DE69528527T2 - DIAGNOSTIC METHODS AND COMPOSITIONS RELATING TO PROTEOGLYCAN PROTEINS OF CARTILAGE GROWING - Google Patents

DIAGNOSTIC METHODS AND COMPOSITIONS RELATING TO PROTEOGLYCAN PROTEINS OF CARTILAGE GROWING

Info

Publication number
DE69528527T2
DE69528527T2 DE69528527T DE69528527T DE69528527T2 DE 69528527 T2 DE69528527 T2 DE 69528527T2 DE 69528527 T DE69528527 T DE 69528527T DE 69528527 T DE69528527 T DE 69528527T DE 69528527 T2 DE69528527 T2 DE 69528527T2
Authority
DE
Germany
Prior art keywords
diagnostic methods
cartilage
compositions relating
growing
proteoglycan proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69528527T
Other languages
German (de)
Other versions
DE69528527D1 (en
Inventor
Amanda Jane Fosang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Melbourne
Original Assignee
University of Melbourne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Melbourne filed Critical University of Melbourne
Application granted granted Critical
Publication of DE69528527D1 publication Critical patent/DE69528527D1/en
Publication of DE69528527T2 publication Critical patent/DE69528527T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Abstract

This invention relates to methods and compositions for early diagnosis, monitoring and treatment of cartilage degenerative conditions, including forms of arthritis and arthropathy, using an antibody which recognizes a peptide comprising the sequence FFGVG... generated by cleavage of cartilage aggrecan at the site N341-F342.
DE69528527T 1994-07-07 1995-06-30 DIAGNOSTIC METHODS AND COMPOSITIONS RELATING TO PROTEOGLYCAN PROTEINS OF CARTILAGE GROWING Expired - Lifetime DE69528527T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPM6668A AUPM666894A0 (en) 1994-07-07 1994-07-07 Diagnostic methods and compositions
PCT/AU1995/000395 WO1996001847A1 (en) 1994-07-07 1995-06-30 Diagnostic methods and compositions relating to the proteoglycan proteins of cartilage breakdown

Publications (2)

Publication Number Publication Date
DE69528527D1 DE69528527D1 (en) 2002-11-14
DE69528527T2 true DE69528527T2 (en) 2003-06-26

Family

ID=3781236

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528527T Expired - Lifetime DE69528527T2 (en) 1994-07-07 1995-06-30 DIAGNOSTIC METHODS AND COMPOSITIONS RELATING TO PROTEOGLYCAN PROTEINS OF CARTILAGE GROWING

Country Status (8)

Country Link
EP (1) EP0769025B1 (en)
JP (1) JPH10502807A (en)
AT (1) ATE225807T1 (en)
AU (1) AUPM666894A0 (en)
CA (1) CA2194352C (en)
DE (1) DE69528527T2 (en)
DK (1) DK0769025T3 (en)
WO (1) WO1996001847A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4189033B2 (en) 1996-08-15 2008-12-03 ノバルティス アクチエンゲゼルシャフト Quantitative arthritic condition assay
CA2296766C (en) 1997-07-25 2010-03-16 Du Pont Pharmaceuticals Company Aggrecan degrading metallo proteases
WO2000005256A1 (en) * 1998-07-24 2000-02-03 Du Pont Pharmaceuticals Company Assays and peptide substrate for determining aggrecan degrading metallo protease activity
SE9904236D0 (en) 1999-11-22 1999-11-22 Ana Mar Diagnostics Ab Immunoassay
CA2540586A1 (en) * 2003-10-01 2005-04-21 Optimer Pharmaceuticals, Inc. Treatment of a condition in a mammal with administration of aminosugar and uses thereof
WO2013137302A1 (en) 2012-03-13 2013-09-19 国立大学法人 岡山大学 Lysine oligomer derivative and cartilage tissue marker made thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387504A (en) * 1992-09-30 1995-02-07 Merck & Co., Inc. Monospecific antibodies and assay system for detecting stromelysin cleavage products

Also Published As

Publication number Publication date
DK0769025T3 (en) 2003-02-10
EP0769025B1 (en) 2002-10-09
ATE225807T1 (en) 2002-10-15
CA2194352C (en) 2007-01-09
EP0769025A4 (en) 1999-06-16
CA2194352A1 (en) 1996-01-25
EP0769025A1 (en) 1997-04-23
WO1996001847A1 (en) 1996-01-25
DE69528527D1 (en) 2002-11-14
JPH10502807A (en) 1998-03-17
AUPM666894A0 (en) 1994-07-28

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