DE69604541D1 - DTPA derivatives modified with non-ester formation and process for their preparation - Google Patents

DTPA derivatives modified with non-ester formation and process for their preparation

Info

Publication number
DE69604541D1
DE69604541D1 DE69604541T DE69604541T DE69604541D1 DE 69604541 D1 DE69604541 D1 DE 69604541D1 DE 69604541 T DE69604541 T DE 69604541T DE 69604541 T DE69604541 T DE 69604541T DE 69604541 D1 DE69604541 D1 DE 69604541D1
Authority
DE
Germany
Prior art keywords
preparation
ester formation
derivatives modified
dtpa derivatives
dtpa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69604541T
Other languages
German (de)
Other versions
DE69604541T2 (en
Inventor
Yoshinori Yamamoto
Hisao Nemoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tohoku University NUC
Original Assignee
Tohoku University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tohoku University NUC filed Critical Tohoku University NUC
Application granted granted Critical
Publication of DE69604541D1 publication Critical patent/DE69604541D1/en
Publication of DE69604541T2 publication Critical patent/DE69604541T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A61K51/048—DTPA (diethylenetriamine tetraacetic acid)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
DE69604541T 1995-07-21 1996-07-18 DTPA derivatives modified with non-ester formation and processes for their preparation Expired - Fee Related DE69604541T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7185306A JP2759627B2 (en) 1995-07-21 1995-07-21 Non-ester bondable DTPA derivative and method for producing the same

Publications (2)

Publication Number Publication Date
DE69604541D1 true DE69604541D1 (en) 1999-11-11
DE69604541T2 DE69604541T2 (en) 2000-02-17

Family

ID=16168555

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69604541T Expired - Fee Related DE69604541T2 (en) 1995-07-21 1996-07-18 DTPA derivatives modified with non-ester formation and processes for their preparation

Country Status (5)

Country Link
US (1) US5780670A (en)
EP (1) EP0754677B1 (en)
JP (1) JP2759627B2 (en)
AU (1) AU686950B2 (en)
DE (1) DE69604541T2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7405320B2 (en) 1998-06-22 2008-07-29 Immunomedics, Inc. Therapeutic and diagnostic conjugates for use with multispecific antibodies
JP5004438B2 (en) * 2005-06-09 2012-08-22 行政院原子能委員会核能研究所 Method for producing DTPA derivative
US8030358B2 (en) 2007-10-29 2011-10-04 University Of Kentucky Research Foundation Methods and pharmaceutical compositions for decorporation of radioactive compounds
EP2489655A4 (en) * 2009-10-15 2014-03-12 Univ Tokushima Process for preparation of diethylenetriaminepentaacetic acid derivatives, and diethylenetriaminepentaacetic acid derivatives
WO2013109323A2 (en) * 2011-10-21 2013-07-25 The University Of North Carolina At Chapel Hill Topical dtpa prodrug formulations and methods of using the same
WO2013180730A1 (en) * 2012-06-01 2013-12-05 Lawrence Lowell Jeffry Large-scale high yield manufacturing process for high purity pentaalkyl esters of dtpa
JP6660735B2 (en) 2012-11-26 2020-03-11 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル DTPA diethyl ester, compositions thereof and methods of using the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3062719A (en) * 1959-10-19 1962-11-06 Geigy Chem Corp Trisodium calcium diethylenetriaminepentaacetic acid, compositions containing the same, and the use thereof
JPS5745335A (en) * 1980-09-02 1982-03-15 Mitsui Eng & Shipbuild Co Ltd Heating fluidized bed reactor
US5011925A (en) * 1989-03-09 1991-04-30 Mallinckrodt, Inc. Morpholinoamido EDTA derivatives
DE3922005A1 (en) * 1989-06-30 1991-01-10 Schering Ag DERIVATIVED DTPA COMPLEXES, PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS, THEIR USE AND METHOD FOR THE PRODUCTION THEREOF
CA2116867C (en) * 1992-07-03 2004-04-27 The Green Cross Corporation Novel chelating agent, complex compound of said chelating agent and metallic atom, and diagnostic agent comprising same

Also Published As

Publication number Publication date
JP2759627B2 (en) 1998-05-28
EP0754677B1 (en) 1999-10-06
DE69604541T2 (en) 2000-02-17
AU686950B2 (en) 1998-02-12
JPH0931037A (en) 1997-02-04
US5780670A (en) 1998-07-14
AU6057396A (en) 1997-01-30
EP0754677A1 (en) 1997-01-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee