132559A (en) 1997-05-20
ES2143159T3 (en) 2000-05-01
GB9520092D0 (en) 1995-12-06
EP0767167A1 (en) 1997-04-09
PT767167E (en) 2000-06-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMA S.A., ANTONY CEDEX, FR

8339 Ceased/non-payment of the annual fee