DE69528838T2 - IMPROVED, IBUPROFEN AND CODEIN-CONTAINING PHARMACEUTICAL COMPOSITIONS - Google Patents

IMPROVED, IBUPROFEN AND CODEIN-CONTAINING PHARMACEUTICAL COMPOSITIONS

Info

Publication number
DE69528838T2
DE69528838T2 DE69528838T DE69528838T DE69528838T2 DE 69528838 T2 DE69528838 T2 DE 69528838T2 DE 69528838 T DE69528838 T DE 69528838T DE 69528838 T DE69528838 T DE 69528838T DE 69528838 T2 DE69528838 T2 DE 69528838T2
Authority
DE
Germany
Prior art keywords
ibuprofen
codein
improved
pharmaceutical compositions
containing pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69528838T
Other languages
German (de)
Other versions
DE69528838D1 (en
Inventor
Brian Holmes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9417041A external-priority patent/GB9417041D0/en
Priority claimed from GB9419921A external-priority patent/GB9419921D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of DE69528838D1 publication Critical patent/DE69528838D1/en
Application granted granted Critical
Publication of DE69528838T2 publication Critical patent/DE69528838T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Formulations of ibuprofen and codeine (or a pharmaceutically acceptable salt of either of them) include a carrier comprising a disintegrant, diluent, and a lubricant substantially free from stearic acid and stearate ions and selected from hydrogenated vegetable oils. Preferred formulations are directly-compressed tablets which are useful for treating pain and inflammation.
DE69528838T 1994-08-23 1995-08-16 IMPROVED, IBUPROFEN AND CODEIN-CONTAINING PHARMACEUTICAL COMPOSITIONS Expired - Lifetime DE69528838T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9417041A GB9417041D0 (en) 1994-08-23 1994-08-23 Improved formulations
GB9419921A GB9419921D0 (en) 1994-10-04 1994-10-04 Improved formulations
PCT/GB1995/001947 WO1996005834A1 (en) 1994-08-23 1995-08-16 Improved pharmaceutical formulations containing ibuprofen and codeine

Publications (2)

Publication Number Publication Date
DE69528838D1 DE69528838D1 (en) 2002-12-19
DE69528838T2 true DE69528838T2 (en) 2003-07-10

Family

ID=26305507

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528838T Expired - Lifetime DE69528838T2 (en) 1994-08-23 1995-08-16 IMPROVED, IBUPROFEN AND CODEIN-CONTAINING PHARMACEUTICAL COMPOSITIONS

Country Status (24)

Country Link
EP (1) EP0777477B1 (en)
JP (1) JP3874793B2 (en)
KR (1) KR100397082B1 (en)
CN (1) CN1083265C (en)
AT (1) ATE227574T1 (en)
AU (1) AU699224B2 (en)
BG (1) BG63329B1 (en)
BR (1) BR9508760A (en)
CA (1) CA2156768A1 (en)
CZ (1) CZ287558B6 (en)
DE (1) DE69528838T2 (en)
DK (1) DK0777477T3 (en)
ES (1) ES2187566T3 (en)
HU (1) HU227759B1 (en)
MX (1) MX9701390A (en)
NO (1) NO322200B1 (en)
NZ (1) NZ291223A (en)
PL (1) PL181215B1 (en)
PT (1) PT777477E (en)
RU (1) RU2140782C1 (en)
SK (1) SK282183B6 (en)
TW (1) TW493984B (en)
UA (1) UA42781C2 (en)
WO (1) WO1996005834A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6608073B1 (en) 1998-10-14 2003-08-19 New Millennium Pharmaceutical Research, Inc. Intranasal codeine for the rapid suppression of cough and rapid relief of pain
US6368618B1 (en) 1999-07-01 2002-04-09 The University Of Georgia Research Foundation, Inc. Composition and method for enhanced transdermal absorption of nonsteroidal anti-inflammatory drugs
JP2001253826A (en) * 2000-03-09 2001-09-18 Maruzen Pharmaceut Co Ltd Internal medicine
US7183410B2 (en) 2001-08-02 2007-02-27 Bidachem S.P.A. Stable polymorph of flibanserin
US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
UA78974C2 (en) 2001-10-20 2007-05-10 Boehringer Ingelheim Pharma Use of flibanserin for treating disorders of sexual desire
US20040253311A1 (en) * 2002-12-18 2004-12-16 Roger Berlin Multi-layer tablet comprising non-steroidal anti-inflammatory drugs, decongestants and non-sedating antihist amines
EP1912650B8 (en) 2005-08-03 2017-10-18 Sprout Pharmaceuticals, Inc. Use of flibanserin in the treatment of obesity
US7923449B2 (en) 2005-10-29 2011-04-12 Boehringer Ingelheim International Gmbh Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders
WO2007069033A2 (en) * 2005-12-12 2007-06-21 Adcock Ingram Limited Pharmaceutical compositions comprising dexibuprofen, an opiate analgesic and paracetamol
DE602007004615D1 (en) 2006-06-30 2010-03-18 Boehringer Ingelheim Pharma FLIBANSERIN FOR THE TREATMENT OF HARNINE INCONTINENCE AND ASSOCIATED DISEASES
WO2008007426A1 (en) * 2006-07-12 2008-01-17 Aska Pharmaceutical Co., Ltd. Analgesic agent
BRPI0716439B8 (en) 2006-08-14 2021-05-25 Boehringer Ingelheim Int pharmaceutical delivery systems comprising flibanserin, process for preparation and use thereof
JP5220746B2 (en) 2006-08-25 2013-06-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Controlled release system and manufacturing method thereof
KR20090065513A (en) * 2006-10-05 2009-06-22 코와 가부시키가이샤 Solid preparation comprising ibuprofen and tranexamic acid
UY31335A1 (en) 2007-09-12 2009-04-30 VASOMOTOR SYMPTOMS TREATMENT
DK2279731T3 (en) 2008-04-23 2013-03-18 Farmasierra Mfg S L Improved pharmaceutical composition containing ibuprofen and codeine
ES2365961B1 (en) * 2010-03-30 2013-01-24 Farmasierra Manufacturing S.L. PHARMACEUTICAL FORMULATION BASED ON IBUPROFEN AND IMPROVED STABILITY CODEINE.
KR101317809B1 (en) 2011-06-07 2013-10-16 한미약품 주식회사 Pharmaceutical composition comprising amide derivative inhibiting the growth of cancer cell and non-metalic salt lubricant
KR20140096571A (en) 2013-01-28 2014-08-06 한미약품 주식회사 Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one
EP3185855B1 (en) 2014-08-28 2022-09-07 Sanofi-Aventis Deutschland GmbH Film coated tablet for the treatment of acute pain
CN105395508B (en) * 2015-12-14 2018-06-29 西南药业股份有限公司 A kind of ibuprofen and codeine compound preparation and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4571400A (en) * 1984-12-18 1986-02-18 Belleview Pharmaceutical, Inc. Dihydrocodeine/ibuprofen pharmaceutical compositions and method
GB8905815D0 (en) * 1989-03-14 1989-04-26 Beecham Group Plc Medicament
GB9121204D0 (en) * 1991-10-04 1991-11-20 Euro Celtique Sa Medicament

Also Published As

Publication number Publication date
HU227759B1 (en) 2012-02-28
BG63329B1 (en) 2001-10-31
AU699224B2 (en) 1998-11-26
ATE227574T1 (en) 2002-11-15
NO970782L (en) 1997-02-20
HUT77385A (en) 1998-04-28
CZ287558B6 (en) 2000-12-13
DE69528838D1 (en) 2002-12-19
SK282183B6 (en) 2001-11-06
PL181215B1 (en) 2001-06-29
UA42781C2 (en) 2001-11-15
TW493984B (en) 2002-07-11
PL318807A1 (en) 1997-07-07
DK0777477T3 (en) 2003-03-17
CA2156768A1 (en) 1996-02-24
WO1996005834A1 (en) 1996-02-29
JP3874793B2 (en) 2007-01-31
CN1083265C (en) 2002-04-24
SK23697A3 (en) 1997-08-06
CZ54697A3 (en) 1997-12-17
NO970782D0 (en) 1997-02-20
PT777477E (en) 2003-03-31
KR100397082B1 (en) 2004-02-11
AU3228995A (en) 1996-03-14
RU2140782C1 (en) 1999-11-10
KR970705389A (en) 1997-10-09
EP0777477A1 (en) 1997-06-11
BR9508760A (en) 1998-01-13
ES2187566T3 (en) 2003-06-16
BG101252A (en) 1998-02-27
NO322200B1 (en) 2006-08-28
NZ291223A (en) 1998-12-23
CN1159754A (en) 1997-09-17
EP0777477B1 (en) 2002-11-13
JPH10504557A (en) 1998-05-06
MX9701390A (en) 1998-06-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition