DE69405292D1 - 6-Piperazinyl-1H-pyrazolo(3,4-b)pyridin-3-carbonsäuren, ihre Ester, Amide und verwandte Verbindungen, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel - Google Patents
6-Piperazinyl-1H-pyrazolo(3,4-b)pyridin-3-carbonsäuren, ihre Ester, Amide und verwandte Verbindungen, ein Verfahren zu ihrer Herstellung und ihre Verwendung als ArzneimittelInfo
- Publication number
- DE69405292D1 DE69405292D1 DE69405292T DE69405292T DE69405292D1 DE 69405292 D1 DE69405292 D1 DE 69405292D1 DE 69405292 T DE69405292 T DE 69405292T DE 69405292 T DE69405292 T DE 69405292T DE 69405292 D1 DE69405292 D1 DE 69405292D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- pyrazolo
- piperazinyl
- medicaments
- amides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- YXZGEDXRAQZPRE-UHFFFAOYSA-N 6-piperazin-1-yl-2h-pyrazolo[3,4-b]pyridine-3-carboxylic acid Chemical class C=1C=C2C(C(=O)O)=NNC2=NC=1N1CCNCC1 YXZGEDXRAQZPRE-UHFFFAOYSA-N 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/071,088 US5300498A (en) | 1993-06-04 | 1993-06-04 | 6-piperazinyl-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acids, esters, amides and related compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69405292D1 true DE69405292D1 (de) | 1997-10-09 |
| DE69405292T2 DE69405292T2 (de) | 1998-02-12 |
Family
ID=22099175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69405292T Expired - Fee Related DE69405292T2 (de) | 1993-06-04 | 1994-05-30 | 6-Piperazinyl-1H-pyrazolo(3,4-b)pyridin-3-carbonsäuren, ihre Ester, Amide und verwandte Verbindungen, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5300498A (de) |
| EP (1) | EP0627432B1 (de) |
| JP (1) | JP2863703B2 (de) |
| AT (1) | ATE157663T1 (de) |
| CA (1) | CA2125103C (de) |
| DE (1) | DE69405292T2 (de) |
| DK (1) | DK0627432T3 (de) |
| ES (1) | ES2107082T3 (de) |
| GR (1) | GR3025154T3 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2797874B1 (fr) * | 1999-08-27 | 2002-03-29 | Adir | Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE60026581T2 (de) * | 1999-12-20 | 2006-12-28 | Eli Lilly And Co., Indianapolis | Indolderivate zur behandlung von depression und angstzuständen |
| US20200288710A1 (en) | 2016-03-15 | 2020-09-17 | Bayer Cropscience Aktiengesellschaft | Substituted sulphonamides for controlling animal pests |
| TW201822637A (zh) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
| MX2020004836A (es) | 2017-11-06 | 2020-10-16 | Rapt Therapeutics Inc | Agentes anticancerígenos. |
| EP3527209A1 (de) * | 2018-02-16 | 2019-08-21 | UCB Biopharma SPRL | Pharmazeutische 6,5-heterobicyclische ringderivate |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1399469A (en) * | 1971-05-25 | 1975-07-02 | Squibb & Sons Inc | Amino derivatives of pyrazolopyridine ketones |
| US3925388A (en) * | 1971-08-05 | 1975-12-09 | Squibb & Sons Inc | 4-Piperazino-{8 3,4-b{9 pyridine-5-carboxylic acids and esters |
| US3840546A (en) * | 1972-11-15 | 1974-10-08 | Squibb & Sons Inc | Amino derivatives of pyrazolopyridine carboxamides |
| CA1071207A (en) * | 1975-04-30 | 1980-02-05 | Theodor Denzel | 4-amino derivatives of 2h-pyrazolo (3,4-b) pyridine-5-carboxylic acids and esters |
| US4020072A (en) * | 1976-05-04 | 1977-04-26 | E. R. Squibb & Sons, Inc. | 5-Aminomethyl-1H-pyrazolo[3,4-b]pyridines |
| US5264576A (en) * | 1992-10-22 | 1993-11-23 | Hoechst-Roussel Pharmaceuticals Incorporated | Pyrazolo[4,3-c]pyridines which are intermediates |
-
1993
- 1993-06-04 US US08/071,088 patent/US5300498A/en not_active Expired - Lifetime
-
1994
- 1994-05-30 DK DK94108282.8T patent/DK0627432T3/da active
- 1994-05-30 ES ES94108282T patent/ES2107082T3/es not_active Expired - Lifetime
- 1994-05-30 AT AT94108282T patent/ATE157663T1/de not_active IP Right Cessation
- 1994-05-30 DE DE69405292T patent/DE69405292T2/de not_active Expired - Fee Related
- 1994-05-30 EP EP94108282A patent/EP0627432B1/de not_active Expired - Lifetime
- 1994-06-03 CA CA002125103A patent/CA2125103C/en not_active Expired - Fee Related
- 1994-06-03 JP JP6121617A patent/JP2863703B2/ja not_active Expired - Fee Related
-
1997
- 1997-10-22 GR GR970402787T patent/GR3025154T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2125103A1 (en) | 1994-12-05 |
| DK0627432T3 (da) | 1998-04-14 |
| CA2125103C (en) | 2001-09-04 |
| US5300498A (en) | 1994-04-05 |
| EP0627432B1 (de) | 1997-09-03 |
| JP2863703B2 (ja) | 1999-03-03 |
| DE69405292T2 (de) | 1998-02-12 |
| GR3025154T3 (en) | 1998-02-27 |
| EP0627432A1 (de) | 1994-12-07 |
| ES2107082T3 (es) | 1997-11-16 |
| JPH06345764A (ja) | 1994-12-20 |
| ATE157663T1 (de) | 1997-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |