DE69427100T2 - Production of beta-lactam compounds and intermediates - Google Patents

Production of beta-lactam compounds and intermediates

Info

Publication number
DE69427100T2
DE69427100T2 DE69427100T DE69427100T DE69427100T2 DE 69427100 T2 DE69427100 T2 DE 69427100T2 DE 69427100 T DE69427100 T DE 69427100T DE 69427100 T DE69427100 T DE 69427100T DE 69427100 T2 DE69427100 T2 DE 69427100T2
Authority
DE
Germany
Prior art keywords
beta
optionally substituted
intermediates
production
lactam compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69427100T
Other languages
German (de)
Other versions
DE69427100D1 (en
Inventor
Masaharu Kume
Tadatoshi Kubota
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of DE69427100D1 publication Critical patent/DE69427100D1/en
Publication of DE69427100T2 publication Critical patent/DE69427100T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A process for preparing a beta -lactam compound of the formula (I): <CHEM> which comprises cyclization of an azetidinone derivative of the formula: <CHEM> in which R<1> is hydrogen, alkyl which is optionally substituted, or amino which is optionally substituted; R<2> is a carboxy - protecting group; and X is alkylene which is optionally intervened by -O- or -S-, and/or which is optionally substituted; and R<3> is aryl which is optionally substituted.
DE69427100T 1993-02-10 1994-02-04 Production of beta-lactam compounds and intermediates Expired - Fee Related DE69427100T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2245193 1993-02-10

Publications (2)

Publication Number Publication Date
DE69427100D1 DE69427100D1 (en) 2001-05-23
DE69427100T2 true DE69427100T2 (en) 2001-11-22

Family

ID=12083086

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69427100T Expired - Fee Related DE69427100T2 (en) 1993-02-10 1994-02-04 Production of beta-lactam compounds and intermediates

Country Status (9)

Country Link
US (1) US5580976A (en)
EP (1) EP0611115B1 (en)
KR (1) KR100289512B1 (en)
CN (1) CN1045444C (en)
AT (1) ATE200674T1 (en)
DE (1) DE69427100T2 (en)
ES (1) ES2157952T3 (en)
PT (1) PT611115E (en)
TW (1) TW277059B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009277936B2 (en) * 2008-07-30 2014-11-27 Sun Pharmaceutical Industries Limited Process for the preparation of carbapenem compounds
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
US10695322B2 (en) 2016-01-29 2020-06-30 The Johns Hopkins University Inhibitors of bacterial growth

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4122086A (en) * 1977-07-26 1978-10-24 Smithkline Corporation Isopenicillins
US5317016A (en) * 1991-08-20 1994-05-31 Shionogi Seiyaku Kabushiki Kaisha Pyrrolidylthiocarbapenem derivative

Also Published As

Publication number Publication date
EP0611115A1 (en) 1994-08-17
ATE200674T1 (en) 2001-05-15
KR940019681A (en) 1994-09-14
ES2157952T3 (en) 2001-09-01
CN1045444C (en) 1999-10-06
EP0611115B1 (en) 2001-04-18
PT611115E (en) 2001-07-31
TW277059B (en) 1996-06-01
KR100289512B1 (en) 2001-09-17
DE69427100D1 (en) 2001-05-23
CN1097424A (en) 1995-01-18
US5580976A (en) 1996-12-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee