DE69603163D1 - VERFAHREN ZUR HERSTELLUNG VON HIV PROTEASE INHIBITOR AUSGEHEND VON (2S)-4-PICOLYL-2-PIPERAZIN-t-BUTYLCARBOXAMID - Google Patents
VERFAHREN ZUR HERSTELLUNG VON HIV PROTEASE INHIBITOR AUSGEHEND VON (2S)-4-PICOLYL-2-PIPERAZIN-t-BUTYLCARBOXAMIDInfo
- Publication number
- DE69603163D1 DE69603163D1 DE69603163T DE69603163T DE69603163D1 DE 69603163 D1 DE69603163 D1 DE 69603163D1 DE 69603163 T DE69603163 T DE 69603163T DE 69603163 T DE69603163 T DE 69603163T DE 69603163 D1 DE69603163 D1 DE 69603163D1
- Authority
- DE
- Germany
- Prior art keywords
- butylcarboxamide
- picolyl
- piperazine
- protease inhibitor
- hiv protease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/404,798 US5618937A (en) | 1995-03-15 | 1995-03-15 | Process to make HIV protease inhibitor from (2S)-4-picolyl-2-piperazine-t-butylcarboxamide |
| PCT/US1996/002556 WO1996028439A1 (en) | 1995-03-15 | 1996-03-11 | PROCESS TO MAKE HIV PROTEASE INHIBITOR FROM 2(S)-4-PICOLYL-2-PIPERAZINE-t-BUTYLCARBOXAMIDE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69603163D1 true DE69603163D1 (de) | 1999-08-12 |
Family
ID=23601087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69603163T Expired - Lifetime DE69603163D1 (de) | 1995-03-15 | 1996-03-11 | VERFAHREN ZUR HERSTELLUNG VON HIV PROTEASE INHIBITOR AUSGEHEND VON (2S)-4-PICOLYL-2-PIPERAZIN-t-BUTYLCARBOXAMID |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5618937A (de) |
| EP (1) | EP0815101B1 (de) |
| CN (1) | CN1100054C (de) |
| AR (1) | AR002712A1 (de) |
| AT (1) | ATE181916T1 (de) |
| AU (1) | AU5173896A (de) |
| BR (1) | BR9607376A (de) |
| CZ (1) | CZ292549B6 (de) |
| DE (1) | DE69603163D1 (de) |
| EA (1) | EA000178B1 (de) |
| HR (1) | HRP960114B1 (de) |
| SK (1) | SK282021B6 (de) |
| TW (1) | TW332205B (de) |
| UA (1) | UA49826C2 (de) |
| WO (1) | WO1996028439A1 (de) |
| YU (1) | YU15496A (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5700364A (en) * | 1995-10-30 | 1997-12-23 | Merck & Co., Inc. | Electrochemical oxidation |
| NL1006305C2 (nl) * | 1997-06-13 | 1998-12-15 | Dsm Nv | Werkwijze voor de bereiding van (1S,2R)-1-amino-2-indanol-(R,R)-tartraat methanol solvaat. |
| US7199240B2 (en) * | 2002-12-11 | 2007-04-03 | Merck & Co., Inc. | Reductive alkylation of saturated cyclic amines |
| US10620330B2 (en) | 2013-03-19 | 2020-04-14 | Westerngeco L.L.C. | Estimating translational data |
| CN110835405B (zh) * | 2019-11-28 | 2020-09-15 | 安阳师范学院 | 用于肿瘤检测的高分子生物传感器及制备方法及应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169952A (en) * | 1991-07-02 | 1992-12-08 | Merck & Co., Inc. | Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides |
| US5413999A (en) * | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
| ATE163926T1 (de) * | 1991-11-08 | 1998-03-15 | Merck & Co Inc | Hiv-protease-inhibitoren verwendbar in der aids- behandlung |
| MX9308016A (es) * | 1992-12-22 | 1994-08-31 | Lilly Co Eli | Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene. |
| US5463067A (en) * | 1993-07-16 | 1995-10-31 | Merck & Co., Inc. | Process for making HIV protease inhibitors |
| TW472047B (en) * | 1994-02-04 | 2002-01-11 | Merck & Co Inc | Process for making HIV protease inhibitors |
| US5420353A (en) * | 1994-03-11 | 1995-05-30 | Merck & Co., Inc. | Regiospecific process to make cis-1-amino-2-alkanol from epoxide |
| US5449830A (en) * | 1994-03-11 | 1995-09-12 | Marck & Co., Inc. | Regiospecific processes to make CIS-1-Amino-2-Alkanol from Diol or Halohydrin |
-
1995
- 1995-03-15 US US08/404,798 patent/US5618937A/en not_active Expired - Fee Related
-
1996
- 1996-03-05 AR ARP960101629A patent/AR002712A1/es unknown
- 1996-03-06 TW TW085102721A patent/TW332205B/zh active
- 1996-03-11 AT AT96908523T patent/ATE181916T1/de not_active IP Right Cessation
- 1996-03-11 CZ CZ19972860A patent/CZ292549B6/cs not_active IP Right Cessation
- 1996-03-11 AU AU51738/96A patent/AU5173896A/en not_active Abandoned
- 1996-03-11 SK SK1225-97A patent/SK282021B6/sk unknown
- 1996-03-11 DE DE69603163T patent/DE69603163D1/de not_active Expired - Lifetime
- 1996-03-11 WO PCT/US1996/002556 patent/WO1996028439A1/en active IP Right Grant
- 1996-03-11 BR BR9607376A patent/BR9607376A/pt not_active Application Discontinuation
- 1996-03-11 EA EA199700235A patent/EA000178B1/ru not_active IP Right Cessation
- 1996-03-11 CN CN96193730A patent/CN1100054C/zh not_active Expired - Fee Related
- 1996-03-11 HR HR08/404,798A patent/HRP960114B1/xx not_active IP Right Cessation
- 1996-03-11 EP EP96908523A patent/EP0815101B1/de not_active Expired - Lifetime
- 1996-03-15 YU YU15496A patent/YU15496A/sh unknown
- 1996-11-03 UA UA97105014A patent/UA49826C2/uk unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ292549B6 (cs) | 2003-10-15 |
| CN1183779A (zh) | 1998-06-03 |
| US5618937A (en) | 1997-04-08 |
| TW332205B (en) | 1998-05-21 |
| HRP960114A2 (en) | 1997-10-31 |
| UA49826C2 (uk) | 2002-10-15 |
| YU15496A (sh) | 1999-03-04 |
| HRP960114B1 (en) | 2000-02-29 |
| SK282021B6 (sk) | 2001-10-08 |
| ATE181916T1 (de) | 1999-07-15 |
| WO1996028439A1 (en) | 1996-09-19 |
| EP0815101A1 (de) | 1998-01-07 |
| CZ286097A3 (cs) | 1998-02-18 |
| AR002712A1 (es) | 1998-04-29 |
| EP0815101B1 (de) | 1999-07-07 |
| AU5173896A (en) | 1996-10-02 |
| CN1100054C (zh) | 2003-01-29 |
| EA199700235A1 (ru) | 1998-04-30 |
| BR9607376A (pt) | 1997-12-30 |
| SK122597A3 (en) | 1998-02-04 |
| EA000178B1 (ru) | 1998-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |