DE69411747T2 - Phosphinsäure-derivate mit anti-hyperglyzemie und/oder anti-fettsucht wirkung - Google Patents

Phosphinsäure-derivate mit anti-hyperglyzemie und/oder anti-fettsucht wirkung

Info

Publication number
DE69411747T2
DE69411747T2 DE69411747T DE69411747T DE69411747T2 DE 69411747 T2 DE69411747 T2 DE 69411747T2 DE 69411747 T DE69411747 T DE 69411747T DE 69411747 T DE69411747 T DE 69411747T DE 69411747 T2 DE69411747 T2 DE 69411747T2
Authority
DE
Germany
Prior art keywords
hyperglyzemia
fetish
addiction
acid derivatives
phosphinic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69411747T
Other languages
English (en)
Other versions
DE69411747D1 (de
Inventor
Lee Beeley
John Berge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939318744A external-priority patent/GB9318744D0/en
Priority claimed from GB939323981A external-priority patent/GB9323981D0/en
Priority claimed from GB9402341A external-priority patent/GB9402341D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of DE69411747D1 publication Critical patent/DE69411747D1/de
Application granted granted Critical
Publication of DE69411747T2 publication Critical patent/DE69411747T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69411747T 1993-09-09 1994-08-29 Phosphinsäure-derivate mit anti-hyperglyzemie und/oder anti-fettsucht wirkung Expired - Fee Related DE69411747T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB939318744A GB9318744D0 (en) 1993-09-09 1993-09-09 Novel compounds
GB939323981A GB9323981D0 (en) 1993-11-22 1993-11-22 Novel compounds
GB9402341A GB9402341D0 (en) 1994-02-08 1994-02-08 Novel compounds
PCT/EP1994/002886 WO1995007284A1 (en) 1993-09-09 1994-08-29 Phosphinic acid derivatives with anti-hyper glycemic and/or anti-obesity activity

Publications (2)

Publication Number Publication Date
DE69411747D1 DE69411747D1 (de) 1998-08-20
DE69411747T2 true DE69411747T2 (de) 1999-02-04

Family

ID=27266844

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69411747T Expired - Fee Related DE69411747T2 (de) 1993-09-09 1994-08-29 Phosphinsäure-derivate mit anti-hyperglyzemie und/oder anti-fettsucht wirkung

Country Status (5)

Country Link
EP (1) EP0717746B1 (de)
JP (1) JPH09502193A (de)
AU (1) AU7692394A (de)
DE (1) DE69411747T2 (de)
WO (1) WO1995007284A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5491134A (en) * 1994-09-16 1996-02-13 Bristol-Myers Squibb Company Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives
GB201316410D0 (en) * 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8620951D0 (en) * 1986-08-29 1986-10-08 Beecham Group Plc Compounds
DE3630903A1 (de) * 1986-09-11 1988-03-24 Thomae Gmbh Dr K Neue tetrahydronaphthalin- und indanderivate, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
GB9215844D0 (en) * 1992-07-25 1992-09-09 Smithkline Beecham Plc Novel compounds

Also Published As

Publication number Publication date
AU7692394A (en) 1995-03-27
EP0717746A1 (de) 1996-06-26
DE69411747D1 (de) 1998-08-20
JPH09502193A (ja) 1997-03-04
WO1995007284A1 (en) 1995-03-16
EP0717746B1 (de) 1998-07-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee