DE69604541D1 - DTPA derivatives modified with non-ester formation and process for their preparation - Google Patents
DTPA derivatives modified with non-ester formation and process for their preparationInfo
- Publication number
- DE69604541D1 DE69604541D1 DE69604541T DE69604541T DE69604541D1 DE 69604541 D1 DE69604541 D1 DE 69604541D1 DE 69604541 T DE69604541 T DE 69604541T DE 69604541 T DE69604541 T DE 69604541T DE 69604541 D1 DE69604541 D1 DE 69604541D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- ester formation
- derivatives modified
- dtpa derivatives
- dtpa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical class OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
- A61K51/048—DTPA (diethylenetriamine tetraacetic acid)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7185306A JP2759627B2 (en) | 1995-07-21 | 1995-07-21 | Non-ester bondable DTPA derivative and method for producing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69604541D1 true DE69604541D1 (en) | 1999-11-11 |
DE69604541T2 DE69604541T2 (en) | 2000-02-17 |
Family
ID=16168555
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69604541T Expired - Fee Related DE69604541T2 (en) | 1995-07-21 | 1996-07-18 | DTPA derivatives modified with non-ester formation and processes for their preparation |
Country Status (5)
Country | Link |
---|---|
US (1) | US5780670A (en) |
EP (1) | EP0754677B1 (en) |
JP (1) | JP2759627B2 (en) |
AU (1) | AU686950B2 (en) |
DE (1) | DE69604541T2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7405320B2 (en) | 1998-06-22 | 2008-07-29 | Immunomedics, Inc. | Therapeutic and diagnostic conjugates for use with multispecific antibodies |
JP5004438B2 (en) * | 2005-06-09 | 2012-08-22 | 行政院原子能委員会核能研究所 | Method for producing DTPA derivative |
US8030358B2 (en) | 2007-10-29 | 2011-10-04 | University Of Kentucky Research Foundation | Methods and pharmaceutical compositions for decorporation of radioactive compounds |
US8487126B2 (en) | 2009-10-15 | 2013-07-16 | The University Of Tokushima | Process for preparation of diethylenetriaminepentaacetic acid derivative, and diethylenetriaminepentaacetic acid derivative |
WO2013109323A2 (en) * | 2011-10-21 | 2013-07-25 | The University Of North Carolina At Chapel Hill | Topical dtpa prodrug formulations and methods of using the same |
WO2013180730A1 (en) * | 2012-06-01 | 2013-12-05 | Lawrence Lowell Jeffry | Large-scale high yield manufacturing process for high purity pentaalkyl esters of dtpa |
ES2890650T3 (en) | 2012-11-26 | 2022-01-21 | Univ North Carolina Chapel Hill | Di-ethyl esters of DTPA, compositions thereof, and methods of using the same |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3062719A (en) * | 1959-10-19 | 1962-11-06 | Geigy Chem Corp | Trisodium calcium diethylenetriaminepentaacetic acid, compositions containing the same, and the use thereof |
JPS5745335A (en) * | 1980-09-02 | 1982-03-15 | Mitsui Eng & Shipbuild Co Ltd | Heating fluidized bed reactor |
US5011925A (en) * | 1989-03-09 | 1991-04-30 | Mallinckrodt, Inc. | Morpholinoamido EDTA derivatives |
DE3922005A1 (en) * | 1989-06-30 | 1991-01-10 | Schering Ag | DERIVATIVED DTPA COMPLEXES, PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS, THEIR USE AND METHOD FOR THE PRODUCTION THEREOF |
WO1994001393A1 (en) * | 1992-07-03 | 1994-01-20 | The Green Cross Corporation | Novel chelating agent, complex compound composed of said agent and metallic atom, and diagnostic agent containing said compound |
-
1995
- 1995-07-21 JP JP7185306A patent/JP2759627B2/en not_active Expired - Lifetime
-
1996
- 1996-07-16 US US08/680,611 patent/US5780670A/en not_active Expired - Fee Related
- 1996-07-18 DE DE69604541T patent/DE69604541T2/en not_active Expired - Fee Related
- 1996-07-18 EP EP96111604A patent/EP0754677B1/en not_active Expired - Lifetime
- 1996-07-19 AU AU60573/96A patent/AU686950B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP0754677B1 (en) | 1999-10-06 |
US5780670A (en) | 1998-07-14 |
JPH0931037A (en) | 1997-02-04 |
AU686950B2 (en) | 1998-02-12 |
EP0754677A1 (en) | 1997-01-22 |
DE69604541T2 (en) | 2000-02-17 |
AU6057396A (en) | 1997-01-30 |
JP2759627B2 (en) | 1998-05-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |